Allopurinol - CAS 315-30-0
Catalog number: 315-30-0
Category: Inhibitor
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Molecular Formula:
Molecular Weight:
Xanthine oxidase (XAO)
Allopurinol is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 μM.
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1.Inhibition properties of propolis extracts to some clinically important enzymes.
Baltas N1, Yildiz O2, Kolayli S3. J Enzyme Inhib Med Chem. 2016 Apr 7:1-4. [Epub ahead of print]
The present study was conducted to envisage inhibition effects of propolis on the crucial enzymes, urease, xanthine oxidase (XO) and acetylcholinesterase (AChE). Some of the antioxidant properties of the propolis samples were determined using the total phenolic content (TPE) and total flavonoids in the eight different ethanolic propolis extracts (EPE) samples. Inhibition values of the enzymes were expressed as inhibition concentration (IC50; mg/mL or μg/mL) causing 50% inhibition of the enzymes with donepezil, acetohydroxamic acid and allopurinol as reference inhibitors. All the propolis extracts exhibited variable inhibition effects on these enzymes, but the higher the phenolic contents the lower the inhibitions values (IC50 = 0.074 to 1.560 mg/mL). IC50 values of the P5 propolis sample having the highest TPE, obtained from Zonguldak, for AChE, urease and XO were 0.081 ± 0.009, 0.080 ± 0.006 and 0.074 ± 0.011 μg/mL, respectively. The EPE proved to be a good source of inhibitor agents that can be used as natural inhibitors to serve human health.
2.Factors Associated with Preventive Pharmacological Therapy Adherence among Patients with Kidney Stones.
Dauw CA1, Yi Y1, Bierlein MJ1, Yan P1, Alruwaily AF1, Ghani KR1, Wolf JS1, Hollenbeck BK1, Hollingsworth JM2. Urology. 2016 Mar 31. pii: S0090-4295(16)30011-5. doi: 10.1016/j.urology.2016.03.030. [Epub ahead of print]
OBJECTIVE: To determine adherence patterns for thiazide diuretics, alkali citrate therapy, and allopurinol, collectively referred to as preventive pharmacological therapy (PPT), amongst patients with kidney stones.
3.Allopurinol preconditioning attenuates renal ischemia/reperfusion injury by inhibiting HMGB1 expression in a rat model.
Zhou JQ1, Qiu T1, Zhang L2, Chen ZB1, Wang ZS2, Ma XX1, Li D3. Acta Cir Bras. 2016 Mar;31(3):176-82. doi: 10.1590/S0102-865020160030000005.
PURPOSE: To investigate the potential effects of pretreatment with allopurinol on renal ischemia/reperfusion injury (IRI) in a rat model.
4.Evaluation of antigout activity of Phyllanthus emblica fruit extracts on potassium oxonate-induced gout rat model.
Sarvaiya VN1, Sadariya KA1, Pancha PG1, Thaker AM1, Patel AC2, Prajapati AS3. Vet World. 2015 Oct;8(10):1230-6. doi: 10.14202/vetworld.2015.1230-1236. Epub 2015 Oct 23.
AIM: The present study has been conducted to evaluate antigout activity of aqueous and alcoholic extracts of Phyllanthus emblica fruits following its 28 days repeated oral administration on potassium oxonate-induced gout rat model.
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