Amlodipine Besylate - CAS 111470-99-6
Catalog number: 111470-99-6
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C20H25ClN2O5.C6H6O3S
Molecular Weight:
567.05
COA:
Inquire
Targets:
Calcium Channel
Description:
Amlodipine Besylate is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain.
Purity:
>98%
Synonyms:
N/A
MSDS:
Inquire
InChIKey:
ZPBWCRDSRKPIDG-UHFFFAOYSA-N
InChI:
InChI=1S/C20H25ClN2O5.C6H6O3S/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21;7-10(8,9)6-4-2-1-3-5-6/h5-8,17,23H,4,9-11,22H2,1-3H3;1-5H,(H,7,8,9)
Canonical SMILES:
CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN.C1=CC=C(C=C1)S(=O)(=O)O
1.Unexpected Effect of Calcium Channel Blockers on the Optic Nerve Compartment Syndrome.
Konieczka K1, Todorova MG1, Bojinova RI2, Binggeli T1, Chackathayil TN1, Flammer J1. Klin Monbl Augenheilkd. 2016 Apr;233(4):387-390. Epub 2016 Apr 26.
Background: The optic nerve compartment syndrome is a pathological condition in which cerebrospinal fluid of the subarachnoid space surrounding the optic nerve is partly or totally segregated from the cerebrospinal fluid of the intracranial subarachnoid space, leading - inter alia - to an increase in the diameter of the optic nerve sheath. The pathogenesis of this condition remains unclear. We have observed clinically that optic nerve compartment syndrome often occurs in normal tension glaucoma patients with Flammer syndrome. To treat Flammer syndrome, some glaucoma patients received a low dose of a calcium channel blocker and we analysed whether this treatment also had an effect on the optic nerve compartment syndrome. Patients and Methods: We retrospectively analysed the data of 10 eyes of seven patients suffering from a combination of primary open angle glaucoma, optic nerve compartment syndrome, and Flammer syndrome. We included subjects who had eye socket echography before and after a few months of therapy with a calcium channel blocker.
2.Diuretics for Hypertension: A Review and Update.
Roush GC1, Sica DA2. Am J Hypertens. 2016 Apr 5. pii: hpw030. [Epub ahead of print]
This review and update focuses on the clinical features of hydrochlorothiazide (HCTZ), the thiazide-like agents chlorthalidone (CTDN) and indapamide (INDAP), potassium-sparing ENaC inhibitors and aldosterone receptor antagonists, and loop diuretics. Diuretics are the second most commonly prescribed class of antihypertensive medication, and thiazide-related diuretics have increased at a rate greater than that of antihypertensive medications as a whole. The latest hypertension guidelines have underscored the importance of diuretics for all patients, but particularly for those with salt-sensitive and resistant hypertension. HCTZ is 4.2-6.2 systolic mm Hg less potent than CTDN, angiotensin-converting enzyme inhibitors, beta blockers, and calcium channel blockers by 24-hour measurements and 5.1mm Hg systolic less potent than INDAP by office measurements. For reducing cardiovascular events (CVEs), HCTZ is less effective than enalapril and amlodipine in randomized trials, and, in network analysis of trials, it is less effective than CTDN and HCTZ-amiloride.
3.Azilsartan medoxomil in the management of hypertension: an evidence-based review of its place in therapy.
Angeloni E1. Core Evid. 2016 Apr 5;11:1-10. doi: 10.2147/CE.S81776. eCollection 2016.
BACKGROUND: Azilsartan (AZI) is a relatively new angiotensin receptor blocker available for the treatment of any stage of hypertension, which was eventually given in combination with chlorthalidone (CLT).
4.Effect of amlodipine on mouse renal interstitial fibrosis.
Honma S1, Nakamura K2, Shinohara M2, Mitazaki S2, Abe S2, Yoshida M2. Eur J Pharmacol. 2016 Mar 28. pii: S0014-2999(16)30171-6. doi: 10.1016/j.ejphar.2016.03.041. [Epub ahead of print]
Unilateral ureteral obstruction (UUO) is a well-established method to study interstitial fibrosis of the kidney. In this study, we investigated the effects of a calcium channel blocker, amlodipine, on UUO-induced renal interstitial fibrosis in mice. UUO significantly increased the fibrotic area in the obstructed kidney, but this change was inhibited by amlodipine (6.7mg/kg/day in drinking water). mRNA expression of heat shock protein (HSP) 47 and type IV collagen was increased in the kidneys of UUO mice. Amlodipine reduced the expression of both HSP47 and type IV collagen mRNAs. Phosphorylation of c-jun-N-terminal kinase (JNK) was significantly increased by UUO, but the change was inhibited by amlodipine. Collectively, these results suggest that amlodipine may inhibit the expression of HSP47 and type IV collagen by reducing phosphorylation of JNK and ameliorating the renal interstitial fibrosis induced by UUO.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Calcium Channel Products


CAS 187523-36-0 (R)-(-)-Flindokalner

(R)-(-)-Flindokalner
(CAS: 187523-36-0)

(R)-(-)-BMS 204352 is the less active R-(-)-enantiomer of BMS-204352, which is a positive modulator at neuronal Kv7 channels and calcium-activated K+ channels (...

CAS 177172-49-5 R 568 hydrochloride

R 568 hydrochloride
(CAS: 177172-49-5)

R 568 is positive allosteric modulator and allosteric agonist of the human calcium-sensing receptor (hCaSR), increasing the sensitivity to activation by extrace...

CAS 212778-82-0 Elpetrigine

Elpetrigine
(CAS: 212778-82-0)

Elpetrigine, also known as GW 273293 and JZP-4, has a blocking effect on calcium channels and potassium channels which has been in clinical bipolar disorders an...

S(-)-BAY K 8644
(CAS: 98625-26-4)

S(-)-BAY K 8644 is an activator of voltage-sensitive L-type calcium channels with positive inotropic, vasoconstrictive and behavioral effects in vivo. It is the...

CAS 111011-53-1 EFONIDIPINE HCL

EFONIDIPINE HCL
(CAS: 111011-53-1)

The hydrochloride salt form of Efonidipine which could be effective in the treatment of cardiovascular disease as a blocker of T-type and L-type calcium channel...

CAS 357400-13-6 NNC 55-0396 dihydrochloride

NNC 55-0396 dihydrochloride
(CAS: 357400-13-6)

NNC 55-0396 is a derivative of Mibefradil as a T-type calcium channel blocker (IC50=6.8 nM)

CAS 484-12-8 Osthole

Osthole
(CAS: 484-12-8)

Osthole is a coumarin which is isolated from Cnidium monnieri (L.) Cusson. Osthole is a calcium channel modulator via inhibiting phosphodiesterases. It also reg...

CAS 122647-32-9 Ibutilide Fumarate

Ibutilide Fumarate
(CAS: 122647-32-9)

Ibutilide Fumarate is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset ...

Chemical Structure

CAS 111470-99-6 Amlodipine Besylate

Quick Inquiry

Verification code

Featured Items