AMG-747 - CAS 1000690-85-6
Catalog number: 1000690-85-6
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C20H21F3N2O2
Molecular Weight:
378.39
COA:
Inquire
Targets:
Others
Description:
AMG-747 is a GlyT-1 inhibitor. It has been under investigation to treat various CNS disorders that may be ameliorated by modulation of either inhibitory glycinergic or excitatory glutamatergic neurotransmission. It was used as an antipsychotic drug. It was developed by Amgen and was terminated in Cilnic phase 2.
Purity:
>98 %
Appearance:
Solid powder
Synonyms:
1-Piperazineacetic acid, 4-((R)-phenyl(3-(trifluoromethyl)phenyl)methyl)-;2-[4-[(R)-phenyl-[3-(trifluoromethyl)phenyl]methyl]piperazin-1-yl]acetic acid;AMG747
Solubility:
10 mM in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
AMG-747 was used as an antipsychotic drug.
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
Melting Point:
455.3±45.0 °C | Condition: Press: 760 Torr
Density:
1.276±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
InChIKey:
MDLQJNCGZVDZFV-LJQANCHMSA-N
InChI:
InChI=1S/C20H21F3N2O2/c21-20(22,23)17-8-4-7-16(13-17)19(15-5-2-1-3-6-15)25-11-9-24(10-12-25)14-18(26)27/h1-8,13,19H,9-12,14H2,(H,26,27)/t19-/m1/s1
Canonical SMILES:
C1CN(CCN1CC(=O)O)C(C2=CC=CC=C2)C3=CC(=CC=C3)C(F)(F)F
Current Developer:
AMG-747 was developed by Amgen and was terminated in Cilnic phase 2.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products


CAS 420126-30-3 Antitumor Compound 1

Antitumor Compound 1
(CAS: 420126-30-3)

Antitumor Compound 1 is a potent compound which comprises a new imidazopyridine having excellent antitumor activity as an active ingredient.

CAS 21738-42-1 Oxamniquine

Oxamniquine
(CAS: 21738-42-1)

Oxamniquine, with schistosomicidal activity, is an antischistosomal drug used in the treatment of Schistosoma mansoni infection.

CAS 50-56-6 Oxytocin

Oxytocin
(CAS: 50-56-6)

Oxytocin is a mammalian neurohypophysial hormone. It plays an important role in the neuroanatomy of intimacy, specifically in sexual reproduction of both sexes,...

CB 966
(CAS: 128312-71-0)

CB 966 is a novel analogues of 1,25-dihydroxyvitamin D3 and it was found to significantly delay the rejection of allogeneic skin grafts in CBA (H-2k) recipient ...

CAS 130-86-9 Protopine

Protopine
(CAS: 130-86-9)

Protopine, an isoquinoline alkaloid compound, is a Ca2+ channel blocker and could be used in immunoregulation.

CAS 129909-90-6 Amicarbazone

Amicarbazone
(CAS: 129909-90-6)

The phenotypic responses of sensitive plants exposed to amicarbazone include chlorosis, stunted growth, tissue necrosis, and death. Its efficacy as both a folia...

CAS 154978-38-8 BAY-u 9773

BAY-u 9773
(CAS: 154978-38-8)

BAY-u 9773 is a non-selective cysteinyl leukotriene receptor antagonist displaying equal affinity for both CysLT1 and CysLT2 receptors (pKB = 6.8 and 6.5, respe...

CAS 132-60-5 Cinchophen

Cinchophen
(CAS: 132-60-5)

Cinchophen is an analgesic drug that is frequently used to treat gout.

Quick Inquiry

Verification code

Featured Items