AMG 548 - CAS 864249-60-5
Catalog number:
864249-60-5
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C29H27N5O
Molecular Weight:
461.56
COA:
Inquire
Targets:
p38 MAPK
Description:
AMG-548 is a selective p38α inhibitor with Ki value of 0.5nM. It displays >1000-fold selectivity against 36 other kinases, and it can inhibit whole blood LPS-stimulated TNFα. In Sep 2008, Preclinical for Rheumatoid arthritis in USA was discontinued.
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Purity:
98%
Appearance:
Powder
Synonyms:
2-[[(2S)-2-Amino-3-phenylpropyl]amino]-3-methyl-5-(2-naphthalenyl)-6-(4-pyridinyl)-4(3H)-pyrimidinone
Solubility:
Soluble in DMSO
Storage:
-20℃ Freezer
MSDS:
Inquire
Application:
Inflammation; Rheumatoid arthritis
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
InChIKey:
RQVKVJIRFKVPBF-VWLOTQADSA-N
InChI:
1S/C29H27N5O/c1-34-28(35)26(24-12-11-21-9-5-6-10-23(21)18-24)27(22-13-15-31-16-14-22)33-29(34)32-19-25(30)17-20-7-3-2-4-8-20/h2-16,18,25H,17,19,30H2,1H3,(H,32,33)/t25-/m0/s1
Canonical SMILES:
Cn1c(=O)c(c(nc1NC[C@H](Cc2ccccc2)N)c3ccncc3)c4ccc5ccccc5c4
Current Developer:
Originator Amgen
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

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