Amprolium - CAS 121-25-5
Catalog number: 121-25-5
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Amprolium, a thiamine derivative, could be commonly useful in poultry as a coccidiostat.
Publictions citing BOC Sciences Products
  • >> More
Amprolium; Amprolio; Amprolium[ban:inn]; Amprolium [INN-Latin]; Amprolio [INN-Spanish]
10 mM in H2O
-20ºC Freeze
Amprolium could be commonly useful in poultry as a coccidiostat.
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Canonical SMILES:
1.Veterinary drug residues in domestic and imported foods of animal origin in the Republic of Korea.
Kang J1, Park HC, Gedi V, Park SJ, Kim MA, Kim MK, Kwon HJ, Cho BH, Kim TW, Lee KJ, Lim CM. Food Addit Contam Part B Surveill. 2015;8(2):106-12. doi: 10.1080/19393210.2014.1001795. Epub 2015 Feb 19.
The Korean National Residue Programme comprises three different approaches for evaluating domestic and imported foods of animal origin: monitoring, surveillance/enforcement and an exploratory test programme. Monitoring and surveillance/enforcement testing programmes are routinely implemented by 17 Provincial Veterinary Services for domestic products and regional offices of the Animal and Plant Quarantine Agency (QIA) for imported products. The exploratory project conducted at QIA headquarters is designed to test substances that are not included in monitoring and enforcement testing programmes. Here, we carried out exploratory testing for determining the presence of 42 veterinary drugs that have no established Korean maximum residue limits and analysed their levels simultaneously, in a total of 3108 samples of domestic and imported animal-origin foods. Of the tested drugs, acetylsalicylic, paracetamol, clopidol, diclazuril, amprolium, toltrazuril and its metabolites (toltrazuril sulphone and toltrazuril sulphoxide) and phenylbutazone and its metabolites (oxyphenylbutazone) were detected.
2.Determination of fifteen coccidiostats in feed at carry-over levels using liquid chromatography-mass spectrometry.
Pietruk K1, Olejnik M2, Jedziniak P1, Szprengier-Juszkiewicz T1. J Pharm Biomed Anal. 2015 Aug 10;112:50-9. doi: 10.1016/j.jpba.2015.03.019. Epub 2015 Apr 22.
A multi-residue method has been developed and validated for the simultaneous determination of authorized (decoquinate, diclazuril, halofuginone, lasalocid, maduramicin, monensin, narasin, nicarbazin, robenidine, salinomycin and semduramicin) and non-authorized (amprolium, clopidol, ethopabate and toltrazuril) coccidiostats in animal feed. Feed samples were extracted with basic followed by acidified solution in methanol and, after centrifugation, were injected directly into LC-MS/MS system. Detection was performed in selected reaction monitoring mode with both positive and negative electrospray ionization. The time efficient validation experiment has verified the robustness of a method in different types of feed and on two separate LC-MS/MS instruments. The comparison of different quantification methods demonstrated that, against expectations, the standard addition did not prove better in comparison with matrix-matched calibration curve. Although the sample preparation was very easy, the observed matrix effects were not significant for the most part but they could explain the problems with the quantification of some coccidiostats.
3.Five different spectrophotometric methods for determination of Amprolium hydrochloride and Ethopabate binary mixture.
Hussein LA1, Magdy N1, Abbas MM2. Spectrochim Acta A Mol Biomol Spectrosc. 2015 Mar 5;138:395-405. doi: 10.1016/j.saa.2014.11.073. Epub 2014 Nov 29.
Five simple, specific, accurate and precise UV-spectrophotometric methods are adopted for the simultaneous determination of Amprolium hydrochloride (AMP) and Ethopabate (ETH), a binary mixture with overlapping spectra, without preliminary separation. The first method is first derivative of the ratio spectra ((1)DD) for determination of AMP and ETH at 234.7nm and 306.8nm respectively with mean percentage recoveries 99.76±0.907 and 100.29±0.842 respectively. The second method is the mean centering of the ratio spectra for determination of AMP and ETH at 238.8nm and 313nm respectively with mean percentage recoveries 100.26±1.018 and 99.94±1.286 respectively. The third method is based on dual wavelength selection for determination of AMP and ETH at 235.3nm & 308nm and 244nm & 268.4nm respectively with mean percentage recoveries 99.30±1.097 and 100.03±1.065 respectively. The fourth method is ratio difference method for determination of AMP and ETH at 239nm & 310nm and 239nm & 313nm respectively with mean percentage recoveries 99.
4.Thiamine antivitamins - an opportunity of therapy of fungal infections caused by Malassezia pachydermatis and Candida albicans.
Siemieniuk M1,2, Czyzewska U1,2, Strumilo S1, Tylicki A1. Mycoses. 2016 Feb;59(2):108-16. doi: 10.1111/myc.12441. Epub 2015 Dec 22.
Severe skin diseases and systemic fungaemia are caused by Malassezia pachydermatis and Candida albicans respectively. Antifungal therapies are less effective because of chronic character of infections and high percentage of relapses. Therefore, there is a great need to develop new strategies of antifungal therapies. We previously found that oxythiamine decreases proliferation of yeast (Saccharomyces cerevisiae), therefore we suggest that thiamine antivitamins can be considered as antifungal agents. The aim of this study was the comparison of thiamine antivitamins (oxythiamine, amprolium, thiochrome, tetrahydrothiamine and tetrahydrooxythiamine) inhibitory effect on the growth rate and energetic metabolism efficiency in non-pathogenic S. cerevisiae and two potentially pathogenic species M. pachydermatis and C. albicans. Investigated species were cultured on a Sabouraud medium supplemented with trace elements in the presence (40 mg l(-1) ) or absence of each tested antivitamins to estimate their influence on growth rate, enzyme activity and kinetic parameters of pyruvate decarboxylase and malate dehydrogenase of each tested species.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Antiparasitic Products

