Alprenolol - CAS 13655-52-2
Catalog number:
13655-52-2
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C15H23NO2
Molecular Weight:
249.35
COA:
Inquire
Targets:
5-HT Receptor | Adrenergic Receptor
Description:
Alprenolol is a non-selective Beta-Adrenergic receptor and 5-HT1A receptor antagonist for the treatment of angina pectoris.
Publictions citing BOC Sciences Products
  • >> More
Purity:
95%
Appearance:
Powder
Synonyms:
Alprenolol;1-Isopropylamino-3-(2-allyl)phenoxypropan-2-ol;2-Propanol, 1-[(1-methylethyl)amino]-3-[2-(2-propenyl)phenoxy]-;Alpheprol;dl-Alprenolol;ALLPRENOLOL;13707-88-5(Hydrochloride)
Solubility:
Soluble in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
angina pectoris
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
Boiling Point:
383.4ºC at 760mmHg
Density:
1.007g/cm3
InChIKey:
PAZJSJFMUHDSTF-UHFFFAOYSA-N
InChI:
InChI=1S/C15H23NO2/c1-4-7-13-8-5-6-9-15(13)18-11-14(17)10-16-12(2)3/h4-6,8-9,12,14,16-17H,1,7,10-11H2,2-3H3
Canonical SMILES:
CC(C)NCC(COC1=CC=CC=C1CC=C)O
1.Determination of chiral pharmaceuticals and illicit drugs in wastewater and sludge using microwave assisted extraction, solid-phase extraction and chiral liquid chromatography coupled with tandem mass spectrometry.
Evans SE1, Davies P1, Lubben A1, Kasprzyk-Hordern B2. Anal Chim Acta. 2015 Jul 2;882:112-26. doi: 10.1016/j.aca.2015.03.039. Epub 2015 Mar 28.
This is the first study presenting a multi-residue method allowing for comprehensive analysis of several chiral pharmacologically active compounds (cPACs) including beta-blockers, antidepressants and amphetamines in wastewater and digested sludge at the enantiomeric level. Analysis of both the liquid and solid matrices within wastewater treatment is crucial to being able to carry out mass balance within these systems. The method developed comprises filtration, microwave assisted extraction and solid phase extraction followed by chiral liquid chromatography coupled with tandem mass spectrometry to analyse the enantiomers of 18 compounds within all three matrices. The method was successfully validated for 10 compounds within all three matrices (amphetamine, methamphetamine, MDMA, MDA, venlafaxine, desmethylvenlafaxine, citalopram, metoprolol, propranolol and sotalol), 7 compounds validated for the liquid matrices only (mirtazapine, salbutamol, fluoxetine, desmethylcitalopram, atenolol, ephedrine and pseudoephedrine) and 1 compound (alprenolol) passing the criteria for solid samples only.
2.Blood pressure lowering efficacy of partial agonist beta blocker monotherapy for primary hypertension.
Wong GW1, Boyda HN, Wright JM. Cochrane Database Syst Rev. 2014 Nov 27;11:CD007450. doi: 10.1002/14651858.CD007450.pub2.
BACKGROUND: Partial agonists are a subclass of beta blockers used to treat hypertension in many countries. Partial agonist act by stimulating beta receptors when they are quiescent and blocking beta receptors when they are active. The blood pressure (BP) lowering effect of partial agonist beta blockers has not been quantified.
3.Immobilized β-cyclodextrin-based silica vs polymer monoliths for chiral nano liquid chromatographic separation of racemates.
Ghanem A1, Ahmed M2, Ishii H3, Ikegami T3. Talanta. 2015 Jan;132:301-14. doi: 10.1016/j.talanta.2014.09.006. Epub 2014 Sep 16.
The enantioselectivity of immobilized β-cyclodextrin phenyl carbamate-based silica monolithic capillary columns was compared to our previously described polymer counterpart. 2,3,6-Tris(phenylcarbamoyl)-β-cyclodextrin-6-methacrylate was used as a functional monomer for the preparation of β-cyclodextrin (β-CD)-based silica and polymer monoliths. The silica monoliths were prepared via the sol-gel technique in fused silica capillary followed by modification of the bare silica monoliths with an anchor group prior to polymerization with β-CD methacrylate using either 2,2'-azobis(isobutyronitrile) or benzoylperoxide as radical initiators. On the other hand, the polymer monoliths were prepared via the copolymerization of β-CD methacrylate and ethylene glycol dimethacrylate in different ratios in situ in fused silica capillary. The prepared silica/polymer monoliths were investigated for the chiral separation of different classes of pharmaceuticals namely; α- and β-blockers, anti-inflammatory drugs, antifungal drugs, dopamine antagonists, norepinephrine-dopamine reuptake inhibitors, catecholamines, sedative hypnotics, diuretics, antihistaminics, anticancer drugs and antiarrhythmic drugs.
4.When barriers ignore the "rule-of-five".
Krämer SD1, Aschmann HE2, Hatibovic M2, Hermann KF2, Neuhaus CS2, Brunner C2, Belli S3. Adv Drug Deliv Rev. 2016 Feb 12. pii: S0169-409X(16)30051-5. doi: 10.1016/j.addr.2016.02.001. [Epub ahead of print]
Why are a few drugs with properties beyond the rule of 5 (bRo5) absorbed across the intestinal mucosa while most other bRo5 compounds are not? Are such exceptional bRo5 compounds exclusively taken up by carrier-mediated transport or are they able to permeate the lipid bilayer (passive lipoidal diffusion)? Our experimental data with liposomes indicate that tetracycline, which violates one rule of the Ro5, and rifampicin, violating three of the rules, significantly permeate a phospholipid bilayer with kinetics similar to labetalol and metoprolol, respectively. Published data from experimental work and molecular dynamics simulations suggest that the formation of intramolecular H-bonds and the possibility to adopt an elongated shape besides the presence of a significant fraction of net neutral species facilitate lipid bilayer permeation. As an alternative to lipid bilayer permeation, carrier proteins can be targeted to improve absorption, with the potential drawbacks of drug-drug interactions and non-linear pharmacokinetics.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related 5-HT Receptor Products


CAS 753498-25-8 Indacaterol Maleate

Indacaterol Maleate
(CAS: 753498-25-8)

Indacaterol is an ultra-long-acting β-adrenoceptor agonist with pKi of 7.36.

