Alizapride - CAS 59338-93-1
Catalog number: 59338-93-1
Category: Inhibitor
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Molecular Formula:
C16H21N5O2
Molecular Weight:
315.37
COA:
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Targets:
Dopamine Receptor
Description:
Alizapride is a dopamine antagonist. It has prokinetic and antiemetic effects and is used in the treatment of nausea and vomiting, including postoperative nausea and vomiting. It is structurally related to metoclopramide and other benzamides. It has been listed.
Purity:
98%
Appearance:
Solid powder
Synonyms:
N-(1-allyl-2-pyrrolidinylmethyl)-6-methoxy-1h-benzotriazole-5-carboxamide;1H-benzotriazole-5-carboxamide,6-methoxy-n-((1-(2-propenyl)-2-pyrrolidinyl)met;6-Methoxy-n-((1-(2-propenyl)-2-pyrrolidinyl)methyl)-1h-benzotriazole-5-carbo;6-Methoxy-N-{[1-(2-propny
Solubility:
Soluble in DMSO, not in water
Storage:
-20°C Freezer
MSDS:
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Application:
Alizapride has prokinetic and antiemetic effects and is used in the treatment of nausea and vomiting, including postoperative nausea and vomiting.
Quality Standard:
In-house standard
Quantity:
Grams to Kilograms
Boiling Point:
580.3±40.0 °C | Condition: Press: 760 Torr
Melting Point:
139 °C
Density:
1.224±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
InChIKey:
KSEYRUGYKHXGFW-UHFFFAOYSA-N
InChI:
InChI=1S/C16H21N5O2/c1-3-6-21-7-4-5-11(21)10-17-16(22)12-8-13-14(19-20-18-13)9-15(12)23-2/h3,8-9,11H,1,4-7,10H2,2H3,(H,17,22)(H,18,19,20)
Canonical SMILES:
COC1=CC2=NNN=C2C=C1C(=O)NCC3CCCN3CC=C
Current Developer:
Alizapride has been listed.
1.Study of the prophylactic effect of droperidol, alizapride, propofol and promethazine on spinal morphine-induced pruritus.
Horta ML1, Morejon LC, da Cruz AW, Dos Santos GR, Welling LC, Terhorst L, Costa RC, Alam RU. Br J Anaesth. 2006 Jun;96(6):796-800. Epub 2006 Apr 5.
BACKGROUND: We have compared the use of alizapride, propofol, droperidol and promethazine for the prevention of spinal morphine-induced pruritus.
2.The benefits and risks of different therapies in preventing postoperative nausea and vomiting in patients undergoing thyroid surgery.
Fujii Y1. Curr Drug Saf. 2008 Jan;3(1):27-34.
Postoperative nausea and vomiting (PONV) are distressing and frequent adverse events of anesthesia and surgery, with a relatively high incidence following thyroidectomy. These symptoms predispose to aspiration of gastric contents, increased intraocular pressure, psychological distress, and delayed recovery and discharge times. Numerous antiemetics have been studied for the prevention and treatment of PONV following thyroidectomy. These drugs include butyrophenones (e.g., droperidol), benzamides (e.g., metoclopramide), antihistamines (e.g., dimenhydrinate), corticosteroids (e.g., dexamethasone), propofol, oxygen, and serotonon receptor antagonists (e.g., ondansetron). Most of published trials indicate improved prophylaxis against PONV by avoiding risk factors and/or by using effective antiemetic therapy in patients scheduled for thyroid surgery. Traditional antiemetics (droperidol, metoclopramide, and alizapride), non-traditional antiemetics (propofol and dexamethasone), and serotonin receptor antagonists (ondansetron, granisetron, tropisetron, dolasetron, and ramosetron) have been studied for the prevention of PONV.
3.Development and validation of a stability-indicating HPLC-UV method for the determination of alizapride and its degradation products.
Tamaro I1, Aprile S, Giovenzana GB, Grosa G. J Pharm Biomed Anal. 2010 Apr 6;51(5):1024-31. doi: 10.1016/j.jpba.2009.10.026. Epub 2009 Nov 6.
A stability-indicating high-performance liquid chromatography procedure has been developed for the determination of alizapride (AL) and its main degradation products alizapride carboxylic acid (AL-CA) and alizapride N-oxide (AL-NO2) in drug substance and product. The method was developed based on forced degradation data obtained by HPLC-MS analysis. Indeed AL underwent chemical degradation by acid/base catalyzed hydrolysis and oxidation the main degradation products being AL-CA and AL-NO2 respectively. The separation and quantisation were achieved on a 150-mm reverse phase column with a hydrophilic linkage between silica particles and hydrophobic alkyl chains. The mobile phase was constituted (flow rate 1.5mLmin(-1)) of eluant A: aqueous acetate buffer (pH 4.0; 20mM) and eluant B: CH(3)OH using a gradient elution and detection of analytes at 225nm. The method showed good linearity for the AL, AL-CA, AL-NO2 mixture in the 25-75, 1-15 and 1-15microgmL(-1) ranges respectively, being all the square of the correlation coefficients greater than 0.
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CAS 59338-93-1 Alizapride

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