CAS 83905-01-5 Azithromycin

(CAS: 83905-01-5)

Azithromycin is an antibiotic for inhibition of parasite growth with IC50 of 8.4 μM.

CAS 20559-55-1 Oxibendazole

(CAS: 20559-55-1)

Oxibendazole is a broad-spectrum anthelmintic

CAS 50357-45-4 Pentamidine

(CAS: 50357-45-4)

Pentamidine is an inhibitor of PRL Phosphatases and also inhibits synthesis of DNA, RNA and protein. It is an antimicrobial medication given for prevention and ...

CAS 58066-85-6 Miltefosine

(CAS: 58066-85-6)

Miltefosine inhibits PI3K/Akt activity with ED50 of 17.2 μM and 8.1 μM in carcinoma cell lines A431 and HeLa, first oral drug for Visceral leishmaniasis, effect...

CAS 137-88-2 Amprolium HCl

Amprolium HCl
(CAS: 137-88-2)

Amprolium chloride is a thiamin antagonist, which prevents carbohydrate synthesis by blocking thiamine uptake.

CAS 123997-26-2 Eprinomectin

(CAS: 123997-26-2)

Eprinomectin(MK-397) is an avermectin selected for development as a topical endectocide; has anthelmintic, insecticidal and miticidal activity.

CAS 1491-41-4 Naftalofos

(CAS: 1491-41-4)

Naftalofos, an isoquinolin derivative, has been found to be an insecticide and commonly used in sheep.

CAS 25514-31-2 Bruceine A

Bruceine A
(CAS: 25514-31-2)

Bruceine A inhibited the in vitro growth of Babesia gibsoni in canine erythrocytes at lower concentration compared with the standard antibabesial drug diminazen...

CAS 33401-94-4 Pyrantel tartrate

Pyrantel tartrate
(CAS: 33401-94-4)

Pyrantel is used to study neuronal nicotinic receptors and has been is used to treat parasiticinfections in livestock. Pyrantel tartrate salt is used to study a...

CAS 101831-37-2 Diclazuril

(CAS: 101831-37-2)

Diclazuril is an anti-coccidial drug.

CAS 102-65-8 Sulfaclozine

(CAS: 102-65-8)

Sulfaclozine, a sulfonamide derivative, is a potent antibacterial and anticoccidial agent which is commonly used as a veterinary drug.

CAS 26155-31-7 Morantel tartrate

Morantel tartrate
(CAS: 26155-31-7)

Morantel tartrate, the 3-methyl thiophene tartrate salt analog of pyrantel tartrate, is a low toxic broad spectrum anthelmintic that is effective against the im...

CAS 71963-77-4 Artemether

(CAS: 71963-77-4)

Artemether is an antimalarial for the treatment of resistant strains of falciparum malaria.

CAS 69004-03-1 Toltrazuril

(CAS: 69004-03-1)

Toltrazuril is a coccidiostat.

CAS 74847-35-1 Pyronaridine

(CAS: 74847-35-1)

Pyronaridine is an antimalarial drug. Pyronaridine was first synthesized in 1970 and has been in clinical use in China since the 1980s. It is one of the compone...

CAS 299-84-3 Fenchlorphos

(CAS: 299-84-3)

Fenchlorphos, with high toxicity it is an organophosphorus pesticide to prevent and cure the parasitic in veterinary medicine.

CAS 5086-74-8 Tetramisole Hydrochloride

Tetramisole Hydrochloride
(CAS: 5086-74-8)

Tetramisole is a mixture of dextro- and levo isomers used as an anthelmintic.

CAS 100-33-4 Pentamidine

(CAS: 100-33-4)

Pentamidine is an antimicrobial agent.

CAS 3011-89-0 Aklomide

(CAS: 3011-89-0)

Aklomide is antiprotozoal agent against coccidiosis.

CAS 1261114-01-5 GNF179

(CAS: 1261114-01-5)

GNF179 exhibits a low clearance (CL=22 ml/min/kg, ~25% of hepatic blood flow in mice), a large volume of distribution (steady-state volume of distribution, Vss=...

Chemical Structure

CAS 121-25-5 Amprolium

Quick Inquiry

Verification code

Featured Items