|Description||AMG 837 sodium salt is a potent GPR40 agonist with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents. It displayed the expected two-fold increase in potency on GPR4 compared to the racemic compound and its activity crossed over to the rat and mouse forms of GPR40. It is a highly potent stimulator of insulin secretion in MIN6 cells with an EC50 comparable to that seen in the aequorin Ca2+-flux assay. It was a potent partial agonist in the calcium flux assay on the GPR40 receptor and potentiated glucose stimulated insulin secretion in vitro and in vivo.|
GPR40 Activator 2
GPR40 Activator 2 is a potent GPR40 activator from patents WO 2012147516 A1, WO 2012046869A1 and WO 2011078371 A1.
A cell-permeable pyrimidinylmethyl-pyrimidinone compound that acts as potent, reversible and non-competitive GPR40 antagonist. Shown to significantly reverse gl...
AMG 837 calcium hydrate
AMG 837 calcium hydrate is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secret...
TUG424 is a a potent and selective free fatty acid receptor 1 agonist. It is expected to be useful in the exploration of FFA1 and may also be valuable as a lead...
AM4668 is a potent and selective G-protein coupled receptor 40(GPR40) agonist with EC50 value of 3.6 nM in an IP3 assay in GPR40 transfected A9 cells. It is mor...
TAK-875 is a potent, selective, and orally bioavailable GPR40 agonist, with a pharmacokinetic profile enabling long-acting drug efficacy.
AS 2034178 has been found to be a FFA1/GPR40 agonist and could probably be used against diabetes.
AMG 837 sodium salt is a potent GPR40 agonist with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents. ...