|Description||AMG-126737 is a potent inhibitor of human lung mast cell tryptase (Ki = 90 nM), with greater than 10- to 200-fold selectivity versus other serine proteases.|
|Synonyms||3-[[4-[5-[4-[[(3-carbamimidoylphenyl)sulfonylamino]methyl]phenoxy]pentoxy]phenyl]methylsulfamoyl]benzenecarboximidamide; 1,5-bis-(4-((3-carbamimidoyl-benzenesulfonylamino)-methyl)-phenoxy)-pentane; AMG 126737; AMG-126737|
GGTI 298 (trifluoroacetate salt)
GGTI-298 is a selective geranylgeranyltransferase type I inhibitor that displays little effect on other prenylation enzymes such as farnesyltransferase. GGTI-29...
Dezaguanine is a new antipurine antimetabolite with activity against transplantable rodent leukemias.
UPF-648 sodium salt
UPF-648 sodium salt is a potent kynurenine 3-monooxygenase (KMO) inhibitor; exhibits highly active at 1 uM (81 ± 10% KMO inhibition); ineffective at bloc...
Etimizol was shown to relieve amnesia effectively in the origin of which there is the hypoxic component (hypobaric hypoxia, actinomycin D, mechanical injury of ...
LY 135305 is a bio-active molecular under the development of Eli Lilly. It can inhibit spontaneous lung metastasis in a dose-dependent manner.
Fenoprofen calcium hydrate
Fenoprofen calcium hydrate is a non-steroidal anti-inflammatory drug (NSAID).
Ginsenoside Rg1, the predominant ginsenoside in the rhizome,shows no hemolytic nor cytotoxic activities.It acts as a weak phytoestrogen, presumably by binding a...
10-Hydroxycamptothecin inhibits the growth of BT-20 and MDA-231 cell with IC50 of 34.3 nM and 7.27 nM, respectively, more potently than camptothecin (CPT) with ...
Buspirone is a serotonergic (5HT(1A) receptor agonist) anxiolytic drug with some D(2) dopaminergic effect, used for anxiety disorders.
Guanidine HCl, the crystalline compound of strong alkalinity formed by the oxidation of guanine, is a normal product of protein metabolism and a protein denatur...
This active molecular is a cAMP/PKA/CREB pathway activator promoting osteogenic differentiation of human bone marrow derived MSCs in vitro, and it also increase...
CP 81282 shows human renin and endothiapepsin inhibitory efficacy, but no detailed data has been published yet.
Heptaminol Hydrochloride is an amino alcohol which is classified as a vasoconstrictor used in the treatment of low blood pressure, particularly orthostatic hypo...
Trimipramine is a tricyclic antidepressant. It is serotonin and norepinephrine transport inhibitor with antipsychotic and sedative properties.
HI TOPK 032
HI TOPK 032 is a novel TOPK inhibitor as a T-LAK-cell-originated protein kinase (TOPK) inhibitor, blocking phosphorylation of the substrate histone H2AX with a...
A chelator that could replace disferrioxamine. It is orally and parenterally effective in the removal of iron in vivo from rabbits and mice and also from transf...
NAI-N3 is a novel RNA acylation reagent that enables RNA purification.
Codergocrine mesilate is a mixture of the methanesulfonate salts of three dihydrogenated ergot alkaloids. It binds with high affinity to the GABAA receptor Cl- ...
ECMS is a useful protective group in antibody drug conjugates as a ADCs Linker.
LY 249933 is a bio-active molecular under the development of Eli Lilly. It has positive inotropic activity as a cardioselective 1,4-dihydropyridine compound.