Amprolium - CAS 121-25-5
Catalog number: 121-25-5
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Amprolium, a thiamine derivative, could be commonly useful in poultry as a coccidiostat.
Amprolium; Amprolio; Amprolium[ban:inn]; Amprolium [INN-Latin]; Amprolio [INN-Spanish]
10 mM in H2O
-20ºC Freeze
Amprolium could be commonly useful in poultry as a coccidiostat.
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Canonical SMILES:
1.Veterinary drug residues in domestic and imported foods of animal origin in the Republic of Korea.
Kang J1, Park HC, Gedi V, Park SJ, Kim MA, Kim MK, Kwon HJ, Cho BH, Kim TW, Lee KJ, Lim CM. Food Addit Contam Part B Surveill. 2015;8(2):106-12. doi: 10.1080/19393210.2014.1001795. Epub 2015 Feb 19.
The Korean National Residue Programme comprises three different approaches for evaluating domestic and imported foods of animal origin: monitoring, surveillance/enforcement and an exploratory test programme. Monitoring and surveillance/enforcement testing programmes are routinely implemented by 17 Provincial Veterinary Services for domestic products and regional offices of the Animal and Plant Quarantine Agency (QIA) for imported products. The exploratory project conducted at QIA headquarters is designed to test substances that are not included in monitoring and enforcement testing programmes. Here, we carried out exploratory testing for determining the presence of 42 veterinary drugs that have no established Korean maximum residue limits and analysed their levels simultaneously, in a total of 3108 samples of domestic and imported animal-origin foods. Of the tested drugs, acetylsalicylic, paracetamol, clopidol, diclazuril, amprolium, toltrazuril and its metabolites (toltrazuril sulphone and toltrazuril sulphoxide) and phenylbutazone and its metabolites (oxyphenylbutazone) were detected.
2.Determination of fifteen coccidiostats in feed at carry-over levels using liquid chromatography-mass spectrometry.
Pietruk K1, Olejnik M2, Jedziniak P1, Szprengier-Juszkiewicz T1. J Pharm Biomed Anal. 2015 Aug 10;112:50-9. doi: 10.1016/j.jpba.2015.03.019. Epub 2015 Apr 22.
A multi-residue method has been developed and validated for the simultaneous determination of authorized (decoquinate, diclazuril, halofuginone, lasalocid, maduramicin, monensin, narasin, nicarbazin, robenidine, salinomycin and semduramicin) and non-authorized (amprolium, clopidol, ethopabate and toltrazuril) coccidiostats in animal feed. Feed samples were extracted with basic followed by acidified solution in methanol and, after centrifugation, were injected directly into LC-MS/MS system. Detection was performed in selected reaction monitoring mode with both positive and negative electrospray ionization. The time efficient validation experiment has verified the robustness of a method in different types of feed and on two separate LC-MS/MS instruments. The comparison of different quantification methods demonstrated that, against expectations, the standard addition did not prove better in comparison with matrix-matched calibration curve. Although the sample preparation was very easy, the observed matrix effects were not significant for the most part but they could explain the problems with the quantification of some coccidiostats.
3.Five different spectrophotometric methods for determination of Amprolium hydrochloride and Ethopabate binary mixture.
Hussein LA1, Magdy N1, Abbas MM2. Spectrochim Acta A Mol Biomol Spectrosc. 2015 Mar 5;138:395-405. doi: 10.1016/j.saa.2014.11.073. Epub 2014 Nov 29.
Five simple, specific, accurate and precise UV-spectrophotometric methods are adopted for the simultaneous determination of Amprolium hydrochloride (AMP) and Ethopabate (ETH), a binary mixture with overlapping spectra, without preliminary separation. The first method is first derivative of the ratio spectra ((1)DD) for determination of AMP and ETH at 234.7nm and 306.8nm respectively with mean percentage recoveries 99.76±0.907 and 100.29±0.842 respectively. The second method is the mean centering of the ratio spectra for determination of AMP and ETH at 238.8nm and 313nm respectively with mean percentage recoveries 100.26±1.018 and 99.94±1.286 respectively. The third method is based on dual wavelength selection for determination of AMP and ETH at 235.3nm & 308nm and 244nm & 268.4nm respectively with mean percentage recoveries 99.30±1.097 and 100.03±1.065 respectively. The fourth method is ratio difference method for determination of AMP and ETH at 239nm & 310nm and 239nm & 313nm respectively with mean percentage recoveries 99.
4.Thiamine antivitamins - an opportunity of therapy of fungal infections caused by Malassezia pachydermatis and Candida albicans.
Siemieniuk M1,2, Czyzewska U1,2, Strumilo S1, Tylicki A1. Mycoses. 2016 Feb;59(2):108-16. doi: 10.1111/myc.12441. Epub 2015 Dec 22.
Severe skin diseases and systemic fungaemia are caused by Malassezia pachydermatis and Candida albicans respectively. Antifungal therapies are less effective because of chronic character of infections and high percentage of relapses. Therefore, there is a great need to develop new strategies of antifungal therapies. We previously found that oxythiamine decreases proliferation of yeast (Saccharomyces cerevisiae), therefore we suggest that thiamine antivitamins can be considered as antifungal agents. The aim of this study was the comparison of thiamine antivitamins (oxythiamine, amprolium, thiochrome, tetrahydrothiamine and tetrahydrooxythiamine) inhibitory effect on the growth rate and energetic metabolism efficiency in non-pathogenic S. cerevisiae and two potentially pathogenic species M. pachydermatis and C. albicans. Investigated species were cultured on a Sabouraud medium supplemented with trace elements in the presence (40 mg l(-1) ) or absence of each tested antivitamins to estimate their influence on growth rate, enzyme activity and kinetic parameters of pyruvate decarboxylase and malate dehydrogenase of each tested species.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Antiparasitic Products

