Alvespimycin HCl - CAS 467214-21-7
Catalog number:
467214-21-7
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C32H48N4O8•HCl
Molecular Weight:
653.21
COA:
Inquire
Targets:
Hsp90 | HSP
Description:
Alvespimycin hydrochloride is the hydrochloride salt of alvespimycin, an analogue of the antineoplastic benzoquinone antibiotic geldanamycin. Alvespimycin binds to Hsp90, a chaperone protein that aids in the assembly, maturation and folding of proteins. Subsequently, the function of Hsp90 is inhibited, leading to the degradation and depletion of its client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction.
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Brife Description:
17-DMAG (Alvespimycin) HCl is a potent Hsp90 inhibitor with IC50 of 62 nM in a cell-free assay.
Purity:
>98%
Appearance:
Solid powder
Synonyms:
17-DMAG HCl; NSC 707545; BMS 826476 HCl; KOS 1022.
Solubility:
DMSO: >25 mg/ML
Storage:
3 years -20oC powder, 6 months-80oC in solvent.
MSDS:
Inquire
Quality Standard:
In-house
Quantity:
Grams-Kilos
InChIKey:
DFSYBWLNYPEFJK-IHLRWNDRSA-N
InChI:
InChI=1S/C32H48N4O8.ClH/c1-18-14-22-27(34-12-13-36(5)6)24(37)17-23(29(22)39)35-31(40)19(2)10-9-11-25(42-7)30(44-32(33)41)21(4)16-20(3)28(38)26(15-18)43-8;/h9-11,16-18,20,25-26,28,30,34,38H,12-15H2,1-8H3,(H2,33,41)(H,35,40);1H/b11-9-,19-10+,21-16+;/t18-,20+,25+,26+,28-,30+;/m1./s1
Canonical SMILES:
CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCN(C)C)C)OC)OC(=O)N)C)C)O)OC.Cl
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

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Chemical Structure

CAS 467214-21-7 Alvespimycin HCl

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