|Targets||NMDA Receptor | Sodium Channel|
|Description||AM-36 is a potent blocker of batrachotoxinin (BTX)-sensitive Na+ channel binding in rat brain homogenates with an IC50 of 0.28 microM. As a unique neuroprotective agent with anti-oxidant activity, in neuronal cell cultures, AM-36 inhibited toxicity induced by N-methyl-D-aspartate (NMDA) and the sodium channel opener veratridine and, in addition, inhibited veratridine-induced apoptosis.|
|Synonyms||2,6-ditert-butyl-4-[[4-[2-(4-chlorophenyl)-2-hydroxyethyl]piperazin-1-yl]methyl]phenol; AM-36; AM 36; AM36; UNII-08OBY024NY; SCHEMBL12311270; CNSB 002; CNSB-002; CNSB002|
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The meleate salt form of (±)-1-(1,2-Diphenylethyl)piperidine, which has been found to be a high affinity antagonist at the ion channel on the NMDA receptor.