Amprolium - CAS 121-25-5
Catalog number: 121-25-5
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C14H19ClN4
Molecular Weight:
278.78
COA:
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Targets:
Antiparasitic
Description:
Amprolium, a thiamine derivative, could be commonly useful in poultry as a coccidiostat.
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Purity:
98%
Appearance:
Powder
Synonyms:
Amprolium; Amprolio; Amprolium[ban:inn]; Amprolium [INN-Latin]; Amprolio [INN-Spanish]
Solubility:
10 mM in H2O
Storage:
-20ºC Freeze
MSDS:
Inquire
Application:
Amprolium could be commonly useful in poultry as a coccidiostat.
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Grams-Kilos
InChIKey:
LCTXBFGHZLGBNU-UHFFFAOYSA-M
InChI:
InChI=1S/C14H19N4.ClH/c1-3-6-13-16-9-12(14(15)17-13)10-18-8-5-4-7-11(18)2;/h4-5,7-9H,3,6,10H2,1-2H3,(H2,15,16,17);1H/q+1;/p-1
Canonical SMILES:
CCCC1=NC=C(C(=N1)N)C[N+]2=CC=CC=C2C.[Cl-]
1.Veterinary drug residues in domestic and imported foods of animal origin in the Republic of Korea.
Kang J1, Park HC, Gedi V, Park SJ, Kim MA, Kim MK, Kwon HJ, Cho BH, Kim TW, Lee KJ, Lim CM. Food Addit Contam Part B Surveill. 2015;8(2):106-12. doi: 10.1080/19393210.2014.1001795. Epub 2015 Feb 19.
The Korean National Residue Programme comprises three different approaches for evaluating domestic and imported foods of animal origin: monitoring, surveillance/enforcement and an exploratory test programme. Monitoring and surveillance/enforcement testing programmes are routinely implemented by 17 Provincial Veterinary Services for domestic products and regional offices of the Animal and Plant Quarantine Agency (QIA) for imported products. The exploratory project conducted at QIA headquarters is designed to test substances that are not included in monitoring and enforcement testing programmes. Here, we carried out exploratory testing for determining the presence of 42 veterinary drugs that have no established Korean maximum residue limits and analysed their levels simultaneously, in a total of 3108 samples of domestic and imported animal-origin foods. Of the tested drugs, acetylsalicylic, paracetamol, clopidol, diclazuril, amprolium, toltrazuril and its metabolites (toltrazuril sulphone and toltrazuril sulphoxide) and phenylbutazone and its metabolites (oxyphenylbutazone) were detected.
2.Determination of fifteen coccidiostats in feed at carry-over levels using liquid chromatography-mass spectrometry.
Pietruk K1, Olejnik M2, Jedziniak P1, Szprengier-Juszkiewicz T1. J Pharm Biomed Anal. 2015 Aug 10;112:50-9. doi: 10.1016/j.jpba.2015.03.019. Epub 2015 Apr 22.
A multi-residue method has been developed and validated for the simultaneous determination of authorized (decoquinate, diclazuril, halofuginone, lasalocid, maduramicin, monensin, narasin, nicarbazin, robenidine, salinomycin and semduramicin) and non-authorized (amprolium, clopidol, ethopabate and toltrazuril) coccidiostats in animal feed. Feed samples were extracted with basic followed by acidified solution in methanol and, after centrifugation, were injected directly into LC-MS/MS system. Detection was performed in selected reaction monitoring mode with both positive and negative electrospray ionization. The time efficient validation experiment has verified the robustness of a method in different types of feed and on two separate LC-MS/MS instruments. The comparison of different quantification methods demonstrated that, against expectations, the standard addition did not prove better in comparison with matrix-matched calibration curve. Although the sample preparation was very easy, the observed matrix effects were not significant for the most part but they could explain the problems with the quantification of some coccidiostats.
3.Five different spectrophotometric methods for determination of Amprolium hydrochloride and Ethopabate binary mixture.
Hussein LA1, Magdy N1, Abbas MM2. Spectrochim Acta A Mol Biomol Spectrosc. 2015 Mar 5;138:395-405. doi: 10.1016/j.saa.2014.11.073. Epub 2014 Nov 29.
Five simple, specific, accurate and precise UV-spectrophotometric methods are adopted for the simultaneous determination of Amprolium hydrochloride (AMP) and Ethopabate (ETH), a binary mixture with overlapping spectra, without preliminary separation. The first method is first derivative of the ratio spectra ((1)DD) for determination of AMP and ETH at 234.7nm and 306.8nm respectively with mean percentage recoveries 99.76±0.907 and 100.29±0.842 respectively. The second method is the mean centering of the ratio spectra for determination of AMP and ETH at 238.8nm and 313nm respectively with mean percentage recoveries 100.26±1.018 and 99.94±1.286 respectively. The third method is based on dual wavelength selection for determination of AMP and ETH at 235.3nm & 308nm and 244nm & 268.4nm respectively with mean percentage recoveries 99.30±1.097 and 100.03±1.065 respectively. The fourth method is ratio difference method for determination of AMP and ETH at 239nm & 310nm and 239nm & 313nm respectively with mean percentage recoveries 99.
4.Thiamine antivitamins - an opportunity of therapy of fungal infections caused by Malassezia pachydermatis and Candida albicans.
Siemieniuk M1,2, Czyzewska U1,2, Strumilo S1, Tylicki A1. Mycoses. 2016 Feb;59(2):108-16. doi: 10.1111/myc.12441. Epub 2015 Dec 22.
Severe skin diseases and systemic fungaemia are caused by Malassezia pachydermatis and Candida albicans respectively. Antifungal therapies are less effective because of chronic character of infections and high percentage of relapses. Therefore, there is a great need to develop new strategies of antifungal therapies. We previously found that oxythiamine decreases proliferation of yeast (Saccharomyces cerevisiae), therefore we suggest that thiamine antivitamins can be considered as antifungal agents. The aim of this study was the comparison of thiamine antivitamins (oxythiamine, amprolium, thiochrome, tetrahydrothiamine and tetrahydrooxythiamine) inhibitory effect on the growth rate and energetic metabolism efficiency in non-pathogenic S. cerevisiae and two potentially pathogenic species M. pachydermatis and C. albicans. Investigated species were cultured on a Sabouraud medium supplemented with trace elements in the presence (40 mg l(-1) ) or absence of each tested antivitamins to estimate their influence on growth rate, enzyme activity and kinetic parameters of pyruvate decarboxylase and malate dehydrogenase of each tested species.
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CAS 121-25-5 Amprolium

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