​Aminocaproic acid - CAS 60-32-2
Catalog number:
60-32-2
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C6H13NO2
Molecular Weight:
131.17
COA:
Inquire
Targets:
Others
Description:
Aminocaproic acid is a derivative and analogue of the amino acid lysine, which makes it an effective inhibitor for enzymes that bind that particular residue. Such enzymes include proteolytic enzymes like plasmin, the enzyme responsible for fibrinolysis.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
MSDS:
Inquire
1.Study on mutual interactions and electronic structures of hyaluronan with Lysine, 6-Aminocaproic acid and Arginine.
Chytil M1, Trojan M2, Kovalenko A3. Carbohydr Polym. 2016 May 20;142:8-15. doi: 10.1016/j.carbpol.2016.01.035. Epub 2016 Jan 18.
Interactions between polyelectrolytes and oppositely charged surfactants have been in a great interest for several decades, yet the conventional surfactants may cause a problem in medical applications. Interactivity between polysaccharide hyaluronan (HA) and amino acids Lysine, 6-Aminocaproic acid (6-AcA), and Arginine as an alternative system is reported. The interactions were investigated by means of rheology and electric conductance and the electronic structures were explored by the density functional theory (DFT). Lysine exhibits the strongest interaction of all, which was manifested, e.g. by nearly 6-time drop of the initial viscosity comparing with only 1.3-time lower value in the case of 6-AcA. Arginine interaction with HA was surprisingly weaker in terms of viscosity than that of Lysine due to a lower and delocalized charge density on its guanidine group. According to the DFT calculations, the binding of Lysine to HA was found to be more flexible, while Arginine creates more rigid structure with HA.
2.Preoperative management of factor XI deficiency with therapeutic plasma exchange: A case report and literature review.
Pagano MB1, Konkle BA2, Wu Y3, Josephson N4. J Clin Apher. 2015 Dec 18. doi: 10.1002/jca.21442. [Epub ahead of print]
Patients with factor XI deficiency may have bleeding complications during surgery. Because bleeding severity and factor levels correlate poorly, factor replacement needs to be personalized based on bleeding history and type of procedure. We report a 65-year-old male with factor XI deficiency (7 IU dL-1 ) who presented before scheduled hip arthroplasty. He had a history of total hip arthroplasty complicated by bleeding, delayed healing and prosthesis removal, despite receiving prophylactic treatment with plasma infusion. For the current surgery a factor XI ≥50 IU dL-1 level was targeted. The calculated plasma infusion needed to achieve this goal was 3100 mL (14 U). Because of concerns about circulatory overload and inability to achieve target by simple infusion, prophylactic treatment with therapeutic plasma exchange (TPE) was requested. TPE was performed the morning before the surgery, using 100% plasma as replacement fluid (3912 mL of plasma), and a positive fluid balance of 631 mL.
3.Aminocaproic acid for the management of bleeding in patients on extracorporeal membrane oxygenation: Four adult case reports and a review of the literature.
Buckley LF1, Reardon DP2, Camp PC3, Weinhouse GL4, Silver DA5, Couper GS6, Connors JM7. Heart Lung. 2016 Feb 19. pii: S0147-9563(16)00012-1. doi: 10.1016/j.hrtlng.2016.01.011. [Epub ahead of print]
BACKGROUND: Extracorporeal membrane oxygenation (ECMO) is associated with a significant risk of bleeding and thrombosis. Despite high rates of bleeding and bleeding-related mortality in patients on ECMO, there is little evidence available to guide clinicians in the management of ECMO-associated bleeding.
4.Epsilon-Aminocaproic Acid Has No Association With Thromboembolic Complications, Renal Failure, or Mortality after Liver Transplantation.
Nicolau-Raducu R1, Ku TC2, Ganier DR3, Evans BM3, Koveleskie J3, Daly WJ Jr3, Fish B3, Cohen AJ4, Reichman TW4, Bohorquez HE4, Bruce DS4, Carmody IC4, Loss GE4, Gitman M5, Marshall T3, Nossaman BD3. J Cardiothorac Vasc Anesth. 2015 Dec 3. pii: S1053-0770(15)00964-7. doi: 10.1053/j.jvca.2015.12.003. [Epub ahead of print]
OBJECTIVES: To examine the role of epsilon-aminocaproic acid (EACA) administered after reperfusion of the donor liver in the incidences of thromboembolic events and acute kidney injury within 30 days after orthotopic liver transplantation. One-year survival rates between the EACA-treated and EACA-nontreated groups also were examined.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products


CAS 26027-38-3 Nonoxinol 9

Nonoxinol 9
(CAS: 26027-38-3)

Nonoxinol 9, also called as Advantage S or Delfen Cream, belongs to the nonoxynol family of nonionic surfactants.

