Alvameline - CAS 120241-31-8
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C9H15N5
Molecular Weight:
193.25
COA:
Inquire
Targets:
mAChR
Description:
Alvameline, also known as Lu25-109, is a partial M1agonist and M2/M3antagonist that was progressed into clinical studies for the treatment of Alzheimer's disease and Urinary incontinence but was subsequently discontinued.
Brife Description:
A partial M1 agonist and M2/M3 antagonist
Synonyms:
5-(2-ethyltetrazol-5-yl)-1-methyl-3,6-dihydro-2H-pyridine; 5-(2-ethyl-2H-tetrazol-5-yl)-1,2,3,6-tetrahydro-1-methylpyridine tartrate; LU 25-109; LU 25-109-T; LU-25-109-T
Solubility:
DMSO
Storage:
Store in a cool and dry place (or refer to the Certificate of Analysis).
MSDS:
Inquire
Boiling Point:
342.1±52.0 ℃ at 760 Torr
Density:
1.25±0.1 g/cm3
InChIKey:
RNMOMKCRCIRYCZ-UHFFFAOYSA-N
InChI:
1S/C9H15N5/c1-3-14-11-9(10-12-14)8-5-4-6-13(2)7-8/h5H,3-4,6-7H2,1-2H3
Canonical SMILES:
CCN1N=C(N=N1)C2=CCCN(C2)C
1.Activating the posttraumatic cholinergic system for the treatment of cognitive impairment following traumatic brain injury.
Pike BR;Hamm RJ Pharmacol Biochem Behav. 1997 Aug;57(4):785-91.
Cognitive impairment after traumatic brain injury (TBI) is correlated with decreased cholinergic markers of neuronal viability. The purpose of this experiment was to test the hypothesis that pharmacological activation of the muscarinic cholinergic system during the recovery period after TBI will improve cognitive performance. LU 25-109-T is a partial muscarinic M1 agonist that also acts as an antagonist at presynaptic M2 autoreceptors (thus increasing ACh release). Injured rats were injected subcutaneously daily for 15 days with either 0.0, 3.6, or 15 mumol/kg of LU 25-109-T beginning 24 h after a receiving a moderate (2.1 +/- 0.1 atm) level of central fluid percussion brain injury. Cognitive performance was assessed on days 11-15 postinjury in a Morris water maze (MWM). Injured rats treated with 15 mumol/kg, but not those treated with 3.6 mumol/kg, showed a significant improvement (p < 0.01) in MWM performance as compared with injured vehicle-treated rats. This result supports the hypotheses that a decrease in posttraumatic cholinergic neurotransmission contributes to TBI-induced cognitive deficits and that increasing cholinergic tone during the recovery period following TBI will improve cognitive performance.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related mAChR Products


CAS 146422-58-4 CDD0102

CDD0102
(CAS: 146422-58-4)

CDD0102 is a selective M1 agonist which stimulated the secretion of APP from CHO-K1 cells expressing M1 receptors and penetrated into the brain following i.p. a...

CAS 136722-45-7 MDL 201012

MDL 201012
(CAS: 136722-45-7)

MDL 201012 is a selective M3 muscarinic receptor antagonist used as an antimuscarinic agent.

CAS 1098-97-1 Pyrithioxin

Pyrithioxin
(CAS: 1098-97-1)

Pyrithioxin, a pyridine thiol derivatives, could be used in the treatment of traumatic brain injury sequelae and some sorts of cerebral infarct patients with He...

CAS 107233-08-9 Cevimeline

Cevimeline
(CAS: 107233-08-9)

Cevimeline is a selective M1 receptor agonist.

CAS 23062-91-1 PD 102807

PD 102807
(CAS: 23062-91-1)

PD 102807 is a selective mAChR M4 antagonist with IC50 values of 91, 6559, 3441, 95 and 7412 nM for human M4, M1, M2, M3, and M5 receptors respectively.

CAS 131780-48-8 DAU 5884 hydrochloride

DAU 5884 hydrochloride
(CAS: 131780-48-8)

DAU 5884 hydrochloride is a selective muscarinic M3 receptor antagonist. It inhibits methacholine-dependent effects on cell proliferation and muscle contractili...

CAS 1208222-39-2 VU 0365114

VU 0365114
(CAS: 1208222-39-2)

VU 0365114 is a selective positive allosteric modulator of M5 muscarinic acetylcholine receptor (mAChR) (EC50 = 2.7 μM for human M5, and >30 μM for M1, M2, M3 a...

CAS 147202-94-6 Arecaidine propargyl ester tosylate

Arecaidine propargyl ester tosylate
(CAS: 147202-94-6)

Arecaidine propargyl ester tosylate is a potent muscarinic receptor agonist. It displays some selectivity for cardiac versus ileal M2 receptors.

Chemical Structure

CAS 120241-31-8 Alvameline

Quick Inquiry

Verification code

Featured Items