Amiodarone - CAS 1951-25-3
Catalog number: 1951-25-3
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Potassium Channel
Amiodarone, an iodine-rich benzofuran derivative, as a vaughan-Williams Class III antiarrhythmic agent it is an ATP-sensitive potassium channel inhibitor (IC50= 19.1 μM).
Publictions citing BOC Sciences Products
  • >> More
White photosensitive solid
(2-butyl-1-benzofuran-3-yl)-[4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl]methanone Alphapharm Brand of Amiodarone Hydrochloride Amiobeta Amiodarex Amiodarona Amiodarone Amiodarone Hydrochloride Amiohexal Aratac Armstrong Brand of Amiodarone Hydrochloride
Soluble in DMSO
Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -22℃ for long term (months to years).
Shelf Life:
2 years
Boiling Point:
635.1±55.0 °C | Condition: Press: 760 Torr
1.580±0.06 g/cm3
Canonical SMILES:
1.[Establishment and evaluation of a warfarin-dosing algorithm in Chinese Han population].
Li CB1, Dai DP2, Hu GX, Pu CW, Cao YP, Cai JP. Zhonghua Yi Xue Za Zhi. 2016 Mar 15;96(10):776-80. doi: 10.3760/cma.j.issn.0376-2491.2016.10.006.
OBJECTIVE: To develop and evaluate a warfarin-dosing algorithm method which can be used to guide the adjustment of warfarin maintenance dose in Chinese Han population.
2.Rational design, synthesis and 2D-QSAR study of novel vasorelaxant active benzofuran-pyridine hybrids.
Srour AM1, Abd El-Karim SS2, Saleh DO3, El-Eraky WI3, Nofal ZM2. Bioorg Med Chem Lett. 2016 Mar 15. pii: S0960-894X(16)30274-8. doi: 10.1016/j.bmcl.2016.03.054. [Epub ahead of print]
Reaction of 3-aryl-1-(benzofuran-2-yl)-2-propen-1-ones 3a-c with malononitrile in the presence of sufficient amount of sodium alkoxide in the corresponding alcohol proceeds in a regioselective manner to afford 2-alkoxy-4-aryl-6-(benzofuran-2-yl)-3-pyridinecarbonitriles 4-37, which also obtained by treating ylidenemalononitriles 6a-q with 2-acetylbenzofuran 1 in the presence of sufficient amount of sodium alkoxide in the corresponding alcohol. The new chemical entities showed significant vasodilation properties using isolated thoracic aortic rings of rats pre-contracted with norepinephrine hydrochloride standard technique. Compounds 11, 16, 21, 24 and 30 exhibited remarkable activity compared with amiodarone hydrochloride the reference standard used in the present study. CODESSA-Pro software was employing to obtain a statistically significant QSAR model describing the bioactivity of the newly synthesized analogs (N=31, n=5, R2=0.846, R2cvOO=0.
3.Prediction of Positive Food Effect: Bioavailability Enhancement of BCS Class II Drugs.
Raman S1, Polli JE2. Int J Pharm. 2016 Apr 8. pii: S0378-5173(16)30288-5. doi: 10.1016/j.ijpharm.2016.04.013. [Epub ahead of print]
High-throughput screening methods have increased the number of poorly water-soluble, highly permeable drug candidates. Many of these candidates have increased bioavailability when administered with food (i.e. exhibit a positive food effect). Food is known to impact drug bioavailability through a variety of mechanisms, including drug solubilization and prolonged gastric residence time. In vitro dissolution media that aim to mimic in vivo gastrointestinal (GI) conditions have been developed to lessen the need for fed human bioequivalence studies. The objective of this work was to develop an in vitro lipolysis model to predict positive food effect of three BCS Class II drugs (i.e. danazol, amiodarone and ivermectin) in previously developed lipolysis media. This in vitro lipolysis model was comparatively benchmarked against FeSSIF and FaSSIF media that were modified for an in vitro lipolysis approach, as FeSSIF and FaSSIF are widely used in in vitro dissolution studies.
4.ECMO Used in a Refractory Ventricular Tachycardia and Ventricular Fibrillation Patient: A National Case-Control Study.
Chen CY1, Tsai J, Hsu TY, Lai WY, Chen WK, Muo CH, Kao CH. Medicine (Baltimore). 2016 Mar;95(13):e3204. doi: 10.1097/MD.0000000000003204.
Refractory cardiac arrhythmia, which has a poor response to defibrillation and antiarrhythmia medication, is a complicated problem for clinical physicians during resuscitation. Extracorporeal membrane oxygenation (ECMO) may be used to sustain life in this situation. ECMO is useful for cardiopulmonary resuscitation among patients suffering from cardiac arrest; the use of ECMO in this context is called E-cardiopulmonary resuscitation. However, a large-scale and nationwide survey of ECMO usage in cases involving refractory cardiac arrhythmia during resuscitation is lacking. We aimed to clarify the characteristics and efficacy of the application of ECMO in cases involving refractory cardiac arrhythmia during resuscitation by conducting a nationwide study.Using national insurance data from 1996 to 2011, 2702 patients who received defibrillation and amiodarone injections were selected. We excluded trauma patients (n = 316) and those aged<20 years (n = 24).
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Potassium Channel Products

CAS 183720-28-7 (±)-BMS 204352

(±)-BMS 204352
(CAS: 183720-28-7)

(±)-BMS 204352 is a potassium channel opener that can be used in the study of buspirone metabolites for treating movement disorders.

