Amlexanox - CAS 68302-57-8
Catalog number:
68302-57-8
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C16H14N2O4
Molecular Weight:
298.29
COA:
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Targets:
IKK
Description:
Amlexanox is a specific inhibitor of IKKε and TBK1, which inhibits IKKε and TBK1 activity as determined by MBP phosphorylation.
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Purity:
>98%
Synonyms:
AA673; Amoxanox; CHX3673; Aphthasol
MSDS:
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1.Full UPF3B function is critical for neuronal differentiation of neural stem cells.
Alrahbeni T1,2, Sartor F3, Anderson J4, Miedzybrodzka Z5, McCaig C6, Müller B7. Mol Brain. 2015 May 27;8:33. doi: 10.1186/s13041-015-0122-1.
BACKGROUND: Mutation in the UPF3B gene on chromosome X is implicated in neurodevelopmental disorders including X-linked intellectual disability, autism and schizophrenia. The protein UPF3B is involved in the nonsense-mediated mRNA decay pathway (NMD) that controls mRNA stability and functions in the prevention of the synthesis of truncated proteins.
2.Micelle-enhanced spectrofluorimetric determination of amlexanox in bioadhesive buccal tablets: application to content uniformity testing.
Walash MI1, Belal F1, Tolba MM1, Halawa MI1. Luminescence. 2015 Sep;30(6):823-9. doi: 10.1002/bio.2828. Epub 2015 Jan 21.
A highly sensitive, simple and rapid spectrofluorimetric method was developed for the determination of Amlexanox (AMX) in its bioadhesive buccal tablets. The proposed method is based on measuring the native fluorescence of the methanolic solution of AMX at 400 nm after excitation at 242 nm in 0.2 M borate buffer (pH 10) and 0.5% w/v sodium dodecyl sulfate (SDS) solution. The interaction of AMX with SDS was studied, and the enhanced fluorescence intensity was exploited to develop an assay method for the determination of AMX. The relative fluorescence intensity-concentration plot was rectilinear over the range 5.0-80.0 ng/mL, with a lower detection limit of 0.57 ng/mL and a lower quantification limit of 1.74 ng/mL. The proposed method was successfully applied to the analysis of AMX in its commercial tablets. Moreover, content uniformity testing was conducted by applying official USP guidelines. Statistical evaluation and comparison of the data obtained using the proposed and comparison methods revealed good accuracy and precision for the proposed method.
3.Micelle-enhanced spectrofluorimetric determination of amlexanox in bioadhesive buccal tablets: application to content uniformity testing.
Walash MI1, Belal F1, Tolba MM1, Halawa MI1. Luminescence. 2015 Sep;30(6):823-9. doi: 10.1002/bio.2828. Epub 2015 Jan 21.
A highly sensitive, simple and rapid spectrofluorimetric method was developed for the determination of Amlexanox (AMX) in its bioadhesive buccal tablets. The proposed method is based on measuring the native fluorescence of the methanolic solution of AMX at 400 nm after excitation at 242 nm in 0.2 M borate buffer (pH 10) and 0.5% w/v sodium dodecyl sulfate (SDS) solution. The interaction of AMX with SDS was studied, and the enhanced fluorescence intensity was exploited to develop an assay method for the determination of AMX. The relative fluorescence intensity-concentration plot was rectilinear over the range 5.0-80.0 ng/mL, with a lower detection limit of 0.57 ng/mL and a lower quantification limit of 1.74 ng/mL. The proposed method was successfully applied to the analysis of AMX in its commercial tablets. Moreover, content uniformity testing was conducted by applying official USP guidelines. Statistical evaluation and comparison of the data obtained using the proposed and comparison methods revealed good accuracy and precision for the proposed method.
4.Low-level laser therapy versus 5% amlexanox: a comparison of treatment effects in a cohort of patients with minor aphthous ulcers.
Jijin MJ1, Rakaraddi M2, Pai J3, Jaishankar HP4, Krupashankar R5, Kavitha AP6, Anjana R7, Shobha R8. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016 Mar;121(3):269-73. doi: 10.1016/j.oooo.2015.11.021. Epub 2015 Dec 19.
OBJECTIVE: The aim of the study was to compare the treatment effects of 5% amlexanox and low-level laser therapy (LLLT) in a cohort of patients who experienced minor aphthous stomatitis.
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CAS 68302-57-8 Amlexanox

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