|Description||Amlodipine maleate is a long-acting dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker). It inhibits the movement of calcium ions into vascular smooth muscle cells and cardiac muscle cells. It is a peripheral arterial vasodilator that acts directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and reduction in blood pressure. It binds to both dihydropyridine and nondihydropyridine binding sites. It inhibits calcium ion influx across cell membranes selectively, with a greater effect on vascular smooth muscle cells than on cardiac muscle cells. It has a prolonged half-life due to its high efficiency.|
|Appearance||White to pale yellow crystalline powder|
|Synonyms||2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester (Z)-2-butenedioate;3-ethyl 5-Methyl 2-((2-aMinoethoxy)Methyl)-4-(2-chlorophenyl)-6-Methyl-1,4-dihydropyridine-3,5-dicarboxylate Maleate;3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate|
|Solubility||32mg/ml in DMSO|
|Application||Amlodipine maleate is a peripheral arterial vasodilator that acts directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and reduction in blood pressure.|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
|Quantity||Kilogram to ton|
|Boiling Point||527.2ºC at 760 mmHg|
|Melting Point||174.23 °C|
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