Amoxicillin Sodium - CAS 34642-77-8
Catalog number: 34642-77-8
Category: Inhibitor
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Molecular Formula:
C16H18N3O5S.Na
Molecular Weight:
387.39
COA:
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Targets:
Antibacterial
Description:
Amoxicillin Sodium is a moderate- spectrum, bacteriolytic, β-lactam antibiotic.
Purity:
>98%
Synonyms:
Clavulanate
MSDS:
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InChIKey:
BYHDFCISJXIVBV-UHFFFAOYSA-M
InChI:
InChI=1S/C16H19N3O5S.Na/c1-16(2)11(15(23)24)19-13(22)10(14(19)25-16)18-12(21)9(17)7-3-5-8(20)6-4-7;/h3-6,9-11,14,20H,17H2,1-2H3,(H,18,21)(H,23,24);/q;+1/p-1
Canonical SMILES:
CC1(C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=C(C=C3)O)N)C(=O)[O-])C.[Na+]
1.The effects of amoxicillin, ceftiofur, doxycycline, tiamulin and tulathromycin on swine humoral immune response induced by erysipelas vaccination.
Pomorska-Mól M1, Kwit K1, Wierzchosławski K2, Dors A1, Pejsak Z1. Vet Rec. 2016 Apr 12. pii: vetrec-2015-103533. doi: 10.1136/vr.103533. [Epub ahead of print]
It addition to their antimicrobial properties, antibiotics can influence the host immune system (modulation of cytokine secretion, antibody production and T-cell proliferation). In the present study, the authors studied the effects of therapeutic doses of amoxicillin (AMX), ceftiofur (CEF), doxycycline (DOXY), tiamulin (TIAM) and tulathromycin (TUL) on the postvaccinal immune response after pigs had been vaccinated against erysipelas. Because humoral immunity is considered as the most important in the protection against swine erysipelas, the present study focused on the interactions between antibiotics and postvaccinal humoral immunity. One hundred and five, eight-week-old pigs of both sexes were used. Specific antibodies to theErysipelothrix rhusiopathiaeantigen were determined using a commercial ELISA test. In pigs treated with DOXY or CEF or TIAM, a significant reduction in the number of positive pigs was observed four and six weeks after the second dose of vaccine, compared with the remaining vaccinated groups.
2.Convergence palsy secondary to amoxicillin.
Pérez-Roca F1, Alfaro Juárez A2, Sánchez Merino C2, Navarro Mingorance A3. Arch Soc Esp Oftalmol. 2016 Apr 7. pii: S0365-6691(16)00130-1. doi: 10.1016/j.oftal.2016.02.024. [Epub ahead of print]
CASE REPORT: We present the case of an 11-year-old boy with acute diplopia in near vision secondary to transient convergence palsy, possibly in relation to amoxicillin.
3.Quantifying Attachment and Antibiotic Resistance of from Conventional and Organic Swine Manure.
Zwonitzer MR, Soupir ML, Jarboe LR, Smith DR. J Environ Qual. 2016 Mar;45(2):609-17. doi: 10.2134/jeq2015.05.0245.
Broad-spectrum antibiotics are often administered to swine, contributing to the occurrence of antibiotic-resistant bacteria in their manure. During land application, the bacteria in swine manure preferentially attach to particles in the soil, affecting their transport in overland flow. However, a quantitative understanding of these attachment mechanisms is lacking, and their relationship to antibiotic resistance is unknown. The objective of this study is to examine the relationships between antibiotic resistance and attachment to very fine silica sand in collected from swine manure. A total of 556 isolates were collected from six farms, two organic and four conventional (antibiotics fed prophylactically). Antibiotic resistance was quantified using 13 antibiotics at three minimum inhibitory concentrations: resistant, intermediate, and susceptible. Of the 556 isolates used in the antibiotic resistance assays, 491 were subjected to an attachment assay.
4.Helicobacter pylori therapy: a paradigm shift.
Graham DY1, Dore MP1,2. Expert Rev Anti Infect Ther. 2016 Apr 14. [Epub ahead of print]
Helicobacter pylori (H. Pylori) is a leading cause of gastroduodenal disease, including gastric cancer. H. pylori eradication therapies and their efficacy are summarized. A number of current treatment regimens will reliably yield >90% or 95% cure rates with susceptible strains. None has proven to be superior. We show how to predict the efficacy of a regimen in any population provided one knows the prevalence of antibiotic resistance. As with other infectious diseases, therapy should always be susceptibility-based. Susceptibility testing should be demanded. We provide recommendations for empiric therapies when the only option and describe how to distinguish studies providing misinformation from those providing reliable and interpretable data. When treated as an infectious disease, high H. pylori cure rates are relatively simple to reliably achieve.
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CAS 34642-77-8 Amoxicillin Sodium

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