|Targets||CXCR | HIV|
|Description||AMD3465 is a potent and highly selective monomacrocyclic CXCR4 antagonist (IC50= 0.75 nM). It potently inhibits HIV cell entry in vitro and causes leukocytosis and mobilizes haematopoietic stem cells in vivo. It dose dependently inhibits eosinophil recruitment during type-2 granuloma formation and interferes with primary and secondary T-cell activation events in lymphoid tissue.|
|Brife Description||A potent and highly selective monomacrocyclic CXCR4 antagonist (IC50= 0.75 nM)|
|Related CAS||185991-24-6 (free base)|
|Appearance||Pale Yellow Solid|
|Solubility||Soluble to 50 mM in water and to 25 mM in DMSO|
|Storage||Store in a cool and dry place (or refer to the Certificate of Analysis).|
AMD3465 is a potent and highly selective monomacrocyclic CXCR4 antagonist (IC50= 0.75 nM). It potently inhibits HIV cell entry in vitro and causes leukocytosis ...
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