Catalog number: 86-42-0
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
Molecular Weight:
Amodiaquine is a drug which used to treat malaria, including Plasmodium falciparum malaria when uncomplicated. It has similar action to chloroquine. It is not available in the United States, but widely available in Africa.
Off-White to Pale Yellow Solid
4-[(7-Chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]phenol; 4-[(7-Chloro-4-quinolyl)amino]-α-(diethylamino)-o-cresol; Camochin; Camoquin; Camoquinal; Camoquine; Flavoquine; Miaquin; NSC 13453; SN-10751;
DMSO (Slightly), Methanol (Slightly)
-20℃ Freezer
An antimalarial.
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Boiling Point:
No Data Available
Melting Point:
>197℃ (dec.)
Canonical SMILES:
Current Developer:
1.Subsidising artemisinin-based combination therapy in the private retail sector.
Opiyo N1, Yamey G, Garner P. Cochrane Database Syst Rev. 2016 Mar 9;3:CD009926. doi: 10.1002/14651858.CD009926.pub2.
BACKGROUND: Malaria causes ill health and death in Africa. Treating illness promptly with artemisinin-based combination therapy (ACT) is likely to cure people and avoid the disease progressing to more severe forms and death. In many countries, ACT use remains low. Part of the problem is that most people seek treatment from the retail sector where ACTs are expensive; this expense is a barrier to their use.The Global Fund and other international organisations are subsidising the cost of ACTs for private retail providers to improve access to ACTs. The subsidy was initially organised through a stand-alone initiative, called the Affordable Medicines Facility-malaria (AMFm), but has since been integrated into the Global Fund core grant management and financial processes.
2.Characterization of drug authenticity using thin-layer chromatography imaging with a mobile phone.
Yu H1, Le HM2, Kaale E3, Long KD4, Layloff T5, Lumetta SS2, Cunningham BT6. J Pharm Biomed Anal. 2016 Mar 9;125:85-93. doi: 10.1016/j.jpba.2016.03.018. [Epub ahead of print]
Thin-layer chromatography (TLC) has a myriad of separation applications in chemistry, biology, and pharmacology due to its simplicity and low cost. While benchtop laboratory sample application and detection systems for TLC provide accurate quantitation of TLC spot positions and densities, there are many applications where inexpensive and portable instruments would greatly expand the applicability of the technology. In this work, we demonstrate identity verification and concentration determination of pharmaceutical compounds via TLC using a custom 3D-printed cradle that interfaces with an ordinary mobile phone. The cradle holds the mobile phone's internal, rear-facing camera in a fixed position relative to a UV lamp and a TLC plate that includes a phosphor in the stationary phase. Analysis of photographs thus reveals the locations and intensities of principal spots of UV--absorbing drugs. Automated image analysis software determines the center location and density of dark spots, which, using integrated calibration spots of known drug compounds and concentrations, can be used to determine if a drug has been diluted or substituted.
3.Quality Assessment of Artemether-Lumefantrine Samples and Artemether Injections Sold in the Cape Coast Metropolis.
Prah J1, Ameyaw EO2, Afoakwah R2, Fiawoyife P3, Oppong-Danquah E3, Boampong JN2. J Trop Med. 2016;2016:8602619. doi: 10.1155/2016/8602619. Epub 2016 Feb 23.
Most prescribers and patients in Ghana now opt for the relatively expensive artemether/lumefantrine rather than artesunate-amodiaquine due to undesirable side effects in the treatment of uncomplicated malaria. The study sought to determine the existence of substandard and/or counterfeit artemether-lumefantrine tablets and suspension as well as artemether injection on the market in Cape Coast. Six brands of artemether-lumefantrine tablets, two brands of artemether-lumefantrine suspensions, and two brands of artemether injections were purchased from pharmacies in Cape Coast for the study. The mechanical properties of the tablets were evaluated. The samples were then analyzed for the content of active ingredients using High Performance Liquid Chromatography with a variable wavelength detector. None of the samples was found to be counterfeit. However, the artemether content of the samples was variable (93.22%-104.70% of stated content by manufacturer).
4.Four Artemisinin-Based Treatments in African Pregnant Women with Malaria.
PREGACT Study Group, Pekyi D, Ampromfi AA, Tinto H, Traoré-Coulibaly M, Tahita MC, Valéa I, Mwapasa V, Kalilani-Phiri L, Kalanda G, Madanitsa M, Ravinetto R, Mutabingwa T, Gbekor P, Tagbor H, Antwi G, Menten J, De Crop M, Claeys Y, Schurmans C, Van Overmeir C, Thriemer K, Van Geertruyden JP, D'Alessandro U, Nambozi M, Mulenga M, Hachizovu S, Kabuya JB, Mulenga J. N Engl J Med. 2016 Mar 10;374(10):913-27. doi: 10.1056/NEJMoa1508606.
BACKGROUND: Information regarding the safety and efficacy of artemisinin combination treatments for malaria in pregnant women is limited, particularly among women who live in sub-Saharan Africa.
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