|Description||AMG-747 is a GlyT-1 inhibitor. It has been under investigation to treat various CNS disorders that may be ameliorated by modulation of either inhibitory glycinergic or excitatory glutamatergic neurotransmission. It was used as an antipsychotic drug. It was developed by Amgen and was terminated in Cilnic phase 2.|
|Synonyms||1-Piperazineacetic acid, 4-((R)-phenyl(3-(trifluoromethyl)phenyl)methyl)-;2-[4-[(R)-phenyl-[3-(trifluoromethyl)phenyl]methyl]piperazin-1-yl]acetic acid;AMG747|
|Solubility||10 mM in DMSO|
|Application||AMG-747 was used as an antipsychotic drug.|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
|Melting Point||455.3±45.0 °C | Condition: Press: 760 Torr|
|Density||1.276±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr|
|Current Developer||AMG-747 was developed by Amgen and was terminated in Cilnic phase 2.|
Insect tachykinin-related peptide (TRP) isolated from Locusta migratoria. Exhibits sequence homology with vertebrate tachykinins.
Pipazetate, as a cough suppressant, is a non-narcotic oral antitussive agent acting centrally on the medullary cough center.
CP-394531 is an effective Glucocorticoid receptor agonist and probably has steroid-like anti-inflammatory properties with anti-GR and anti-obesity activity in a...
Peptide5 is a mimetic peptide of Connexin 43 (Cx43), which is the most ubiquitously expressed type of Cx in the skin. It reduces swelling, astrogliosis, neuroin...
pGlu-Pro-Arg-MNA is a peptide compound that has potential biology activity in many areas.
Diphenyleneiodonium chloride has been found to be a GPR3 agonist and also exhibit inhibition against NO synthase, NADG reductase and NADPH oxidase.
TPT-260 2HCl is a thiophene thiourea derivative that acts as a chaperone to stabilize the retromer complex against thermal denaturation.
Ligustilide not only has an active dilatory effect on myometrium but also an effective role in reducing the neurogenic and inflammatory pain, thus having the po...
Potent and competitive kynurenine 3-hydroxylase inhibitor (IC50 = 37 nM). Shows antidystonic, anticonvulsant and neuroprotective effects in vivo. Blood-brain ba...
Arg-Gly-Glu-Ser, a RGD-related peptide, is a control for the RGDS ihibitory activity on fibrinogen binding to activated platelets.
Wilforine, a sesquiterpene pyridine alkaloid, is effective in treating idiopathic pulmonary fibrosis.
NBMPR is an equilibrative nucleoside transporter (ENT) 1 inhibitor.
AT-4930 is a bio-active molecular, but detailed information has not been published yet.
Nortriptyline is a second-generation antidepressant originated by Lilly. It is a non-selective monoamine reuptake inhibitor. Nortriptyline can be used for the t...
Lonidamine is a derivative of indazole-3-carboxylic acid, which for a long time, has been known to inhibit aerobic glycolysis in cancer cells. It seems to enhan...
1,8-Dihydroxyanthraquinone, an anthraquinone derivative, could be widely used as antioxidant, dye intermediate and a raw material to synthesise sorts of product...
Rafigrelide is a platelet aggregation inhibitor, which plays a central role in atherothrombotic events. It could prolonge clot formation time and reduce clot st...
Mice treated with vehicle showed significantly enlarged tumors, whereas mice treated with YL-109 showed attenuated tumor growth using MCF-7 cells. Interestingly...
Bitoscanate is an organic chemical compound used in the treatment of hookworms.
NVP-231 is a potent, specific, and reversible CerK inhibitor that competitively inhibits binding of ceramide to CerK. NVP-231 is active in the low nanomolar ran...