Almotriptan - CAS 154323-57-6
Catalog number:
154323-57-6
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C17H25N3O2S
Molecular Weight:
335.46
COA:
Inquire
Targets:
5-HT Receptor
Description:
Almotriptan, also called as Almogran, is a agonist with high and specific affinity for 5-HT1B/1D receptors. developed by Almirall Prodesfarma for the acute treatment of migraine with or without aura. Besides, it acts very selectively at human cranial vess
Publictions citing BOC Sciences Products
  • >> More
Appearance:
Solid powder
Synonyms:
N,N-dimethyl-2-[5-(pyrrolidin-1-ylsulfonylmethyl)-1H-indol-3-yl]ethanamine Almotriptan 154323-57-6 Almogran Almotrintan LAS-31416 UNII-1O4XL5SN61 Almotriptan (USAN) CHEBI:520985 Spectrum_001884
Solubility:
Soluble to 95 mg/mL in DMSO
Storage:
Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -71℃ for long term (months to years).
MSDS:
Inquire
Shelf Life:
2 years
Quantity:
Grams-Kilos
Density:
1.27 g/cm3
InChIKey:
WKEMJKQOLOHJLZ-UHFFFAOYSA-N
InChI:
1S/C17H25N3O2S/c1-19(2)10-7-15-12-18-17-6-5-14(11-16(15)17)13-23(21,22)20-8-3-4-9-20/h5-6,11-12,18H,3-4,7-10,13H2,1-2H3
Canonical SMILES:
CN(C)CCC1=CNC2=C1C=C(C=C2)CS(=O)(=O)N3CCCC3
1.The acute treatment of migraine in adults: the american headache society evidence assessment of migraine pharmacotherapies.
Marmura MJ1, Silberstein SD, Schwedt TJ. Headache. 2015 Jan;55(1):3-20. doi: 10.1111/head.12499.
The study aims to provide an updated assessment of the evidence for individual pharmacological therapies for acute migraine treatment. Pharmacological therapy is frequently required for acutely treating migraine attacks. The American Academy of Neurology Guidelines published in 2000 summarized the available evidence relating to the efficacy of acute migraine medications. This review, conducted by the members of the Guidelines Section of the American Headache Society, is an updated assessment of evidence for the migraine acute medications. A standardized literature search was performed to identify articles related to acute migraine treatment that were published between 1998 and 2013. The American Academy of Neurology Guidelines Development procedures were followed. Two authors reviewed each abstract resulting from the search and determined whether the full manuscript qualified for review. Two reviewers studied each qualifying full manuscript for its level of evidence.
2.Efficacy of frovatriptan as compared to other triptans in migraine with aura.
Evers S1, Savi L, Omboni S, Lisotto C, Zanchin G, Pinessi L. J Headache Pain. 2015;16:514. doi: 10.1186/s10194-015-0514-8. Epub 2015 Apr 1.
BACKGROUND: The treatment of migraine attacks with aura by triptans is difficult since triptans most probably are not efficacious when taken during the aura phase. Moreover, there are insufficient data from randomised studies whether triptans are efficacious in migraine attacks with aura when taken during the headache phase. In this metaanalysis, we aimed to compare the efficacy of frovatriptan versus rizatriptan, zolmitriptan, and almotriptan.
3.Gellan gum-based mucoadhesive microspheres of almotriptan for nasal administration: Formulation optimization using factorial design, characterization, and in vitro evaluation.
Abbas Z1, Marihal S1. J Pharm Bioallied Sci. 2014 Oct;6(4):267-77. doi: 10.4103/0975-7406.142959.
BACKGROUND: Almotriptan malate (ALM), indicated for the treatment of migraine in adults is not a drug candidate feasible to be administered through the oral route during the attack due to its associated symptoms such as nausea and vomiting. This obviates an alternative dosage form and nasal drug delivery is a good substitute to oral and parenteral administration.
4.The therapeutic armamentarium in migraine is quite elderly.
Martelletti P1. Expert Opin Drug Metab Toxicol. 2015 Feb;11(2):175-7. doi: 10.1517/17425255.2015.982089. Epub 2014 Dec 1.
Global Burden of Disease 2010 study considers migraine as one of the most important noncommunicable diseases in the world, classifying it third in terms of global prevalence (14.70%): it sums up the 54.19% of all the years of life lived with disabilities caused by the rest of all neurological disorders. This Editorial provides an historical excursus of old and new-entry molecules in migraine therapeutic area. Drugs for acute treatment such as triptans date back to the early 1990s with the appearance of sumatriptan and the following six triptans in the years immediately after (zolmitriptan, rizatriptan, naratriptan, eletriptan, almotriptan, frovatriptan). Prophylaxis drugs, dedicated to patients with medium/high frequency of crises, show as last entries topiramate and botulinum toxin type A. The use of this preventative group, with its intrinsic limits, is mandatory to reduce the risk of migraine chronification, a highly harmful clinical phenomenon that produces as its natural consequence the medication overuse headache.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related 5-HT Receptor Products


CAS 186544-26-3 LY 344864

LY 344864
(CAS: 186544-26-3)

LY 344864 is a brain penetrant, full agonist that specifically targets 5-HT1F receptor (pKi = 8.2) with > 80-fold selectivity over other serotonin receptors (Ki...

