Amphotericin B - CAS 1397-89-3
Catalog number: 1397-89-3
Category: Inhibitor
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Molecular Formula:
C47H73NO17
Molecular Weight:
924.08
COA:
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Targets:
Antifungal
Description:
Amphotericin B is a polyene, antifungal antibiotic produced from a strain of Streptomyces nodosus. (IC50=0.028–0.290 μg/ml)
Purity:
>98%
Synonyms:
NSC 527017; NSC527017; NSC-527017
MSDS:
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InChIKey:
APKFDSVGJQXUKY-KKGHZKTASA-N
InChI:
InChI=1S/C47H73NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56/h5-18,27-38,40-44,46,49-54,56-58,61H,19-26,48H2,1-4H3,(H,59,60)/t27-,28-,29-,30+,31+,32+,33-,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1
Canonical SMILES:
CC1C=CC=CC=CC=CC=CC=CC=CC(CC2C(C(CC(O2)(CC(CC(C(CCC(CC(CC(=O)OC(C(C1O)C)C)O)O)O)O)O)O)O)C(=O)O)OC3C(C(C(C(O3)C)O)N)O
1.Comparison of the antifungal activity of micafungin and amphotericin B against Candida tropicalis biofilms.
Marcos-Zambrano LJ1, Escribano P2, Bouza E3, Guinea J4. J Antimicrob Chemother. 2016 May 4. pii: dkw162. [Epub ahead of print]
OBJECTIVES: Candida tropicalis is the fourth most common cause of candidaemia in hospitalized patients and associated mortality is high. C. tropicalis frequently causes biofilm-related infections. Echinocandins and amphotericin B show potent in vitro activity against C. albicans biofilms, but their activity against C. tropicalis biofilms has received little attention.
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CAS 1397-89-3 Amphotericin B

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