Category: Inhibitor
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Potassium Channel
AmmTX3 is a peptide that can be isolated from the venom of Androctonus mauretanicus and belongs scorpion toxin of the α-KTX15 subfamily. It is a specific potassium 4 (Kv4) channel blocker and could reduce the A-type potassium current in mouse cerebellar granule neurons through this channel. It has specific high-affinity blockade for Kv4.2 and Kv4.3 channels of mice because of expression of dipeptidyl peptidase-like proteins (DPP) DPP6 and DPP10. It also has a small blocking effect on hERG channels without alteration of the gating kinetics.
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