AM4668 - CAS 1011531-27-3
Catalog number:
1011531-27-3
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C24H19F3N2O4S
Molecular Weight:
488.48
COA:
Inquire
Targets:
GPR40
Description:
AM4668 is a potent and selective G-protein coupled receptor 40(GPR40) agonist with EC50 value of 3.6 nM in an IP3 assay in GPR40 transfected A9 cells. It is more potent than AMG 837 and possesses excellent pharmacokinetic properties across species. It could reduce the plasma glucose levels in an OGTT study in human GPR40 knock-in mice. It inhibits insulin secretion from isolated pancreatic islets.
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Purity:
>98 %
Appearance:
Solid powder
Synonyms:
AM-4668; ;(S)-3-(isoxazol-3-yl)-3-(4-((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)methoxy)phenyl)propanoic acid;(βS)-β-[4-[[4-Methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methoxy]phenyl)-3-isoxazolepropanoic acid
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
AM4668 could reduce the plasma glucose levels in an OGTT study. It inhibits insulin secretion from isolated pancreatic islets.
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
Boiling Point:
633.4±65.0 °C | Condition: Press: 760 Torr
Density:
1.373±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
InChI:
InChI=1S/C24H19F3N2O4S/c1-14-21(34-23(28-14)16-2-6-17(7-3-16)24(25,26)27)13-32-18-8-4-15(5-9-18)19(12-22(30)31)20-10-11-33-29-20/h2-11,19H,12-13H2,1H3,(H,30,31)/t19-/m0/s1
Canonical SMILES:
O=C(O)C[C@H](C1=NOC=C1)C2=CC=C(OCC3=C(C)N=C(C4=CC=C(C(F)(F)F)C=C4)S3)C=C2
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

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