Ampicillin sodium - CAS 69-52-3
Catalog number: 69-52-3
Category: Inhibitor
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Ampicillin is a beta-lactam antibiotic that is part of the aminopenicillin family.
Benzylpenicillin Sodium
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1.Mutations decreasing intrinsic β-lactam resistance are linked to cell division in the nosocomial pathogen Acinetobacter baumannii.
Knight D1, Dimitrova DD2, Rudin SD3, Bonomo RA3, Rather PN4. Antimicrob Agents Chemother. 2016 Apr 11. pii: AAC.00361-16. [Epub ahead of print]
Transposon mutagenesis was used to identify novel determinants of intrinsic β-lactam resistance inAcinetobacter baumannii An EZ-Tn5 transposon insertion in a gene corresponding to A1S_0225, resulted in a 4-fold decrease in resistance to ampicillin, cefotaxime, imipenem and ceftriaxone, but did not alter resistance to other classes of antibiotics. Based on this phenotype, the gene was designatedblsA(β-lactamsusceptibility). TheblsA::EZ-Tn5 mutation conferred a similar phenotype inA. baumanniistrain ATCC17978. The wild-typeblsAgene complemented theblsA::EZTn-5 insertion and restored β-lactam resistance levels back to wild-type. TheblsAmutation also increased β-lactam susceptibility in anadeB/adeJdouble mutant, indicating that theblsAmutation acted independently of these efflux systems to mediate susceptibility. In addition, mRNA levels for theblaOXAorblaADCβ-lactamase genes were not altered by theblsAmutation. TheblsAmutation resulted in a prominent cell division and morphological defect, with cells exhibiting a highly elongated phenotype, combined with large bulges in some cells.
2.Frequency, Antimicrobial Resistance and Genetic Diversity of Klebsiella pneumoniae in Food Samples.
Guo Y1, Zhou H2,3, Qin L1, Pang Z1, Qin T2,3, Ren H2, Pan Z1, Zhou J1. PLoS One. 2016 Apr 14;11(4):e0153561. doi: 10.1371/journal.pone.0153561. eCollection 2016.
This study aimed to assess the frequency of Klebsiella pneumoniae in food samples and to detect antibiotic resistance phenotypes, antimicrobial resistance genes and the molecular subtypes of the recovered isolates. A total of 998 food samples were collected, and 99 (9.9%) K. pneumoniae strains were isolated; the frequencies were 8.2% (4/49) in fresh raw seafood, 13.8% (26/188) in fresh raw chicken, 11.4% (34/297) in frozen raw food and 7.5% (35/464) in cooked food samples. Antimicrobial resistance was observed against 16 antimicrobials. The highest resistance rate was observed for ampicillin (92.3%), followed by tetracycline (31.3%), trimethoprim-sulfamethoxazole (18.2%), and chloramphenicol (10.1%). Two K. pneumoniae strains were identified as extended-spectrum β-lactamase (ESBL)-one strain had three beta-lactamases genes (blaSHV, blaCTX-M-1, and blaCTX-M-10) and one had only the blaSHV gene. Nineteen multidrug-resistant (MDR) strains were detected; the percentage of MDR strains in fresh raw chicken samples was significantly higher than in other sample types (P<0.
3.Comparison of Clinical Laboratory Standards Institute and European Committee on Antimicrobial Susceptibility Testing guidelines for the interpretation of antibiotic susceptibility at a University teaching hospital in Nairobi, Kenya: a cross-sectional stud
Kassim A1, Omuse G2, Premji Z2, Revathi G2. Ann Clin Microbiol Antimicrob. 2016 Apr 11;15(1):21. doi: 10.1186/s12941-016-0135-3.
BACKGROUND: The Clinical Laboratory Standards Institute (CLSI) and the European Committee on Antimicrobial Susceptibility Testing (EUCAST) guidelines are the most popular breakpoint guidelines used in antimicrobial susceptibility testing worldwide. The EUCAST guidelines are freely available to users while CLSI is available for non-members as a package of three documents for US $500 annually. This is prohibitive for clinical microbiology laboratories in resource poor settings. We set out to compare antibiotic susceptibility determined by the two guidelines to determine whether adoption of EUCAST guidelines would significantly affect our susceptibility patterns.
4.A redesigned CRISPR/Cas9 system for marker-free genome editing in Plasmodium falciparum.
Lu J1, Tong Y2, Pan J2, Yang Y1, Liu Q1, Tan X1, Zhao S1, Qin L3, Chen X4. Parasit Vectors. 2016 Apr 11;9(1):198. doi: 10.1186/s13071-016-1487-4.
BACKGROUND: A highly efficient CRISPR/Cas9-based marker-free genome editing system has been established in Plasmodium falciparum (Pf). However, with the current methods, two drug-selectable markers are needed for episome retention, which may present hurdles for consecutive genome manipulations due to the limited number of available selectable markers. The loading capacity of donor DNA is also unsatisfactory due to the large size of the Cas9 nuclease and sgRNA co-expression system, which limits the size of knock-in DNA fragments. Because of the inefficient end joining (EJ) DNA repair mechanism of Pf, a suicide-rescue approach could be used to address the challenges. Cas9 nuclease and sgRNA were co-expressed from a single plasmid (suicide vector) with one selectable marker, and the donor DNA was ligated into the other plasmid (rescue vector) containing only the ampicillin-resistance gene (AmpR) and a ColEl replication origin (ori). Nonetheless, whether this approach can mediate even the regular gene editing in Pf remains unknown.
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CAS 69-52-3 Ampicillin sodium

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