AMG-9810 - CAS 545395-94-6
Catalog number:
545395-94-6
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C21H23NO3
Molecular Weight:
337.41
COA:
Inquire
Targets:
TRP Channel
Description:
AMG-9810 is potent, non-vanilloid and selective TRPV1 receptor antagonist with IC50 value of 17 nM. It inhibits capsaicin-, proton-, heat- and endogenous ligand-induced activation of human and rat recombinant TRPV1 receptors. It displays antihyperalgesic properties in a rat model of inflammatory pain. It was developed by Amgen.
Publictions citing BOC Sciences Products
  • >> More
Purity:
98%
Appearance:
White to beige powder
Synonyms:
(2E)-N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-3-[4-(1,1-dimethylethyl)phenyl]-2-propanamide;2-PropenaMide, N-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-[4-(1,1-diMethylethyl)phenyl]-, (2E)-;(E)-3-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)prop-2-enami
Solubility:
DMSO: >5 mg/mL
Storage:
2-8ºC
MSDS:
Inquire
Application:
AMG-9810 displays antihyperalgesic properties.
Quality Standard:
In-house standard
Quantity:
Grams to Kilograms
Boiling Point:
512.5±50.0 °C | Condition: Press: 760 Torr
Density:
1.175±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
InChIKey:
GZTFUVZVLYUPRG-IZZDOVSWSA-N
InChI:
InChI=1S/C21H23NO3/c1-21(2,3)16-7-4-15(5-8-16)6-11-20(23)22-17-9-10-18-19(14-17)25-13-12-24-18/h4-11,14H,12-13H2,1-3H3,(H,22,23)/b11-6+
Canonical SMILES:
CC(C)(C)C1=CC=C(C=C1)C=CC(=O)NC2=CC3=C(C=C2)OCCO3
Current Developer:
AMG-9810 was developed by Amgen.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related TRP Channel Products


CAS 349085-38-7 HC-030031

HC-030031
(CAS: 349085-38-7)

HC-030031 is a selective TRPA1 channel blocker that antagonizes AITC- and formalin-evoked calcium influx with IC50 of 6.2 μM and 5.3 μM respectively.

CAS 55224-94-7 AP18

AP18
(CAS: 55224-94-7)

AP18 is a selective Transient receptor potential A1(TRPA1) channel blocker which reversibly inhibits TRPA1 with IC50 values of 3.1 and 4.5 µM at human and mouse...

CAS 1192871-27-4 TRPV antagonist 1

TRPV antagonist 1
(CAS: 1192871-27-4)

TRPV antagonist 1 is a transient receptor potential vanilloid (TRPV) antagonist (IC50= < 250 nM).

MK-2295
(CAS: 878811-00-8)

MK-2295 is a potent TRPV1 antagonist. TRPV1 antagonists has the potential as analgesic and anti-inflammatory agents.

CAS 393514-24-4 BCTC

BCTC
(CAS: 393514-24-4)

BCTC is a TRPA1 and TRPV1 antagonist that inhibits capsaicin-induced and acid-induced activation of rat TRPV1 with IC50 values of 35 and 6 nM, respectively.

SN 2
(CAS: 823218-99-1)

SN 2 is a novel and potent small molecule activator of TRPML3. Its EC50 value is 1.13 uM. It had a similar synergistic effect and reached up-to 10-fold enhancem...

CAS 348575-88-2 Optovin

Optovin
(CAS: 348575-88-2)

Optovin is a reversible photoactive TRPA1 activator; stimulates human TRPA1 channels in vitro and enables repeated photoactivation of motor behaviors in wild-ty...

CAS 659730-32-2 AMG-517

AMG-517
(CAS: 659730-32-2)

AMG-517 is a potent and selective TRPV1 antagonist, antagonizes capsaicin, proton, and heat activation of TRPV1 with IC50 of 0.76 nM, 0.62 nM and 1.3 nM.

Mavatrep
(CAS: 956274-94-5)

Mavatrep is an orally bioavailable, potent and selective TRPV1 antagonist with Ki value of 6.5 nM, which exhibits minimal effect on the enzymatic activity of CY...

CAS 1336960-13-4 GSK2193874

GSK2193874
(CAS: 1336960-13-4)

GSK2193874 is a potent, orally active and specific antagonist of TRPV4 ion channels (IC50 values= 2 and 40 nM for rat and human receptors, respectively). GSK219...

ML204
(CAS: 5465-86-1)

ML204 is a novel and potential TRPC4 Channel inhibitor. ML204 inhibited TRPC4β-mediated intracellular Ca(2+) rise with an IC(50) value of 0.96 μm and exhibited ...

CAS 942206-85-1 GSK1016790A

GSK1016790A
(CAS: 942206-85-1)

GSK1016790A is a novel and potent transient receptor potential vanilloid 4 (TRPV4) agonist. It has been used to demonstrate a role for TRPV4 in regulating urina...

CAS 36945-98-9 Icilin

Icilin
(CAS: 36945-98-9)

Icilin is a synthetic CMR1/TRPM8 super agonist in CMR1-expressing HEK 293 cells (EC50 = 0.36 μM) more potently than menthol or low temperatures.

Pyr6
(CAS: 245747-08-4)

Pyr6, a pyrazole derivative, is a selective inhibitor of ransient receptor potential cation 3 (TRPC3) channels that inhibited Orai1- and TRPC3-mediated Ca(2+) e...

Pyr10
(CAS: 1315323-00-2)

Pyr10, a pyrazole derivative, is a TRPC3-selective inhibitor that could be effective in the study of cellular functions. IC50: 0.72 uM and 13.08 uM for TRPC3-RO...

CAS 138977-28-3 Capsazepine

Capsazepine
(CAS: 138977-28-3)

Capsazepine, a benzazepine derivative, has been found to be a sensory neurone excitotoxin that could be used against hyperalgesic responses. IC50: 562 nM (Rat T...

CAS 501951-42-4 SB705498

SB705498
(CAS: 501951-42-4)

SB705498 is a TRPV1 antagonist for hTRPV1, antagonizes capsaicin, acid, and heat activation of TRPV1 with IC50 of 3 nM, 0.1 nM and 6 nM, shows a degree of volta...

CAS 332117-28-9 TCS 5861528

TCS 5861528
(CAS: 332117-28-9)

TCS 5861528 is a selective TRPA1 blocker with IC50 values are 14.3 and 18.7μM respectively), attenuates diabetes mellitus hypersensitivity and displays antinoci...

CAS 545395-94-6 AMG-9810

AMG-9810
(CAS: 545395-94-6)

AMG-9810 is potent, non-vanilloid and selective TRPV1 receptor antagonist with IC50 value of 17 nM. It inhibits capsaicin-, proton-, heat- and endogenous ligand...

CAS 1221443-94-2 A-1165442

A-1165442
(CAS: 1221443-94-2)

A-1165442 is a potent, competitive and orally available modality-differentiated second-generation TRPV1 antagonist with good analgesic efficacy and a temperatur...

Chemical Structure

CAS 545395-94-6 AMG-9810

Quick Inquiry

Verification code

Featured Items