|Synonyms||AM095 AM-095; AM 095.|
|Current Developer||Amira Pharmaceuticals|
Ki16425 is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3 with Ki of 0.34 μM, 6.5 μM and 0.93 μM, respectively, shows no activity at LPA...
LPA2 antagonist 1
LPA2 antagonist 1 could block the Erk activation regulated by LPA(2) and proliferation of HCT-116 cells as a selective inhibitor of LPA2 protein. IC50: 17 nM (i...
AM966, a LPA1 receptor antagonist, has been found to restrain lung fibrosis in mouse model. IC50: 17 nM.
Siponimod is a next-generation S1P receptor modulator, selective for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, exhibits >1000-fold selectivity o...
AM095 (Free Acid)
AM095, an effective LPA1 receptor antagonist, has been found to decrease dermal fibrosis caused by attenuates bleomycin. IC50: 0.98 uM and 0.73 uM for human and...
CYM-5541, also called as ML249, is a selective sphingosine-1-phosphate receptor 3 (S1P3) allosteric agonist (EC50 = 72-132 nM) that less effectively activates S...
PF429242, is a reversible, competitive and cell permeable SKI-1/S1P inhibitor (IC50= 175 nM) and demonstrates a very potent and virus-specific antiviral effect ...
Fingolimod (FTY720) is a S1P antagonist with IC50 of 0.033 nM.
The modulator of sphingosine-1-phosphate receptor
S1P1 Agonist III
S1P1 Agonist III, a S1P1 agonist, has been found to induce the lymphocyte counts' reduction in circulating blood and have potentials in study of autoimmune dise...
Fingolimod, a derivative of the fungal metabolite myriocin, is a antagonist of S1P (IC50 of 0.033 nM) which is an extracellular lipid mediator.
ONO-7300243 is a novel, potent LPA1 (Lysophosphatidic Acid Receptor) antagonist (IC50= 160 nM). In vitro ONO-7300243 showed good membrane permeability and good ...