Alprenolol - CAS 13655-52-2
Catalog number:
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
5-HT Receptor | Adrenergic Receptor
Alprenolol is a non-selective Beta-Adrenergic receptor and 5-HT1A receptor antagonist for the treatment of angina pectoris.
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Alprenolol;1-Isopropylamino-3-(2-allyl)phenoxypropan-2-ol;2-Propanol, 1-[(1-methylethyl)amino]-3-[2-(2-propenyl)phenoxy]-;Alpheprol;dl-Alprenolol;ALLPRENOLOL;13707-88-5(Hydrochloride)
Soluble in DMSO
-20°C Freezer
angina pectoris
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Boiling Point:
383.4ºC at 760mmHg
Canonical SMILES:
1.Determination of chiral pharmaceuticals and illicit drugs in wastewater and sludge using microwave assisted extraction, solid-phase extraction and chiral liquid chromatography coupled with tandem mass spectrometry.
Evans SE1, Davies P1, Lubben A1, Kasprzyk-Hordern B2. Anal Chim Acta. 2015 Jul 2;882:112-26. doi: 10.1016/j.aca.2015.03.039. Epub 2015 Mar 28.
This is the first study presenting a multi-residue method allowing for comprehensive analysis of several chiral pharmacologically active compounds (cPACs) including beta-blockers, antidepressants and amphetamines in wastewater and digested sludge at the enantiomeric level. Analysis of both the liquid and solid matrices within wastewater treatment is crucial to being able to carry out mass balance within these systems. The method developed comprises filtration, microwave assisted extraction and solid phase extraction followed by chiral liquid chromatography coupled with tandem mass spectrometry to analyse the enantiomers of 18 compounds within all three matrices. The method was successfully validated for 10 compounds within all three matrices (amphetamine, methamphetamine, MDMA, MDA, venlafaxine, desmethylvenlafaxine, citalopram, metoprolol, propranolol and sotalol), 7 compounds validated for the liquid matrices only (mirtazapine, salbutamol, fluoxetine, desmethylcitalopram, atenolol, ephedrine and pseudoephedrine) and 1 compound (alprenolol) passing the criteria for solid samples only.
2.Blood pressure lowering efficacy of partial agonist beta blocker monotherapy for primary hypertension.
Wong GW1, Boyda HN, Wright JM. Cochrane Database Syst Rev. 2014 Nov 27;11:CD007450. doi: 10.1002/14651858.CD007450.pub2.
BACKGROUND: Partial agonists are a subclass of beta blockers used to treat hypertension in many countries. Partial agonist act by stimulating beta receptors when they are quiescent and blocking beta receptors when they are active. The blood pressure (BP) lowering effect of partial agonist beta blockers has not been quantified.
3.Immobilized β-cyclodextrin-based silica vs polymer monoliths for chiral nano liquid chromatographic separation of racemates.
Ghanem A1, Ahmed M2, Ishii H3, Ikegami T3. Talanta. 2015 Jan;132:301-14. doi: 10.1016/j.talanta.2014.09.006. Epub 2014 Sep 16.
The enantioselectivity of immobilized β-cyclodextrin phenyl carbamate-based silica monolithic capillary columns was compared to our previously described polymer counterpart. 2,3,6-Tris(phenylcarbamoyl)-β-cyclodextrin-6-methacrylate was used as a functional monomer for the preparation of β-cyclodextrin (β-CD)-based silica and polymer monoliths. The silica monoliths were prepared via the sol-gel technique in fused silica capillary followed by modification of the bare silica monoliths with an anchor group prior to polymerization with β-CD methacrylate using either 2,2'-azobis(isobutyronitrile) or benzoylperoxide as radical initiators. On the other hand, the polymer monoliths were prepared via the copolymerization of β-CD methacrylate and ethylene glycol dimethacrylate in different ratios in situ in fused silica capillary. The prepared silica/polymer monoliths were investigated for the chiral separation of different classes of pharmaceuticals namely; α- and β-blockers, anti-inflammatory drugs, antifungal drugs, dopamine antagonists, norepinephrine-dopamine reuptake inhibitors, catecholamines, sedative hypnotics, diuretics, antihistaminics, anticancer drugs and antiarrhythmic drugs.
4.When barriers ignore the "rule-of-five".
Krämer SD1, Aschmann HE2, Hatibovic M2, Hermann KF2, Neuhaus CS2, Brunner C2, Belli S3. Adv Drug Deliv Rev. 2016 Feb 12. pii: S0169-409X(16)30051-5. doi: 10.1016/j.addr.2016.02.001. [Epub ahead of print]
Why are a few drugs with properties beyond the rule of 5 (bRo5) absorbed across the intestinal mucosa while most other bRo5 compounds are not? Are such exceptional bRo5 compounds exclusively taken up by carrier-mediated transport or are they able to permeate the lipid bilayer (passive lipoidal diffusion)? Our experimental data with liposomes indicate that tetracycline, which violates one rule of the Ro5, and rifampicin, violating three of the rules, significantly permeate a phospholipid bilayer with kinetics similar to labetalol and metoprolol, respectively. Published data from experimental work and molecular dynamics simulations suggest that the formation of intramolecular H-bonds and the possibility to adopt an elongated shape besides the presence of a significant fraction of net neutral species facilitate lipid bilayer permeation. As an alternative to lipid bilayer permeation, carrier proteins can be targeted to improve absorption, with the potential drawbacks of drug-drug interactions and non-linear pharmacokinetics.
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CAS 13655-52-2 Alprenolol

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