Allantoxanamide - CAS 69391-08-8
Catalog number: B0084-391558
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C4H4N4O3
Molecular Weight:
156.1
COA:
Inquire
Targets:
Others
Description:
Allantoxanamide was reported to be a novel inhibitor of uricase in vivo.
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-391558 10 mg $198 In stock
B0084-391558 50 mg $498 In stock
Bulk Inquiry
Purity:
95%
Synonyms:
4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazine-2-carboxamide; 4,6-dioxo-1H-1,3,5-triazine-2-carboxamide; 4-Hydroxy-6-oxo-1,6-dihydro-1,3,5-triazine-2-carboxamide
MSDS:
Inquire
InChIKey:
HJXJVORILFDIOT-UHFFFAOYSA-N
InChI:
InChI=1S/C4H4N4O3/c5-1(9)2-6-3(10)8-4(11)7-2/h(H2,5,9)(H2,6,7,8,10,11)
Canonical SMILES:
C1(=NC(=O)NC(=O)N1)C(=O)N
1.Decreasing effect of allantoxanamide, a hyperuricemic agent on renal functions in rats.
Yonetani Y1, Iwaki K, Ogawa Y. Jpn J Pharmacol. 1987 Sep;45(1):37-43.
Both potassium oxonate and allantoxanamide have been reported as useful reagents for inhibiting urate oxidase, with the hyperuricemic effect of allantoxanamide being longer-lasting than that of oxonate in rats. The present study was done to evaluate the utility of allantoxanamide for investigating problems concerning hyperuricemia using rats. A single intraperitoneal administration of 150 mg/kg allantoxanamide elevated the plasma uric acid level progressively during the experiment for 6 hr, resulting in a much higher level than that maintained by means of repeated dosing with 250 mg/kg potassium oxonate, i.p., at 2-hr intervals. Such a severe and long-lasting hyperuricemia caused by allantoxanamide was due to decreased renal function of uric acid excretion according to its nephrotoxicity in addition to the inhibition of urate oxidase like that by oxonate. Thus, we concluded that allantoxanamide might be a useful reagent for investigating the causes of hyperuricemia with renal failure, but was not a practical agent like oxonate in order to evaluate the response to uricosuric agents.
2.Allantoxanamide-induced myocardial necrosis in Sprague-Dawley vs spontaneously hypertensive rats.
Wexler BC. Proc Soc Exp Biol Med. 1982 Sep;170(4):476-85.
3.Uricostatic effect of allopurinol in the allantoxanamide-treated rat: a new method for evaluating antiuricopathic drugs.
Hropot M, Muschaweck R, Klaus E. Adv Exp Med Biol. 1984;165 Pt A:175-8.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products


CAS 12583-68-5 Parathyroid hormone (1-34) (bovine)

Parathyroid hormone (1-34) (bovine)
(CAS: 12583-68-5)

Parathyroid hormone (1-34) (bovine) is a parathyroid hormone (PTH) receptor agonist. It increases calcium and inorganic phosphate levels in the serum of young r...

CAS 60-27-5 Creatinine

Creatinine
(CAS: 60-27-5)

Creatinine is a break-down product of creatine phosphate in muscle, and is usually produced at a fairly constant rate by the body.

CAS 63717-27-1 Amifostine hydrate

Amifostine hydrate
(CAS: 63717-27-1)

Amifostine hydrate is a radiation-protective agent.

CAS 532-03-6 Methocarbamol

Methocarbamol
(CAS: 532-03-6)

Methocarbamol is a central muscle relaxant used to treat skeletal muscle spasms.

CAS 119793-66-7 Propionyl-L-Carnitine HCl

Propionyl-L-Carnitine HCl
(CAS: 119793-66-7)

The hydrochloride salt form of L-Propionylcarnitine which has been found to be related to mitochondrial metabolism so that could be used in the treatment deteri...

LTV-1
(CAS: 347379-29-7)

LTV-1, a highly potent inhibitor, inhibits LYP((IC50 = 508 nM)) in a dose-dependent manner at low- and sub-micromolar concentrations in T cells.

CAS 100929-71-3 β-NADPH tetra (cyclohexylammonium) salt

β-NADPH tetra (cyclohexylammonium) salt
(CAS: 100929-71-3)

β-NADPH tetra(cyclohexylammonium), generating in vivio by the pentose phosphate pathway, is a a ubiquitous cofactor and biological reducing agent.

CAS 7492-32-2 Isopropamide

Isopropamide
(CAS: 7492-32-2)

Isopropamide is a long-acting anticholinergic drug. It can be used for the treatment of peptic ulcers and other gastrointestinal disorders including hyperacidit...

Chemical Structure

CAS 69391-08-8 Allantoxanamide

Quick Inquiry

Verification code

Featured Items