Amlodipine maleate - CAS 88150-47-4
Catalog number:
88150-47-4
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C24H29ClN2O9
Molecular Weight:
524.95
COA:
Inquire
Targets:
Calcium Channel
Description:
Amlodipine maleate is a long-acting dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker). It inhibits the movement of calcium ions into vascular smooth muscle cells and cardiac muscle cells. It is a peripheral arterial vasodilator that acts directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and reduction in blood pressure. It binds to both dihydropyridine and nondihydropyridine binding sites. It inhibits calcium ion influx across cell membranes selectively, with a greater effect on vascular smooth muscle cells than on cardiac muscle cells. It has a prolonged half-life due to its high efficiency.
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Purity:
98%
Appearance:
White to pale yellow crystalline powder
Synonyms:
2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester (Z)-2-butenedioate;3-ethyl 5-Methyl 2-((2-aMinoethoxy)Methyl)-4-(2-chlorophenyl)-6-Methyl-1,4-dihydropyridine-3,5-dicarboxylate Maleate;3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
Solubility:
32mg/ml in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
Amlodipine maleate is a peripheral arterial vasodilator that acts directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and reduction in blood pressure.
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Kilogram to ton
Boiling Point:
527.2ºC at 760 mmHg
Melting Point:
174.23 °C
InChIKey:
TZNOWAJJWCGILX-BTJKTKAUSA-N
InChI:
InChI=1S/C20H25ClN2O5.C4H4O4/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21;5-3(6)1-2-4(7)8/h5-8,17,23H,4,9-11,22H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
Canonical SMILES:
CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN.C(=CC(=O)O)C(=O)O
1.Diuretics for Hypertension: A Review and Update.
Roush GC1, Sica DA2. Am J Hypertens. 2016 Apr 5. pii: hpw030. [Epub ahead of print]
This review and update focuses on the clinical features of hydrochlorothiazide (HCTZ), the thiazide-like agents chlorthalidone (CTDN) and indapamide (INDAP), potassium-sparing ENaC inhibitors and aldosterone receptor antagonists, and loop diuretics. Diuretics are the second most commonly prescribed class of antihypertensive medication, and thiazide-related diuretics have increased at a rate greater than that of antihypertensive medications as a whole. The latest hypertension guidelines have underscored the importance of diuretics for all patients, but particularly for those with salt-sensitive and resistant hypertension. HCTZ is 4.2-6.2 systolic mm Hg less potent than CTDN, angiotensin-converting enzyme inhibitors, beta blockers, and calcium channel blockers by 24-hour measurements and 5.1mm Hg systolic less potent than INDAP by office measurements. For reducing cardiovascular events (CVEs), HCTZ is less effective than enalapril and amlodipine in randomized trials, and, in network analysis of trials, it is less effective than CTDN and HCTZ-amiloride.
2.Starting the polypill: the use of a single age cut-off in males and females.
Wald NJ1, Luteijn JM2, Morris JK2. J Med Screen. 2016 Apr 11. pii: 0969141316631578. [Epub ahead of print]
OBJECTIVE: Age screening and preventive medication for future myocardial infarction and stroke has been previously described. We aimed to ascertain whether different age cut-offs are needed for males and females.
3.Effect of amlodipine on mouse renal interstitial fibrosis.
Honma S1, Nakamura K2, Shinohara M2, Mitazaki S2, Abe S2, Yoshida M2. Eur J Pharmacol. 2016 Mar 28. pii: S0014-2999(16)30171-6. doi: 10.1016/j.ejphar.2016.03.041. [Epub ahead of print]
Unilateral ureteral obstruction (UUO) is a well-established method to study interstitial fibrosis of the kidney. In this study, we investigated the effects of a calcium channel blocker, amlodipine, on UUO-induced renal interstitial fibrosis in mice. UUO significantly increased the fibrotic area in the obstructed kidney, but this change was inhibited by amlodipine (6.7mg/kg/day in drinking water). mRNA expression of heat shock protein (HSP) 47 and type IV collagen was increased in the kidneys of UUO mice. Amlodipine reduced the expression of both HSP47 and type IV collagen mRNAs. Phosphorylation of c-jun-N-terminal kinase (JNK) was significantly increased by UUO, but the change was inhibited by amlodipine. Collectively, these results suggest that amlodipine may inhibit the expression of HSP47 and type IV collagen by reducing phosphorylation of JNK and ameliorating the renal interstitial fibrosis induced by UUO.
4.Review of Top 10 Prescribed Drugs and Their Interaction with Dental Treatment.
Weinstock RJ1, Johnson MP2. Dent Clin North Am. 2016 Apr;60(2):421-34. doi: 10.1016/j.cden.2015.11.005.
The proportion of people over age 60 is growing faster than any other group. Many patients take several medications to manage multiple chronic medical conditions. Poor oral health is common and dental visits by patients over the age of 65 are increasing. The dentist must recognize that these medications may interact with dental treatment. This article reviews the top 10 prescribed drugs as listed in the IMS Institute national prescription audit in January 2015 and reviews the interactions between these medications and dental treatment. The medications reviewed include levothyroxine, acetaminophen/hydrocodone, lisinopril, metoprolol, atorvastatin, amlodipine, metformin, omeprazole, simvastatin, and albuterol.
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CAS 88150-47-4 Amlodipine maleate

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