|Synonyms||AM095 AM-095; AM 095.|
|Current Developer||Amira Pharmaceuticals|
CYM-5541, also called as ML249, is a selective sphingosine-1-phosphate receptor 3 (S1P3) allosteric agonist (EC50 = 72-132 nM) that less effectively activates S...
Ex 26 is a potent and selective S1P1 receptor antagonist (IC50 = 0.93 nM) with > 3,000-fold selectivity over S1P2, S1P3, S1P4 and S1P5. It causes lymphocyte seq...
S1P1 Agonist III
S1P1 Agonist III, a S1P1 agonist, has been found to induce the lymphocyte counts' reduction in circulating blood and have potentials in study of autoimmune dise...
Ki16425 is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3 with Ki of 0.34 μM, 6.5 μM and 0.93 μM, respectively, shows no activity at LPA...
1-Oleoyl lysophosphatidic acid sodium sa
1-Oleoyl lysophosphatidic acid sodium salt is lysophospholipid receptor (LPA1 and LPA2) agonist. It can inhibit differentiation of neural stem cells into neuron...
H2L5186303 is a potent and selective lysophosphatidic acid 2 (LPA2) receptor antagonist (IC50 = 8.9, 1230 and 27354 nM for LPA2, LPA3 and LPA1 receptors respect...
Sphingosine-1-phosphate is an endogenous second messenger that inhibits cell proliferation and motility, and Ca2+ mobilization to prevent tumor cell metastasis....
Siponimod is a next-generation S1P receptor modulator, selective for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, exhibits >1000-fold selectivity o...
TC LPA5 4
TC LPA5 4 is a LPA5 receptor antagonist (IC50 = 0.8 μM in LPA5-RH7777 cells), displaying selectivity for LPA5 against 80 other screened targets. TC LPA5 4 was s...
ONO-7300243 is a novel, potent LPA1 (Lysophosphatidic Acid Receptor) antagonist (IC50= 160 nM). In vitro ONO-7300243 showed good membrane permeability and good ...
PF429242, is a reversible, competitive and cell permeable SKI-1/S1P inhibitor (IC50= 175 nM) and demonstrates a very potent and virus-specific antiviral effect ...
AM095 (Free Acid)
AM095, an effective LPA1 receptor antagonist, has been found to decrease dermal fibrosis caused by attenuates bleomycin. IC50: 0.98 uM and 0.73 uM for human and...
Ro 6842262 is a potent LPA1 antagonist (IC50 = 25 nM) with >1,200-fold selectivity for LPA1 over LPA3.
Fingolimod (FTY720) is a S1P antagonist with IC50 of 0.033 nM.
Fingolimod, a derivative of the fungal metabolite myriocin, is a antagonist of S1P (IC50 of 0.033 nM) which is an extracellular lipid mediator.
W146 is a potent and selective sphingosine-1-phosphate receptor (S1P1) antagonist (Ki = 18 nM) with no effect at S1P2, S1P3 or S1P5. W146 potentiates capillary ...
The modulator of sphingosine-1-phosphate receptor
H2L 5765834 is an antagonist of the lysophosphatidic acid receptors LPA1, LPA5 and LPA3 (IC50 = 94, 463 and 752 nM, respectively). H2L 5765834 may be used for t...
LPA2 antagonist 1
LPA2 antagonist 1 could block the Erk activation regulated by LPA(2) and proliferation of HCT-116 cells as a selective inhibitor of LPA2 protein. IC50: 17 nM (i...