CAS 4910-46-7 N-Acetyl-β-Asp-Glu

N-Acetyl-β-Asp-Glu
(CAS: 4910-46-7)

N-Acetyl-β-Asp-Glu is a peptide neurotransmitter and the third-most-prevalent neurotransmitter in the mammalian nervous system.

Hemoglobin Modulators-1
(CAS: 1446321-46-5)

Hemoglobin Modulators-1, a substituted benzaldehyde compound that can modulate sickle hemoglobin (HbS) for treatment of disorders.

CAS 40246-10-4 Glycitin

Glycitin
(CAS: 40246-10-4)

Glycitin is an isoflavonoid recently found in flowers of Pueraria thunbergianal. It can be modified into the metabolite glycitein which has anti-inflammatory pr...

CAS 465-21-4 Bufalin

Bufalin
(CAS: 465-21-4)

Bufalin is a major digoxin-like immunoreactive component of the Chinese medicine Chan Su and has been shown to exert a potential for anticancer activity against...

CAS 905-99-7 Cryptochlorogenic acid

Cryptochlorogenic acid
(CAS: 905-99-7)

Cryptochlorogenic acid is an isomer of chlorogenic acid. It is a natural product extracted from the flowerbud of Lonicera japonica Thunb. It has antioxidant act...

CAS 86-34-0 phensuximide

phensuximide
(CAS: 86-34-0)

Phensuximide is an anticonvulsant drug. It can be used for the treatment of neurological disorders stemming from the brain. Phensuximide can suppress the paroxy...

OVA Peptide 323-339

OVA Peptide (323-339) encompasses an allergenic and antigenic epitope of the ovalbumin protein, and represents a T and B cell epitope of Ovalbumin (Ova) and , w...

CAS 673202-67-0 Hexa-D-arginine

Hexa-D-arginine
(CAS: 673202-67-0)

An inhibitor of furin

CAS 442201-24-3 Remogliflozin etabonate

Remogliflozin etabonate
(CAS: 442201-24-3)

Remogliflozin etabonat, pro-drug of remogliflozin, is a SGLT2 inhibitor under development for the treatment of type 2 diabetes. Remogliflozin etabonate is a pr...

CAS 549-18-8 Amitriptyline Hydrochloride

Amitriptyline Hydrochloride
(CAS: 549-18-8)

Amitriptyline inhibits serotonin receptor, norepinephrine receptor, 5-HT4, 5-HT2 and sigma 1 receptor with IC50 of 3.45 nM, 13.3 nM, 7.31 nM, 235 nM and 287 nM,...

CAS 939983-14-9 p53 and MDM2 proteins-interaction-inhibitor racemic

p53 and MDM2 proteins-interaction-inhibi
(CAS: 939983-14-9)

p53 and MDM2 proteins-interaction-inhibitor racemic is an inhibitor of the interaction between p53 and MDM2 proteins.

CAS 477-43-0 Dehydrocostus lactone

Dehydrocostus lactone
(CAS: 477-43-0)

Dehydrocostus lactone and CL from root of S. lappa have anti-colorectal cancer activities through inhibiting Wnt/β-catenin pathway.

CAS 4205-90-7 Clonidine

Clonidine
(CAS: 4205-90-7)

Clonidine is an α2-Adrenergic agonist for neuropathic pain.

CAS 553-12-8 Protoporphyrin IX

Protoporphyrin IX
(CAS: 553-12-8)

Created by the enzyme protoporphyrinogen oxidase, protoporphyrin IX is an important precursor to biologically essential prosthetic groups.

CAS 71320-77-9 Moclobemide

Moclobemide
(CAS: 71320-77-9)

Moclobemide is a reversible monoamine oxidase A (MOA-A) inhibitor.

DiZPK
(CAS: 1337883-32-5)

DiZPK, a photocrosslinking amino acid, could be significant in revealling the physiological and functions of some proteins acting as a genetically encoded.

CAS 109581-93-3 Tacrolimus monohydrate

Tacrolimus monohydrate
(CAS: 109581-93-3)

Tacrolimus monohydrate is a potent immunosuppressive drug often administered to transplant recipient patients and exhibits a variety of adverse cardiovascular e...

CAS 185517-21-9 R-(-)-Arundic Acid

R-(-)-Arundic Acid
(CAS: 185517-21-9)

R-(-)-Arundic Acid, also called as ONO 2506, is an astrocyte modulating agent which can treat neurodegenerative diseases including Alzheimer's disease and Parki...

BTZ-N3
(CAS: 1839081-05-8)

BTZ-N3, a electron deficient nitroaromatic compound, is a potent and selective anti-TB drug candidate.

Chemical Structure

CAS 60-32-2 ​Aminocaproic acid

Quick Inquiry

Verification code

Featured Items