AMG 837 sodium salt - CAS 865231-45-4
Catalog number: 865231-45-4
Category: Inhibitor
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Molecular Formula:
C26H20F3NaO3
Molecular Weight:
460.42
COA:
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Targets:
GPR40
Description:
AMG 837 sodium salt is a potent GPR40 agonist with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents. It displayed the expected two-fold increase in potency on GPR4 compared to the racemic compound and its activity crossed over to the rat and mouse forms of GPR40. It is a highly potent stimulator of insulin secretion in MIN6 cells with an EC50 comparable to that seen in the aequorin Ca2+-flux assay. It was a potent partial agonist in the calcium flux assay on the GPR40 receptor and potentiated glucose stimulated insulin secretion in vitro and in vivo.
Purity:
>98%
MSDS:
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InChIKey:
GLLCPUJEWMFFBZ-BOXHHOBZSA-N
InChI:
InChI=1S/C26H21F3O3.Na/c1-2-4-21(16-25(30)31)20-9-13-24(14-10-20)32-17-18-5-3-6-22(15-18)19-7-11-23(12-8-19)26(27,28)29;/h3,5-15,21H,16-17H2,1H3,(H,30,31);/t21-;/m0./s1
Canonical SMILES:
CC#CC(CC(=O)O)C1=CC=C(C=C1)OCC2=CC=CC(=C2)C3=CC=C(C=C3)C(F)(F)F.[Na]
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Chemical Structure

CAS 865231-45-4 AMG 837 sodium salt

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