alpha-Mangostin - CAS 6147-11-1
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C24H26O6
Molecular Weight:
410.46
COA:
Inquire
Targets:
Cox-2 | Isocitrate Dehydrogenase (IDH)
Description:
Alpha-mangostin, a prenylated xanthone derivative from Mangosteen, Garcinia mangostana L. (Clusiaceae), has shown to possess diverse pharmacological activities blended with profound antioxidant and antiinflammatory properties. Alpha-mangostin has been reported to inhibit COX-2 activities in vitro in C6 rat glioma cells. Besides, Alpha-mangostin is an inhibitor of mutant IDH1 (IDH1-R132H) (Ki= 2.85 μM).
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Brife Description:
Inhibit COX-2 activities; an inhibitor of mutant IDH1 (IDH1-R132H)
Synonyms:
1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-enyl)xanthen-9-one; alpha-mangostin; delta-mangostin; mangostin
Solubility:
DMSO: ≥ 37 mg/mL
Storage:
Store in a cool and dry place (or refer to the Certificate of Analysis).
MSDS:
Inquire
Boiling Point:
640.1±55.0 ℃ at 760 Torr
Melting Point:
180-181 ℃
Density:
1.265±0.06 g/cm3
InChIKey:
GNRIZKKCNOBBMO-UHFFFAOYSA-N
InChI:
1S/C24H26O6/c1-12(2)6-8-14-16(25)10-19-21(22(14)27)23(28)20-15(9-7-13(3)4)24(29-5)17(26)11-18(20)30-19/h6-7,10-11,25-27H,8-9H2,1-5H3
Canonical SMILES:
CC(=CCC1=C(C=C2C(=C1O)C(=O)C3=C(C(=C(C=C3O2)O)OC)CC=C(C)C)O)C
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CAS 6147-11-1 alpha-Mangostin

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