Amcinonide - CAS 51022-69-6
Catalog number: 51022-69-6
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
Molecular Weight:
Glucocorticoid Receptor
Amcinonide is a corticosteroid (IC50=3.38 nM) used as anti-inflammatory and antipruritic agents.
White to Off-White Solid
Soluble in DMSO
Store at -20 °C
Quality Standard:
Enterprise Standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Melting Point:
>216 °C
1.33 g/cm3
Canonical SMILES:
Current Developer:
Teva Canada Limited
1.Allergic contact dermatitis to topical drugs--epidemiological risk assessment.
de Pádua CA1, Schnuch A, Nink K, Pfahlberg A, Uter W. Pharmacoepidemiol Drug Saf. 2008 Aug;17(8):813-21. doi: 10.1002/pds.1588.
PURPOSE: Estimation of the population-based relative incidence (RI) of contact sensitization to a set of topical drug allergens (cases/100,000 defined daily doses (DDDs) per year) (1995-2004) and comparison of the RI for drugs with a similar therapeutic scope.
2.Patch testing with serial dilutions of budesonide, its R and S diastereomers, and potentially cross-reacting substances.
Isaksson M1, Bruze M, Lepoittevin JP, Goossens A. Am J Contact Dermat. 2001 Sep;12(3):170-6.
BACKGROUND: Budesonide, a marker for corticosteroid allergy, is a 1:1 mixture of 2 diastereomers, the R and S, present in all commercial formulations. Budesonide is said to cross-react with group B substances through the R and S diastereomer and some group D substances only through the S diastereomer.
3.Selective corticosteroid injection into the extensor pollicis brevis tenosynovium for de Quervain's disease.
Sakai N1. Orthopedics. 2002 Jan;25(1):68-70.
Selective corticosteroid injection into the extensor pollicis brevis tenosynovium was performed in 50 patients (7 men and 43 women; 53 hands) with de Quervain's disease. Mean patient age was 32.4 years and mean follow-up was 4.1 years. Before selective injection into the extensor pollicis brevis tenosynovium, the extensor pollicis brevis tendon was palpated at the distal ulnar side of the first compartment, with dorsal and volar flexion of the first metacarpophalangeal joint. A 27-gauge needle was placed along the extensor pollicis brevis tendon and into the distal entrance of the extensor pollicis brevis tenosynovium selectively, and 10 mg of 40 mg/mL triamcinolone acetonide and 0.25 mL of 1% xylocaine were combined and injected. Forty-six hands had relief of pain following a single injection. Six hands required a second injection and 1 hand required a third injection. Ultimately, all 53 hands had satisfactory results by selective extensor pollicis brevis injection alone, and no patients required surgical treatment.
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CAS 51022-69-6 Amcinonide

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