Alvespimycin HCl - CAS 467214-21-7
Catalog number: 467214-21-7
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C32H48N4O8•HCl
Molecular Weight:
653.21
COA:
Inquire
Targets:
Hsp90 | HSP
Description:
Alvespimycin hydrochloride is the hydrochloride salt of alvespimycin, an analogue of the antineoplastic benzoquinone antibiotic geldanamycin. Alvespimycin binds to Hsp90, a chaperone protein that aids in the assembly, maturation and folding of proteins. Subsequently, the function of Hsp90 is inhibited, leading to the degradation and depletion of its client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction.
Publictions citing BOC Sciences Products
  • >> More
Brife Description:
17-DMAG (Alvespimycin) HCl is a potent Hsp90 inhibitor with IC50 of 62 nM in a cell-free assay.
Purity:
>98%
Appearance:
Solid powder
Synonyms:
17-DMAG HCl; NSC 707545; BMS 826476 HCl; KOS 1022.
Solubility:
DMSO: >25 mg/ML
Storage:
3 years -20oC powder, 6 months-80oC in solvent.
MSDS:
Inquire
Quality Standard:
In-house
Quantity:
Grams-Kilos
InChIKey:
DFSYBWLNYPEFJK-IHLRWNDRSA-N
InChI:
InChI=1S/C32H48N4O8.ClH/c1-18-14-22-27(34-12-13-36(5)6)24(37)17-23(29(22)39)35-31(40)19(2)10-9-11-25(42-7)30(44-32(33)41)21(4)16-20(3)28(38)26(15-18)43-8;/h9-11,16-18,20,25-26,28,30,34,38H,12-15H2,1-8H3,(H2,33,41)(H,35,40);1H/b11-9-,19-10+,21-16+;/t18-,20+,25+,26+,28-,30+;/m1./s1
Canonical SMILES:
CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCN(C)C)C)OC)OC(=O)N)C)C)O)OC.Cl
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Hsp90 Products


CAS 467214-20-6 Alvespimycin

Alvespimycin
(CAS: 467214-20-6)

Alvespimycin (17-DMAG; KOS-1022; NSC 707545) is a potent, H2O-soluble Hsp90 inhibitor with IC50 of 62 nM.17-DMAG displays ~2 times potency against human Hsp90 t...

CAS 848695-25-0 BIIB021

BIIB021
(CAS: 848695-25-0)

BIIB021 is An orally active, purine-scaffold, small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. BIIB021 that is ...

PU-WS13
(CAS: 1454619-14-7)

PU-WS13 is a cell-permeable inhibitor of Grp94 (EC50 = 220 nM).It shows selectivity for Grp94 over the related Hsps Trap-1, Hsp90α, and Hsp90β. PU-WS13 blocks t...

CAS 171009-07-7 CCT018159

CCT018159
(CAS: 171009-07-7)

CCT018159 is a novel inhibitor of heat shock protein (Hsp) 90 with potential anticancer activity. CCT018159 inhibited human Hsp90beta with comparable potency to...

CAS 1196723-93-9 HSF1A

HSF1A
(CAS: 1196723-93-9)

HSF1A is a cell-permeable human heat shock factor protein (HSP1) activator.

CAS 934343-74-5 Hsp990

Hsp990
(CAS: 934343-74-5)

Hsp980 is an orally bioavailable inhibitor of human heat-shock protein 90 (Hsp90) with potential antineoplastic activity.  Hsp980 binds to and inhibits the acti...

CAS 1046859-34-0 PF-04942487

PF-04942487
(CAS: 1046859-34-0)

PF-4942847 is a novel oral Hsp90 inhibitor, which is a candidate for clinical development in TNBC by collaboratively targeting multiple signaling pathways. In a...

CAS 39868-96-7 Chlorobiocin

Chlorobiocin
(CAS: 39868-96-7)

Chlorobiocin is found to bind at a second ATP-binding site in the C-terminal domain of Hsp90, thus disrupting the dimerization of the Hsp90 complex.IC50 60μmol/...

CAS 64202-81-9 17-AG

17-AG
(CAS: 64202-81-9)

An orally bioavailable formulation of the ansamycin derivative 17-amino-17-demethoxygeldanamycin (17-AG) with potential antineoplastic activity. Oral Hsp90 inhi...

C086
(CAS: 1160107-44-7)

C086 inhibits Hsp90 and BCR-ABL, resulting in decreased proliferation of tumor cells, including imatinib-resistant cells.

CAS 819812-04-9 KW-2478

KW-2478
(CAS: 819812-04-9)

KW-2478 is an agent that targets the human heat-shock protein 90 (Hsp90) with potential antineoplastic activity. Although the mechanism of action remains to be ...

CAS 1134156-31-2 VER-155008

VER-155008
(CAS: 1134156-31-2)

VER-155008 is an adenosine-derived inhibitor of heat shock protein 70 (Hsp70; IC50 = 0.5 µM) that is selective over Hsp90.It targets the nucleotide-binding doma...

CAS 747413-08-7 VER-50589

VER-50589
(CAS: 747413-08-7)

VER-50589 is a potent Hsp90 inhibitor with IC50 of 21 nM for Hsp90β.

CAS 857402-23-4 Retaspimycin

Retaspimycin
(CAS: 857402-23-4)

Retaspimycin(IPI 504) is a small-molecule inhibitor of heat shock protein 90 (Hsp90) with antiproliferative and antineoplastic activities.Retaspimycin binds to ...

CAS 467214-21-7 Alvespimycin HCl

Alvespimycin HCl
(CAS: 467214-21-7)

Alvespimycin hydrochloride is the hydrochloride salt of alvespimycin, an analogue of the antineoplastic benzoquinone antibiotic geldanamycin. Alvespimycin binds...

VER-49009
(CAS: 558640-51-0)

VER-49009 a protein 90 (HSP90) inhibitor(IC50= 47 nM).

CAS 467214-20-6 Alvespimycin

Alvespimycin
(CAS: 467214-20-6)

Alvespimycin (17-DMAG; KOS-1022; NSC 707545) is a potent, H2O-soluble Hsp90 inhibitor with IC50 of 62 nM.17-DMAG displays ~2 times potency against human Hsp90 t...

CAS 30562-34-6 Geldanamycin

Geldanamycin
(CAS: 30562-34-6)

Geldanamycin is a benzoquinone ansamycin antibiotic that binds to Hsp90 (Heat Shock Protein 90) and inhibits its function. Hsp90 client proteins play important ...

CAS 30562-34-6 Geldanamycin

Geldanamycin
(CAS: 30562-34-6)

Geldanamycin is a benzoquinone ansamycin antibiotic that binds to Hsp90 (Heat Shock Protein 90) and inhibits its function. Hsp90 client proteins play important ...

KNK437
(CAS: 218924-25-5)

KNK437 is a pan-HSP inhibitor, which inhibits the synthesis of inducible HSPs, including HSP105, HSP72, and HSP40.

Chemical Structure

CAS 467214-21-7 Alvespimycin HCl

Quick Inquiry

Verification code

Featured Items