CAS 37115-32-5 Adinazolam

Adinazolam
(CAS: 37115-32-5)

Adinazolam, a triazolobenzodiazepine, a high affinity for β-adrenoceptors (Kd = 0.061 nM) and alters the expression of serotonin 5-HT2 receptors in rat fronto-p...

SUVN-D4010
(CAS: 1428862-32-1)

SUVN-D4010 is a selective Serotonin 4 receptor partial agonist originated by Suven Life Sciences. Phase I clinical trials for the treatment of Alzheimer's disea...

CAS 154323-57-6 Almotriptan

Almotriptan
(CAS: 154323-57-6)

Almotriptan, also called as Almogran, is a agonist with high and specific affinity for 5-HT1B/1D receptors. developed by Almirall Prodesfarma for the acute trea...

CAS 85650-52-8 Mirtazapine

Mirtazapine
(CAS: 85650-52-8)

Mirtazapine is a potent tetracyclic antidepressant.

CAS 152811-62-6 Piboserod

Piboserod
(CAS: 152811-62-6)

Piboserod is a highly and potent selective 5-HT4 receptor antagonist which as been studied in vitro as well as in vivo as a pharmacological tool to evaluate the...

CAS 442-51-3 Harmine

Harmine
(CAS: 442-51-3)

Harmine induces apoptosis and inhibits proliferation, migration and invasion of human gastric cancer cells, which may be mediated by down-regulation of COX-2 ex...

CAS 107429-63-0 Lintopride

Lintopride
(CAS: 107429-63-0)

Lintopride, also called as ACEMM, a new benzamid, is a 5HT4 antagonist with moderate 5HT3 antagonist properties that increases gastric emptying, stimulates antr...

CAS 179756-85-5 Eptapirone

Eptapirone
(CAS: 179756-85-5)

Eptapirone, a triazine derivative, has been found to be a 5-HT1A receptor agonist and was once studied as an antidepressant agent. pKi: 8.33.

CAS 27833-64-3 Loxapine Succinate

Loxapine Succinate
(CAS: 27833-64-3)

Loxapine Succinate is a D2DR and D4DR inhibitor, serotonergic receptor antagonist and also a dibenzoxazepine anti-psychotic agent.oxapine is a typical antipsych...

CAS 103639-04-9 Ondansetron Hydrochloride Dihydrate

Ondansetron Hydrochloride Dihydrate
(CAS: 103639-04-9)

Ondansetron hydrochloride dihydrate is a specific and competitive antagonist of serotonin 5-HT3 receptor (Ki = 0.77 nM) with anxiolytic and neuroleptic activiti...

CAS 158930-09-7 Frovatriptan Succinate

Frovatriptan Succinate
(CAS: 158930-09-7)

Thesuccinate salt form of Frovatriptan, a carbazole derivative, has been found to be a 5-HT receptor agonist that could be used as an antimigraine agent.

CAS 508233-74-7 Vortioxetine

Vortioxetine
(CAS: 508233-74-7)

Vortioxetine (Lu AA21004) is a multimodal serotonergic agent, inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT with IC50 of 15 nM, 33 nM, 3.7 nM, 19 nM ...

CAS 222318-55-0 (4E)-SUN9221

(4E)-SUN9221
(CAS: 222318-55-0)

A potent dual antagonist of α1-adrenergic receptor and 5-HT2 receptor

CAS 17321-77-6 Clomipramine HCl

Clomipramine HCl
(CAS: 17321-77-6)

Clomipramine HCl is a hydrochloride salt of clomipramine which is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) bl...

CAS 5560-59-8 Alverine Citrate

Alverine Citrate
(CAS: 5560-59-8)

Alverine Citrate is a highly potent competitive CXCR4 antagonist with EC50 of 0.3 nM.

CAS 138982-67-9 Ziprasidone hydrochloride monohydrate

Ziprasidone hydrochloride monohydrate
(CAS: 138982-67-9)

The hydrochloride monohydrate salt form of Ziprasidone, a benzothiazol derivative, has been found to be a 5HT2A and D2 receptor antagonist that could be used ag...

CAS 18016-80-3 Lisuride

Lisuride
(CAS: 18016-80-3)

Lisuride, an indoloquinoline derivative, has been found to be a dopamine D2 receptor agonist and could probably be effective in antimigraine as well as antipark...

CAS 115956-12-2 Dolasetron

Dolasetron
(CAS: 115956-12-2)

Dolasetron, a pseudopelletierine derivative, is a 5-HT3 receptor antagonist that could be used to relieve the nausea and vomiting caused by chemotherapy.

CAS 706779-91-1 Pimavanserin

Pimavanserin
(CAS: 706779-91-1)

Pimavanserin is a potent and selective 5-HT2A receptor inverse agonist used in the treatment of Parkinson’s disease psychosis.

Chemical Structure

CAS 154323-57-6 Almotriptan

Quick Inquiry

Verification code

Featured Items