AMD 3465 - CAS 185991-24-6
Catalog number:
185991-24-6
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C24H38N6
Molecular Weight:
410.60
COA:
Inquire
Targets:
CXCR
Description:
AMD 3465,a N-pyridinylmethylene monocyclam, is a selective antagonist of CXCL12/CXCR4-mediated interactions including ligand binding and receptor activation. With its enhanced potency against the CXCR4 receptor compared with plerixafor, AMD 3465 has been
Publictions citing BOC Sciences Products
  • >> More
Appearance:
Light-pink solid
Synonyms:
N-(pyridin-2-ylmethyl)-1-[4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methanamine;hexahydrobromide AMD 3465 hexahydrobromide 185991-07-5 185991-24-6 AMD3465 6 HBr C24H38N6.6BrH AMD3465 GENZ-644494 N-(1,4,8,11- tetraazacyclotetradecanyl-1,4-phenylen
Solubility:
Soluble to 93.2 mg/ml in water, and to 34.0 mg/ml in DMSO
Storage:
Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -73℃ for long term (months to years).
MSDS:
Inquire
Shelf Life:
2 years
Boiling Point:
571.3±50.0 °C | Condition: Press: 760 Torr
Melting Point:
200-205 °C (decomp)
Density:
1.022±0.06 g/cm3
InChIKey:
ARHBIBDGWDRBJH-UHFFFAOYSA-N
InChI:
1S/C24H38N6.6BrH/c1-2-13-29-24(5-1)20-28-19-22-6-8-23(9-7-22)21-30-17-4-12-26-15-14-25-10-3-11-27-16-18-30;;;;;;/h1-2,5-9,13,25-28H,3-4,10-12,14-21H2;6*1H
Canonical SMILES:
C1CNCCNCCCN(CCNC1)CC2=CC=C(C=C2)CNCC3=CC=CC=N3.Br.Br.Br.Br.Br.Br
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related CXCR Products


CAS 855527-92-3 NBI-74330

NBI-74330
(CAS: 855527-92-3)

A small molecule antagonist for CXCR3

CAS 906805-42-3 SCH 546738

SCH 546738
(CAS: 906805-42-3)

A novel, potent and non-competitive small molecule CXCR3 antagonist with Ki of 0.4 nM

CAS 880549-30-4 AMD-070 hydrochloride

AMD-070 hydrochloride
(CAS: 880549-30-4)

Potent and selective antagonist of CXCR4 (with an IC50 value of 13 nM in a CXCR4 125I-SDF inhibition binding assay)

FC 131
(CAS: 606968-52-9)

CXCR4 antagonist

Navarixin
(CAS: 862464-58-2)

Navarixin is a potent CXC chemokine receptor 2 (CXCR2) antagonist. It can be used for the treatment of Asthma and Chronic obstructive pulmonary disease. In Dec ...

CAS 897657-95-3 MSX-122

MSX-122
(CAS: 897657-95-3)

A novel small molecule and partial CXCR4 antagonist

SB 332235
(CAS: 276702-15-9)

Potent CXCR2 antagonist

CAS 182498-32-4 SB225002

SB225002
(CAS: 182498-32-4)

Potent and selective non-peptide inhibitor of CXCR2 with IC50 of 22 nM

CAS 1986-81-8 Nicotinamide N-oxide

Nicotinamide N-oxide
(CAS: 1986-81-8)

Nicotinamide N-oxide, a metabolite of Nicotinamide, is a potent, and selective antagonist of the CXCR2 receptor and used in studies of mechanisms of niacin-rela...

NVP CXCR2 20
(CAS: 1029521-30-9)

Potent and selective CXCR2 antagonist

CAS 211096-49-0 SB 265610

SB 265610
(CAS: 211096-49-0)

Potent CXCR2 antagonist

CAS 558447-26-0 AMD-070

AMD-070
(CAS: 558447-26-0)

Potent and selective antagonist of CXCR4 (with an IC50 value of 13 nM in a CXCR4 125I-SDF inhibition binding assay)

CAS 266359-83-5 Reparixin

Reparixin
(CAS: 266359-83-5)

An inhibitor of CXCL8 receptor, also inhibit CXCR1 and CXCR2 activation

CAS 55778-02-4 WZ 811

WZ 811
(CAS: 55778-02-4)

Potent CXCR2 antagonist

ATI 2341
(CAS: 1337878-62-2)

CXCR4 allosteric agonist

VUF 11222
(CAS: 1414376-84-3)

High affinity non-peptide CXCR3 agonist (pKi = 7.2)

AMD 3465
(CAS: 185991-24-6)

AMD 3465,a N-pyridinylmethylene monocyclam, is a selective antagonist of CXCL12/CXCR4-mediated interactions including ligand binding and receptor activation. Wi...

(±)-NBI 74330
(CAS: 473722-68-8)

Potent and selective CXCR3 antagonist

CAS 473727-83-2 SCH 527123

SCH 527123
(CAS: 473727-83-2)

A potent antagonist of both CXCR1 and CXCR2 with IC50 of 42 nM and 3 nM, respectively.

CAS 155148-31-5 AMD 3100 octahydrochloride

AMD 3100 octahydrochloride
(CAS: 155148-31-5)

Highly selective CXCR4 chemokine receptor antagonist (IC50 values are 0.02 - 0.13 and > 25 μM for CXCR4 and all other chemokine receptors respectively)

Quick Inquiry

Verification code

Featured Items