CAS 51781-21-6 Carteolol Hydrochloride

Carteolol Hydrochloride
(CAS: 51781-21-6)

Carteolol HCl is a β-adrenoceptor antagonist, used for the treatment of glaucoma.

(R)-6-Hydroxybuspirone hydrochloride
(CAS: 477930-30-6)

(R)-6-Hydroxybuspirone is a major active metabolite of Buspirone. (R)-Enantiomer showed higher affinity and selectivity for the 5HT1A receptor compared to the ...

CAS 1220646-23-0 AVN-492

AVN-492
(CAS: 1220646-23-0)

AVN-492 is a novel highly-potent and highly-selective 5-HT6R antagonist. The affinity of AVN-492 to bind to 5-HT6R (Ki = 91 pM) was more than three orders of ma...

CAS 59-98-3 Tolazoline

Tolazoline
(CAS: 59-98-3)

Tolazoline is a non-selective competitive α-adrenergic receptor antagonist used in treatment of persistent pulmonary hypertension of the newborn..

CAS 89365-50-4 Salmeterol

Salmeterol
(CAS: 89365-50-4)

Salmeterol is a long-acting beta2-adrenergic receptor (beta 2AR) agonist. It is used clinically in the maintenance and prevention of asthma symptoms and mainten...

CAS 226081-74-9 AR-​08

AR-​08
(CAS: 226081-74-9)

AR-​08 is an agonist of α2-adrenergic receptor undergone in phase II clinical trials by Arbor Pharmaceuticals for the treatment of attention deficit and hyperac...

CAS 5189-11-7 Pizotifen Malate

Pizotifen Malate
(CAS: 5189-11-7)

Pizotifen Malate is a benzocycloheptane based agent used for recurrent migraine headaches.

CAS 189188-57-6 Tegaserod maleate

Tegaserod maleate
(CAS: 189188-57-6)

Tegaserod maleate is a partial agonist of the 5-HT4 receptor (Ki = 12 nM) that can treat irritable bowel syndrome (IBS).

CAS 122852-42-0 Alosetron

Alosetron
(CAS: 122852-42-0)

Alosetron, an effective 5-HT3 receptor antagonist, could be commonly used against irritable bowel syndrome.

CAS 36085-73-1 B-HT 920 dihydrochloride

B-HT 920 dihydrochloride
(CAS: 36085-73-1)

Talipexole is a D2 dopamine receptor agonist, displaying anti-Parkinsonian activity.

CAS 132539-06-1 Olanzapine

Olanzapine
(CAS: 132539-06-1)

Olanzapine interacts with key receptors of interest in schizophrenia, having a nanomolar affinity for dopaminergic, serotonergic, alpha 1-adrenergic, and muscar...

Aptazapine maleate
(CAS: 71576-41-5)

Aptazapine is a tetracyclic antidepressant. It was assayed in clinical trials for the treatment of depression in the 1980s but was never marketed. Aptazapine is...

CAS 10457-90-6 Bromperidol

Bromperidol
(CAS: 10457-90-6)

Bromperidol, a derivative of butyrophenone, is an antipsychotic commonly used in the treatment of schizophrenia as it could bind to the D2 dopamine and 5-HT2A s...

CAS 179756-58-2 Eptapirone

Eptapirone
(CAS: 179756-58-2)

Eptapirone, also known as F11440, is a potent agonist of the serotonin (5-HT) receptor subtype 5-HT1A (Ki = 4.8 nM in a radioligand binding assay).

CAS 5874-97-5 Metaproterenol hemisulfate salt

Metaproterenol hemisulfate salt
(CAS: 5874-97-5)

Metaproterenol hemisulfate salt is the hemisulfate salt form of Metaproterenol, which is a moderately selective beta-adrenergic agonist. It is used in the treat...

CAS 143322-58-1 Eletriptan

Eletriptan
(CAS: 143322-58-1)

Eletriptan is Serotonin 1D receptor agonist originated by Pfizer. It is a second generation triptan drug. It is used as an abortive medication, blocking a migra...

CAS 158930-09-7 Frovatriptan Succinate

Frovatriptan Succinate
(CAS: 158930-09-7)

Thesuccinate salt form of Frovatriptan, a carbazole derivative, has been found to be a 5-HT receptor agonist that could be used as an antimigraine agent.

CAS 70024-40-7 Terazosin HCl

Terazosin HCl
(CAS: 70024-40-7)

Terazosin is a selective alpha 1 antagonist used for treatment of symptoms of an enlarged prostate (BPH).

CAS 1977-10-2 Loxapine

Loxapine
(CAS: 1977-10-2)

Loxapine is a typical antipsychotic medication, used primarily in the treatment of schizophrenia and it is a D2/D4 dopamine receptor antagonist; 5-HT2A/2B, 5-H7...

Chemical Structure

CAS 13655-52-2 Alprenolol

Quick Inquiry

Verification code

Featured Items