AMG-747 - CAS 1000690-85-6
Catalog number: 1000690-85-6
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C20H21F3N2O2
Molecular Weight:
378.39
COA:
Inquire
Targets:
Others
Description:
AMG-747 is a GlyT-1 inhibitor. It has been under investigation to treat various CNS disorders that may be ameliorated by modulation of either inhibitory glycinergic or excitatory glutamatergic neurotransmission. It was used as an antipsychotic drug. It was developed by Amgen and was terminated in Cilnic phase 2.
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Purity:
>98 %
Appearance:
Solid powder
Synonyms:
1-Piperazineacetic acid, 4-((R)-phenyl(3-(trifluoromethyl)phenyl)methyl)-;2-[4-[(R)-phenyl-[3-(trifluoromethyl)phenyl]methyl]piperazin-1-yl]acetic acid;AMG747
Solubility:
10 mM in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
AMG-747 was used as an antipsychotic drug.
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
Melting Point:
455.3±45.0 °C | Condition: Press: 760 Torr
Density:
1.276±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
InChIKey:
MDLQJNCGZVDZFV-LJQANCHMSA-N
InChI:
InChI=1S/C20H21F3N2O2/c21-20(22,23)17-8-4-7-16(13-17)19(15-5-2-1-3-6-15)25-11-9-24(10-12-25)14-18(26)27/h1-8,13,19H,9-12,14H2,(H,26,27)/t19-/m1/s1
Canonical SMILES:
C1CN(CCN1CC(=O)O)C(C2=CC=CC=C2)C3=CC(=CC=C3)C(F)(F)F
Current Developer:
AMG-747 was developed by Amgen and was terminated in Cilnic phase 2.
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