|Description||AMG 837 sodium salt is a potent GPR40 agonist with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents. It displayed the expected two-fold increase in potency on GPR4 compared to the racemic compound and its activity crossed over to the rat and mouse forms of GPR40. It is a highly potent stimulator of insulin secretion in MIN6 cells with an EC50 comparable to that seen in the aequorin Ca2+-flux assay. It was a potent partial agonist in the calcium flux assay on the GPR40 receptor and potentiated glucose stimulated insulin secretion in vitro and in vivo.|
GPR40 Activator 1
GPR40 Activator 1 is a potent GPR40 activator for treatment of type 2 diabetes.
MEDICA 16 is a selective free fatty acid 1 receptor agonist. It is also an ATP citrate lyase inhibitor. MEDICA 16 shows hypolipidemic and antidiabetogenic effec...
AMG 837 sodium salt is a potent GPR40 agonist with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents. ...
This active molecular is a free fatty acid (FFA) 1 receptor agonist. TUG-469 is more than two hundred fold selective for FFA1 over FFA4. TUG-469 can potential u...
TUG-770 displayed excellent physicochemical and in vitro ADME properties, with good aqueous solubility, good chemical stability, low lipophilicity, and decrease...
This active molecular is a potent GPR40 agonist and it was found to have potent glucose lowering effects during an oral glucose tolerance test in animal models....
TAK-875 is a potent, selective, and orally bioavailable GPR40 agonist, with a pharmacokinetic profile enabling long-acting drug efficacy.
AS 2034178 has been found to be a FFA1/GPR40 agonist and could probably be used against diabetes.