AMD 3100 octahydrochloride - CAS 155148-31-5
Catalog number: 155148-31-5
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C28H54N8.8HCl
Molecular Weight:
794.48
COA:
Inquire
Targets:
CXCR
Description:
Highly selective CXCR4 chemokine receptor antagonist (IC50 values are 0.02 - 0.13 and > 25 μM for CXCR4 and all other chemokine receptors respectively)
Brife Description:
Highly selective CXCR4 chemokine receptor antagonist (IC50 values are 0.02 - 0.13 and > 25 μM for CXCR4 and all other chemokine receptors respectively)
Appearance:
White solid
Synonyms:
1,1'-(1,4-Phenylenebis(methylene))bis-1,4,8,11-tetraazacyclotetradecane octahydrochloride; AMD 3100; AMD 3329; AMD-3100; AMD-3329; AMD3100; bicyclam; JM 3100;
Solubility:
Soluble to 100 mM in water
Storage:
Desiccate at -20°C
MSDS:
Inquire
Quality Standard:
In-house
Quantity:
Grams-Kilos
Melting Point:
188 - 193°C (dec.)
InChIKey:
UEUPDYPUTTUXLJ-UHFFFAOYSA-N
InChI:
1S/C28H54N8.8ClH/c1-9-29-15-17-31-13-3-21-35(23-19-33-11-1)25-27-5-7-28(8-6-27)26-36-22-4-14-32-18-16-30-10-2-12-34-20-24-36;;;;;;;;/h5-8,29-34H,1-4,9-26H2;8*1H
Canonical SMILES:
C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1
1.[⁹⁹mTc]O₂-AMD3100 as a SPECT tracer for CXCR4 receptor imaging.
Hartimath SV1, Domanska UM, Walenkamp AM, Rudi A J O D, de Vries EF. Nucl Med Biol. 2013 May;40(4):507-17. doi: 10.1016/j.nucmedbio.2013.02.003. Epub 2013 Mar 20.
PURPOSE: CXCR4 plays an important role in HIV infection, tumor progression, neurogenesis, and inflammation. In-vivo imaging of CXCR4 could provide more insight in the role of this receptor in health and disease. The aim of this study was to investigate [(99m)Tc]O₂-AMD3100 as a potential SPECT tracer for imaging of CXCR4.
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Chemical Structure

CAS 155148-31-5 AMD 3100 octahydrochloride

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