CAS 31430-15-6 Flubendazole

(CAS: 31430-15-6)

Flubendazole is an anthelmintic agent for MDAY-D2 cells with IC50 of 3 nM. Its brand name is Flutelmium which is a paste manufactured by Janssen Pharmaceutica N...

CAS 321-55-1 Haloxon

(CAS: 321-55-1)

Haloxon is an organophosphorus anthelmintic once used against nematodes of the abomasum and small intestine in ruminants.

CAS 188343-77-3 MBP146-78

(CAS: 188343-77-3)


CAS 134-62-3 N,N-Diethyl-3-methylbenzamide

(CAS: 134-62-3)

N,N-Diethyl-3-methylbenzamide, a benzamide derivative, could be a significant additive in vermifuge.

CAS 69004-03-1 Toltrazuril

(CAS: 69004-03-1)

Toltrazuril is a coccidiostat.

CAS 70288-86-7 Ivermectin

(CAS: 70288-86-7)

Ivermectin is a broad-spectrum antiparasitic medication.

CAS 54965-21-8 Albendazole

(CAS: 54965-21-8)

Albendazole is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations.

CAS 173531-58-3 Naphthoquine phosphate

Naphthoquine phosphate
(CAS: 173531-58-3)

Naphthoquine phosphate and artemisinine are two antimalarials developed in China. Both drugs have proven to be efficacious and well tolerated as monotherapy as ...

CAS 73360-56-2 Niclosamide monohydrate

Niclosamide monohydrate
(CAS: 73360-56-2)

Niclosamide Monohydrate is used for the treatment of most tapeworm infections by inhibiting DNA replication. It inhibits the TNF-induced NF-κB reporter activity...

CAS 3011-89-0 Aklomide

(CAS: 3011-89-0)

Aklomide is antiprotozoal agent against coccidiosis.

CAS 108102-51-8 Fumagillol

(CAS: 108102-51-8)

Fumagillol is a precursor of Fumagillin, which is an antimicrobial agent used for the treatment of microsporidiosis. Fumagillol also exhibits anti-infective and...

CAS 22204-24-6 Pyrantel pamoate

Pyrantel pamoate
(CAS: 22204-24-6)

Pyrantel pamoate is used as a deworming agent in domesticated animals such as horses, hamsters, sheep, pigs, cats, and dogs. It is a combination of pyrantel and...

CAS 23110-15-8 Fumagillin

(CAS: 23110-15-8)

Fumagillin is a compound isolated from the fungus Aspergillus fumigatus. Fumagillin is an antimicrobial agent used in the treatment of microsporidiosis. Fumagil...

CAS 76748-86-2 Pyronaridine Tetraphosphate

Pyronaridine Tetraphosphate
(CAS: 76748-86-2)

Pyronaridine tetraphosphate is an antimalarial agent with an inhibitory effect on P-glycoprotein mediated drug resistance. It inhibits B-hematin formation and E...

CAS 61438-64-0 Closantel Sodium

Closantel Sodium
(CAS: 61438-64-0)

Closantel is a salicylanilide anthelmintic compound; exhibits different anthelmintic spectra and apparent toxicity in mammals.

CAS 1310455-86-7 GNF179 Metabolite

GNF179 Metabolite
(CAS: 1310455-86-7)

GNF179 exhibits a low clearance (CL=22 ml/min/kg, ~25% of hepatic blood flow in mice), a large volume of distribution (steady-state volume of distribution, Vss=...

CAS 318290-98-1 Fluensulfone

(CAS: 318290-98-1)

Fluensulfone is a nematicide of the 1,3-thiazole class. Fluensulfone is used in agriculture for the control of a variety of plant parasitic nematodes.

CAS 97-18-7 Bithionol

(CAS: 97-18-7)

Bithionol is a clinically approved anti-parasitic drug. It has been shown to inhibit solid tumor growth in several preclinical cancer models. It caused dose dep...

CAS 88426-33-9 Buparvaquone

(CAS: 88426-33-9)

Buparvaquone is a hydroxynaphthoquinone antiprotozoal drug related to parvaquone and atovaquone. It is a promising compound for the therapy and prophylaxis of a...

CAS 133413-70-4 PF 1022A

PF 1022A
(CAS: 133413-70-4)

The cyclic depsipeptide PF1022A showed very good anthelmintic activity against Heligmosomoides polygyrus and Heterakis spumosa at 50 mg/kg. In vitro, PF1022A wa...

Chemical Structure

CAS 121-25-5 Amprolium

Quick Inquiry

Verification code

Featured Items