Amantadine Hydrochloride - CAS 665-66-7
Catalog number: 665-66-7
Category: Inhibitor
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Molecular Formula:
Molecular Weight:
Influenza Virus
Amantadine Hydrochloride is a NMDA-receptor antagonist acts as an antiviral and an antiparkinsonian drug.
White Solid
1-Adamantanamine hydrochloride; adamantan-1-amine;hydrochloride
Soluble in DMSO
Store at -20 °C
Dopaminergic agent. Antiviral.
Quality Standard:
Enterprise Standard/USP/EP
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Melting Point:
360 °C
Canonical SMILES:
Current Developer:
Adamas Pharmaceuticals
1.Does amantadine induce acute psychosis? A case report and literature review.
Xu WJ1, Wei N1, Xu Y1, Hu SH1. Neuropsychiatr Dis Treat. 2016 Apr 6;12:781-3. doi: 10.2147/NDT.S101569. eCollection 2016.
BACKGROUND: Over-the-counter cold medicines, which contain amantadine, are widely used in the People's Republic of China. Clinicians are familiar with the psychosis caused by long-term treatment with amantadine, especially in elderly patients; however, early-onset psychotic complications among healthy young individuals have rarely been reported.
2.Resolution of periodic alternating nystagmus with amantadine.
Lee SH1, Lee SY1, Choi SM1, Kim BC1, Kim MK1, Kim JS2. J Neurol Sci. 2016 May 15;364:65-7. doi: 10.1016/j.jns.2016.03.014. Epub 2016 Mar 10.
3.Involvement of a Proton-Coupled Organic Cation Antiporter in the Blood-Brain Barrier Transport of Amantadine.
Suzuki T1, Aoyama T2, Suzuki N1, Kobayashi M3, Fukami T4, Matsumoto Y2, Tomono K1. Biopharm Drug Dispos. 2016 May 4. doi: 10.1002/bdd.2014. [Epub ahead of print]
The blood-to-brain transport of amantadine, a weak N-methyl-D-aspartate (NMDA) antagonist, has been previously shown to participate in the cationic drug-sensitive transport system across the mouse blood-brain barrier (BBB). The purpose of the present study was to characterize the influx transport system by means of both an in situ mouse brain perfusion technique and in vitro studies using rat immortalized brain capillary endothelial cells (GPNT). The observed concentration-dependent initial uptake rate of [3 H]amantadine suggested the involvement of a carrier-mediated transport mechanism. The normal uptake at the physiological pH 7.4 was decreased by 72.9% in acidic perfusate, while it was increased by 35.3% in alkaline perfusate. These results suggest that the pH-dependent transport is regulated by utilizing an oppositely directed proton gradient as a driving force. In addition, the [3 H]amantadine uptake was moderately inhibited by the adamantane structural analogs (rimantadine and memantine) and other cationic-drugs (pyrilamine, clonidine, nicotine, etc.
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CAS 665-66-7 Amantadine Hydrochloride

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