|Targets||Hsp90 | HSP|
|Description||Alvespimycin hydrochloride is the hydrochloride salt of alvespimycin, an analogue of the antineoplastic benzoquinone antibiotic geldanamycin. Alvespimycin binds to Hsp90, a chaperone protein that aids in the assembly, maturation and folding of proteins. Subsequently, the function of Hsp90 is inhibited, leading to the degradation and depletion of its client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction.|
|Brife Description||17-DMAG (Alvespimycin) HCl is a potent Hsp90 inhibitor with IC50 of 62 nM in a cell-free assay.|
|Synonyms||17-DMAG HCl; NSC 707545; BMS 826476 HCl; KOS 1022.|
|Solubility||DMSO: >25 mg/ML|
|Storage||3 years -20oC powder, 6 months-80oC in solvent.|
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