Ampiroxicam - CAS 99464-64-9
Catalog number: 99464-64-9
Category: Inhibitor
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Molecular Formula:
Molecular Weight:
Ampiroxicam is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug.
CP 65703
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1.Simultaneous determination for oxicam non-steroidal anti-inflammatory drugs in human serum by liquid chromatography-tandem mass spectrometry.
Shirako J;Kawasaki M;Komine K;Kunisue Y;Terada M;Sasaki C;Irie W;Murakami C;Tonooka K;Tomobe K;Shinozuka T Forensic Sci Int. 2013 Apr 10;227(1-3):100-2. doi: 10.1016/j.forsciint.2012.11.016. Epub 2012 Dec 27.
A high-performance liquid chromatography-tandem mass spectrometry (LC/MS/MS) technique was developed for the simultaneous determination of five non-steroidal anti-inflammatory oxicam drugs (ampiroxicam, tenoxicam, piroxicam, meloxicam and lornoxicam) in human plasma. These five oxicam drugs and isoxicam (internal standard) were extracted from human plasma with an Oasis(®) MAX cartridge column and analysed on a Unison UK-C18 column (2.0 mm × 100 mm, 3 μm) with an acetonitrile:10mM formic ammonium buffer (pH 3.0) (50:50) mobile phase at 0.20 ml/min at 37°C. The analytes were detected using a tandem mass spectrometer, equipped with an electrospray ion source (ESI). The instrument was used in multiple-reaction-monitoring (MRM) mode. The extraction yields from a 200 μl human plasma sample (containing 10 ng of each drugs) with the Oasis(®) MAX cartridge column were 93.3-102.5%. The detection limits were 0.01-6.5 ng/ml (S/N=3). Our developed method is very useful for the simultaneous determination of five oxicam (non-steroidal anti-inflammatory) drugs in human plasma by LC/MS/MS.
2.Overview of the mental health research among residents of contaminated territories and Chernobyl clean up workers/"liquidators" in Belarus.
Igumnov SA;Lapanau PS Probl Radiac Med Radiobiol. 2015 Dec;20:55-74.
in ;English;, ;Russian;V obzore predstavlena posledniaia informatsiia, kasaiushchaiasia issledovaniia vliianiia avarii na Chernobyl'skoi AÉS na psikhicheskoe zdorov'e razlichnykh grupp naseleniia Belarusi. Rassmotren patogenez psikhicheskikh rasstroistv, razvivaiushchikhsia u lits, prozhivaiushchikh na zagriaznennykh territoriiakh. Proanalizirovany razlich nye faktory, vliiaiushchie na psikhicheskoe zdorov'e takikh grupp naseleniia, kak „likvidatory ". Raskryto iavle nie „samoselov " – liudei, kotorye dobrovol'no vernulis' v svoi doma v zone otchuzhdeniia posle nasil'stven nogo pereseleniia. Issledovany dannye, v tom chisle sobstvennye, kasaiushchiesia psikhicheskikh rasstroistv u de tei, podvergshikhsia vozdeistviiu radioaktivnogo oblucheniia v raznye periody razvitiia.;This review deals with the latest information concerning the studies of the effect of the Chernobyl accident on the mental health of different population groups of Belarus. Observed the pathogenesis of mental disorders, develop ing in individuals living in the contaminated territories. Reviewed different factors affecting the mental health of such population group as the liquidators. Disclosed is a phenomenon of squatters ("samosely") - people who vol untarily returned to their homes in the exclusion zone after the forced relocation.
3.Inhibition of myeloid cell leukemia-1 by tolfenamic acid induces apoptosis in mucoepidermoid carcinoma.
Choi KH;Shim JH;Huong LD;Cho NP;Cho SD Oral Dis. 2011 Jul;17(5):469-75. doi: 10.1111/j.1601-0825.2010.01774.x. Epub 2010 Dec 23.
OBJECTIVES: ;The aim of this study was to evaluate the role of tolfenamic acid (Tol) and ampiroxicam (Amp) in the apoptotic regulation of YD-15 salivary mucoepidermoid carcinoma (MEC).;MATERIALS AND METHODS: ;The effect of Tol on apoptosis and its mechanism were examined using a 3-(4,5-dimethylthiazol-2-yl)-5-(2,4-disulfophenyl)-2-(4-sulfophenyl)-2H-tetrazolium assay, Sub-G(1) population, Western blot analysis, 4'-6-Diamidino-2-phenylindole staining, reverse transcriptase polymerase chain reaction, immunostaining and small interfering RNA transfection.;RESULTS: ;Tol inhibited cell growth of YD-15 cells but Amp did not. Tol induces apoptosis in YD-15 cells as evidenced by nuclear fragmentation, accumulation of the sub-G1 phase and the activation of caspase 3. Tol inhibited myeloid cell leukemia-1 (MCL-1) at the protein and mRNA levels. The treatment of MCL-1 siRNA to YD-15 cells resulted in the activation of caspase 3 and the inhibition of cell growth. Moreover, MCL-1 was regulated by specificity protein 1, but not by mitogen-activated protein kinases.;CONCLUSION: ;These results suggest that Tol could be a potent anti-cancer drug for YD-15 MEC cells that acts by regulating the MCL-1 protein.
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CAS 99464-64-9 Ampiroxicam

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