|Description||AMG-47a is a potent inhibitor of Lck and T cell proliferation. It has anti-inflammatory activity (ED50 = 11 mg/kg) in the anti-CD3 induced production of IL-2 in mice. It displays subnanomolar inhibition against Lck, and low inhibition against other hard to inhibit kinases in several other in vitro assays. It effectively inhibits the JNK family of kinases including TYK2 at ~ 1.2 μM but well under 10 μM. It selectively reduced the levels of EGFP-KRASG12V protein but did not affect EGFP protein in cells.|
|Solubility||10 mM in DMSO|
|Application||AMG-47a has anti-inflammatory activity.|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
|Quantity||Grams to Kilograms|
|Density||1.324±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr|
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