|Description||AMG-747 is a GlyT-1 inhibitor. It has been under investigation to treat various CNS disorders that may be ameliorated by modulation of either inhibitory glycinergic or excitatory glutamatergic neurotransmission. It was used as an antipsychotic drug. It was developed by Amgen and was terminated in Cilnic phase 2.|
|Synonyms||1-Piperazineacetic acid, 4-((R)-phenyl(3-(trifluoromethyl)phenyl)methyl)-;2-[4-[(R)-phenyl-[3-(trifluoromethyl)phenyl]methyl]piperazin-1-yl]acetic acid;AMG747|
|Solubility||10 mM in DMSO|
|Application||AMG-747 was used as an antipsychotic drug.|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
|Melting Point||455.3±45.0 °C | Condition: Press: 760 Torr|
|Density||1.276±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr|
|Current Developer||AMG-747 was developed by Amgen and was terminated in Cilnic phase 2.|
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