|Description||The calcuim salt form of AMG 837, which has been found to be a GPR40 partial agonist and could probably be used as an antidiabetic agent.|
|Purity||≥98% by HPLC|
|Synonyms||(βS)-β-1-Propyn-1-yl-4-[[4'-(trifluoromethyl)[1,1'-biphenyl]-3-yl]methoxy]benzenepropanoic acid hemicalcium salt|
AMG 837 hemicalcium salt
The calcuim salt form of AMG 837, which has been found to be a GPR40 partial agonist and could probably be used as an antidiabetic agent.
AM4668 is a potent and selective G-protein coupled receptor 40(GPR40) agonist with EC50 value of 3.6 nM in an IP3 assay in GPR40 transfected A9 cells. It is mor...
TAK-875 is a potent, selective, and orally bioavailable GPR40 agonist, with a pharmacokinetic profile enabling long-acting drug efficacy.
AS 2034178 has been found to be a FFA1/GPR40 agonist and could probably be used against diabetes.
AMG 837 sodium salt
AMG 837 sodium salt is a potent GPR40 agonist with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents. ...
MEDICA 16 is a selective free fatty acid 1 receptor agonist. It is also an ATP citrate lyase inhibitor. MEDICA 16 shows hypolipidemic and antidiabetogenic effec...
GPR40 Activator 1
GPR40 Activator 1 is a potent GPR40 activator for treatment of type 2 diabetes.
This active molecular is a free fatty acid (FFA) 1 receptor agonist. TUG-469 is more than two hundred fold selective for FFA1 over FFA4. TUG-469 can potential u...