Amorolfine HCl - CAS 78613-38-4
Catalog number: 78613-38-4
Category: Inhibitor
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Molecular Formula:
C21H36ClNO
Molecular Weight:
353.97
COA:
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Targets:
Antifungal
Description:
Amorolfine HCl is an antifungal reagent.
Purity:
>98%
Synonyms:
KWD 2019
MSDS:
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InChIKey:
XZKWIPVTHGWDCF-KUZYQSSXSA-N
InChI:
InChI=1S/C21H35NO.ClH/c1-7-21(5,6)20-10-8-19(9-11-20)12-16(2)13-22-14-17(3)23-18(4)15-22;/h8-11,16-18H,7,12-15H2,1-6H3;1H/t16?,17-,18+;
Canonical SMILES:
CCC(C)(C)C1=CC=C(C=C1)CC(C)CN2CC(OC(C2)C)C.Cl
1.In vitro studies with R 51,211 (itraconazole).
Espinel-Ingroff A, Shadomy S, Gebhart RJ. Antimicrob Agents Chemother. 1984 Jul;26(1):5-9.
The in vitro activity of R 51,211 (itraconazole, accepted generic name; Janssen Pharmaceutica, Beerse, Belgium), a new orally active triazole, was compared with those of two existing orally active azoles, ketoconazole and BAY n 7133, and a topical agent, Ro 14-4767/002. An agar dilution procedure (Kimmig agar) was performed with 148 isolates of pathogenic fungi. Incubation was at 30 degrees C from 48 h to 7 days. R 51,211 was dissolved in 0.2 N HCl in absolute ethanol, ketoconazole was dissolved in 0.2 N HCl alone, BAY n 7133 was dissolved in absolute ethanol, and Ro 14-4767/002 was dissolved in dimethyl sulfoxide. R 51,211 and Ro 14-4767/002 were the most active drugs against isolates of Histoplasma capsulatum, and R 51,211 showed the greatest activity in vitro against isolates of Blastomyces dermatitidis and Cryptococcus neoformans. Ro 14-4767/002 was the most active drug against 30 isolates of dermatophytes, followed by R 51,211, ketoconazole, and BAY n 7133.
2.Application of Hansen Solubility Parameters to predict drug-nail interactions, which can assist the design of nail medicines.
Hossin B1, Rizi K1, Murdan S2. Eur J Pharm Biopharm. 2016 May;102:32-40. doi: 10.1016/j.ejpb.2016.02.009. Epub 2016 Feb 23.
We hypothesised that Hansen Solubility Parameters (HSPs) can be used to predict drug-nail affinities. Our aims were to: (i) determine the HSPs (δD, δP, δH) of the nail plate, the hoof membrane (a model for the nail plate), and of the drugs terbinafine HCl, amorolfine HCl, ciclopirox olamine and efinaconazole, by measuring their swelling/solubility in organic liquids, (ii) predict nail-drug interactions by comparing drug and nail HSPs, and (iii) evaluate the accuracy of these predictions using literature reports of experimentally-determined affinities of these drugs for keratin, the main constituent of the nail plate and hoof. Many solvents caused no change in the mass of nail plates, a few solvents deswelled the nail, while others swelled the nail to varying extents. Fingernail and toenail HSPs were almost the same, while hoof HSPs were similar, except for a slightly lower δP. High nail-terbinafine HCl, nail-amorolfine HCl and nail-ciclopirox olamine affinities, and low nail-efinaconazole affinities were then predicted, and found to accurately match experimental reports of these drugs' affinities to keratin.
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CAS 78613-38-4 Amorolfine HCl

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