CAS 522-51-0 Dequalinium Chloride

Dequalinium Chloride
(CAS: 522-51-0)

Dequalinium Chloride is a PKC inhibitor with IC50 of 7-18 μM, and also a selective blocker of apamin-sensitive K+ channels with IC50 of 1.1 μM.

CAS 57568-80-6 PNU 37883 hydrochloride

PNU 37883 hydrochloride
(CAS: 57568-80-6)

PNU 37883 is a potent, euglycemic vascular K-ATP blocker that also exerts a K+-sparing diuresis at higher doses. It selectively inhibits Kir6 currents in isolat...

CAS 115256-11-6 Dofetilide

(CAS: 115256-11-6)

Dofetilide is a selective potassium channel ((hERG)) blocker, used as a Class III antiarrhythmic drug

CAS 94470-67-4 Cromakalim

(CAS: 94470-67-4)

Cromakalim is a prototypical Kir6 (KATP) channel opener. It is used as a potassium channel-opening vasodilator. It acts on ATP-sensitive potassium channels and ...

CAS 60563-36-2 DCEBIO

(CAS: 60563-36-2)

DCEBIO is a Ca2+ sensitive K+ channel (SKCa) agonist stimulating Cl- secretion via activation of hKCa3.1 (IK1) potassium channels and activation of an apical Cl...

CAS 64190-70-1 Phe-Met-Arg-Phe, amide

Phe-Met-Arg-Phe, amide
(CAS: 64190-70-1)

Phe-Met-Arg-Phe, amide, also called as FMRF-NH2, belongs to Molluscan Cardioexcitatory Neuropeptide and dose dependently (ED50=23 nM) activates a K+current in t...

CAS 1061556-49-7 Lei-Dab 7

Lei-Dab 7
(CAS: 1061556-49-7)

HLei-Dab 7 is a calcium-activated potassium channel blocker.

CAS 918311-87-2 UCL 2077

UCL 2077
(CAS: 918311-87-2)

UCL 2077 is a slow afterhyperpolarization (sAHP) channel blocker that reduces sAHP in hippocampal slice preparations. UCL 2077 exhibits no effect on Ca2+ curren...


ADWX 1 has been found to be a Kv1.3 channel blocker and could probably ameliorate autoimmune encephalomyelitis at some extent.

AAQ chloride

AAQ chloride is a photoswitchable Kv channel blocker (IC50 = 2 and 64 μM at 500 nm and 380 nm, respectively) that switches conformation from cis to trans at 500...

CAS 1951-25-3 Amiodarone

(CAS: 1951-25-3)

Amiodarone, an iodine-rich benzofuran derivative, as a vaughan-Williams Class III antiarrhythmic agent it is an ATP-sensitive potassium channel inhibitor (IC50=...

(CAS: 778564-77-5)

GYKI-16638 is Potassium channel and Sodium channel antagonist originated by Nonindustrial source. It is a novel antiarrhythmic agent.

CAS 289656-45-7 Senicapoc

(CAS: 289656-45-7)

Senicapoc, previously called as ICA 17043, is a is a small organic potent and selective blocker of the Gardos channel which is the calciumactivated potassium ch...

CAS 101526-62-9 Sematilide hydrochloride

Sematilide hydrochloride
(CAS: 101526-62-9)

Sematilide, also known as CK-1752, is a class III antiarrhythmic compound showing selective delayed rectifier K+ current channel blocking. It inhibits rapidly a...

CAS 56995-20-1 Flupirtine

(CAS: 56995-20-1)

Flupirtine is a selective neuronal potassium channel opener act as an Analgesic, having substituted pyridine with central analgesic properties.

(CAS: 872045-91-5)

AZD1305 is a potassium channel and sodium channel antagonist. It can inhibit rapidly the activating delayed-rectifier potassium current, L-type calcium current,...

ZM 260384
(CAS: 161229-62-5)

ZM 260384, a benzoxazine derivative, has been found to be a potassium channel agonist that was once studied against hypertension and thrombus.

CAS 875755-24-1 NS 8593 hydrochloride

NS 8593 hydrochloride
(CAS: 875755-24-1)

NS8593 HCl is a selective KCa2 channel negative modulator.

CAS 18200-13-0 BL 1249

BL 1249
(CAS: 18200-13-0)

BL 1249 is a putative potassium channel activator and acts as a K2P2.1 (TREK-1) channel opener. It exhibits selectivity for bladder over vascular tissue in vitr...

Chemical Structure

CAS 1951-25-3 Amiodarone

Quick Inquiry

Verification code

Featured Items