|Targets||beta-secretase 1 (BACE1)|
|Description||AMG-978 is an inhibitor of beta-secretase 1 (BACE1) (IC50 = 27 nM) which is in the preclinical study for the treatment of Alzheimer's disease.|
|Brife Description||inhibitor of beta-secretase 1 (BACE1), Alzheimer's disease|
|Application||the potential treatment of Alzheimer's disease|
AMG-978 is an inhibitor of beta-secretase 1 (BACE1) (IC50 = 27 nM) which is in the preclinical study for the treatment of Alzheimer's disease.
PF-CBP1, also known as PF-06670910, is an inhibitor of the CBP and p300 bromodomains (IC50s = 125 and 363 nM, respectively) with more than 100-fold selectivity ...
PD 169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor, with IC50 of 89 nM.
KN-92 is an inactive analog of the CaM kinase II inhibitor KN 93.
Bax inhibitor peptide, negative control
A negative control peptide for the Bax inhibitor peptide V5, which inhibits Bax translocation to mitochondria and Bax-mediated apoptosis in vitro.
LW6 was first identified and reported by a group scientists from Korea. LW6 was found to inhibits the accumulation of HIF-1alpha. LW6 decreased HIF-1alpha prote...
Naltrindole hydrochloride is a cell permeable, potent and highly selective non-peptideδ opioid receptor antagonist (Ki= 0.02 nM) with 223- and 346-fold greater ...
MK-2206 hydrochloride is the hydrochloride form of MK-2206, which is an allosteric inhibitor of Akt and an orally bioavailable allosteric inhibitor of the serin...