Amiodarone - CAS 1951-25-3
Catalog number: 1951-25-3
Category: Inhibitor
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Molecular Formula:
C25H29I2NO3
Molecular Weight:
645.32
COA:
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Targets:
Potassium Channel
Description:
Amiodarone, an iodine-rich benzofuran derivative, as a vaughan-Williams Class III antiarrhythmic agent it is an ATP-sensitive potassium channel inhibitor (IC50= 19.1 μM).
Purity:
≥99%
Appearance:
White photosensitive solid
Synonyms:
(2-butyl-1-benzofuran-3-yl)-[4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl]methanone Alphapharm Brand of Amiodarone Hydrochloride Amiobeta Amiodarex Amiodarona Amiodarone Amiodarone Hydrochloride Amiohexal Aratac Armstrong Brand of Amiodarone Hydrochloride
Solubility:
Soluble in DMSO
Storage:
Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -22℃ for long term (months to years).
MSDS:
Inquire
Shelf Life:
2 years
Boiling Point:
635.1±55.0 °C | Condition: Press: 760 Torr
Density:
1.580±0.06 g/cm3
InChIKey:
IYIKLHRQXLHMJQ-UHFFFAOYSA-N
InChI:
1S/C25H29I2NO3/c1-4-7-11-22-23(18-10-8-9-12-21(18)31-22)24(29)17-15-19(26)25(20(27)16-17)30-14-13-28(5-2)6-3/h8-10,12,15-16H,4-7,11,13-14H2,1-3H3
Canonical SMILES:
CCCCC1=C(C2=CC=CC=C2O1)C(=O)C3=CC(=C(C(=C3)I)OCCN(CC)CC)I
1.[Establishment and evaluation of a warfarin-dosing algorithm in Chinese Han population].
Li CB1, Dai DP2, Hu GX, Pu CW, Cao YP, Cai JP. Zhonghua Yi Xue Za Zhi. 2016 Mar 15;96(10):776-80. doi: 10.3760/cma.j.issn.0376-2491.2016.10.006.
OBJECTIVE: To develop and evaluate a warfarin-dosing algorithm method which can be used to guide the adjustment of warfarin maintenance dose in Chinese Han population.
2.Rational design, synthesis and 2D-QSAR study of novel vasorelaxant active benzofuran-pyridine hybrids.
Srour AM1, Abd El-Karim SS2, Saleh DO3, El-Eraky WI3, Nofal ZM2. Bioorg Med Chem Lett. 2016 Mar 15. pii: S0960-894X(16)30274-8. doi: 10.1016/j.bmcl.2016.03.054. [Epub ahead of print]
Reaction of 3-aryl-1-(benzofuran-2-yl)-2-propen-1-ones 3a-c with malononitrile in the presence of sufficient amount of sodium alkoxide in the corresponding alcohol proceeds in a regioselective manner to afford 2-alkoxy-4-aryl-6-(benzofuran-2-yl)-3-pyridinecarbonitriles 4-37, which also obtained by treating ylidenemalononitriles 6a-q with 2-acetylbenzofuran 1 in the presence of sufficient amount of sodium alkoxide in the corresponding alcohol. The new chemical entities showed significant vasodilation properties using isolated thoracic aortic rings of rats pre-contracted with norepinephrine hydrochloride standard technique. Compounds 11, 16, 21, 24 and 30 exhibited remarkable activity compared with amiodarone hydrochloride the reference standard used in the present study. CODESSA-Pro software was employing to obtain a statistically significant QSAR model describing the bioactivity of the newly synthesized analogs (N=31, n=5, R2=0.846, R2cvOO=0.
3.Prediction of Positive Food Effect: Bioavailability Enhancement of BCS Class II Drugs.
Raman S1, Polli JE2. Int J Pharm. 2016 Apr 8. pii: S0378-5173(16)30288-5. doi: 10.1016/j.ijpharm.2016.04.013. [Epub ahead of print]
High-throughput screening methods have increased the number of poorly water-soluble, highly permeable drug candidates. Many of these candidates have increased bioavailability when administered with food (i.e. exhibit a positive food effect). Food is known to impact drug bioavailability through a variety of mechanisms, including drug solubilization and prolonged gastric residence time. In vitro dissolution media that aim to mimic in vivo gastrointestinal (GI) conditions have been developed to lessen the need for fed human bioequivalence studies. The objective of this work was to develop an in vitro lipolysis model to predict positive food effect of three BCS Class II drugs (i.e. danazol, amiodarone and ivermectin) in previously developed lipolysis media. This in vitro lipolysis model was comparatively benchmarked against FeSSIF and FaSSIF media that were modified for an in vitro lipolysis approach, as FeSSIF and FaSSIF are widely used in in vitro dissolution studies.
4.ECMO Used in a Refractory Ventricular Tachycardia and Ventricular Fibrillation Patient: A National Case-Control Study.
Chen CY1, Tsai J, Hsu TY, Lai WY, Chen WK, Muo CH, Kao CH. Medicine (Baltimore). 2016 Mar;95(13):e3204. doi: 10.1097/MD.0000000000003204.
Refractory cardiac arrhythmia, which has a poor response to defibrillation and antiarrhythmia medication, is a complicated problem for clinical physicians during resuscitation. Extracorporeal membrane oxygenation (ECMO) may be used to sustain life in this situation. ECMO is useful for cardiopulmonary resuscitation among patients suffering from cardiac arrest; the use of ECMO in this context is called E-cardiopulmonary resuscitation. However, a large-scale and nationwide survey of ECMO usage in cases involving refractory cardiac arrhythmia during resuscitation is lacking. We aimed to clarify the characteristics and efficacy of the application of ECMO in cases involving refractory cardiac arrhythmia during resuscitation by conducting a nationwide study.Using national insurance data from 1996 to 2011, 2702 patients who received defibrillation and amiodarone injections were selected. We excluded trauma patients (n = 316) and those aged<20 years (n = 24).
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CAS 1951-25-3 Amiodarone

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