Alizapride - CAS 59338-93-1
Catalog number: 59338-93-1
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
Molecular Weight:
Dopamine Receptor
Alizapride is a dopamine antagonist. It has prokinetic and antiemetic effects and is used in the treatment of nausea and vomiting, including postoperative nausea and vomiting. It is structurally related to metoclopramide and other benzamides. It has been listed.
Solid powder
Soluble in DMSO, not in water
-20°C Freezer
Alizapride has prokinetic and antiemetic effects and is used in the treatment of nausea and vomiting, including postoperative nausea and vomiting.
Quality Standard:
In-house standard
Grams to Kilograms
Boiling Point:
580.3±40.0 °C | Condition: Press: 760 Torr
Melting Point:
139 °C
1.224±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
Canonical SMILES:
Current Developer:
Alizapride has been listed.
1.Study of the prophylactic effect of droperidol, alizapride, propofol and promethazine on spinal morphine-induced pruritus.
Horta ML1, Morejon LC, da Cruz AW, Dos Santos GR, Welling LC, Terhorst L, Costa RC, Alam RU. Br J Anaesth. 2006 Jun;96(6):796-800. Epub 2006 Apr 5.
BACKGROUND: We have compared the use of alizapride, propofol, droperidol and promethazine for the prevention of spinal morphine-induced pruritus.
2.The benefits and risks of different therapies in preventing postoperative nausea and vomiting in patients undergoing thyroid surgery.
Fujii Y1. Curr Drug Saf. 2008 Jan;3(1):27-34.
Postoperative nausea and vomiting (PONV) are distressing and frequent adverse events of anesthesia and surgery, with a relatively high incidence following thyroidectomy. These symptoms predispose to aspiration of gastric contents, increased intraocular pressure, psychological distress, and delayed recovery and discharge times. Numerous antiemetics have been studied for the prevention and treatment of PONV following thyroidectomy. These drugs include butyrophenones (e.g., droperidol), benzamides (e.g., metoclopramide), antihistamines (e.g., dimenhydrinate), corticosteroids (e.g., dexamethasone), propofol, oxygen, and serotonon receptor antagonists (e.g., ondansetron). Most of published trials indicate improved prophylaxis against PONV by avoiding risk factors and/or by using effective antiemetic therapy in patients scheduled for thyroid surgery. Traditional antiemetics (droperidol, metoclopramide, and alizapride), non-traditional antiemetics (propofol and dexamethasone), and serotonin receptor antagonists (ondansetron, granisetron, tropisetron, dolasetron, and ramosetron) have been studied for the prevention of PONV.
3.Development and validation of a stability-indicating HPLC-UV method for the determination of alizapride and its degradation products.
Tamaro I1, Aprile S, Giovenzana GB, Grosa G. J Pharm Biomed Anal. 2010 Apr 6;51(5):1024-31. doi: 10.1016/j.jpba.2009.10.026. Epub 2009 Nov 6.
A stability-indicating high-performance liquid chromatography procedure has been developed for the determination of alizapride (AL) and its main degradation products alizapride carboxylic acid (AL-CA) and alizapride N-oxide (AL-NO2) in drug substance and product. The method was developed based on forced degradation data obtained by HPLC-MS analysis. Indeed AL underwent chemical degradation by acid/base catalyzed hydrolysis and oxidation the main degradation products being AL-CA and AL-NO2 respectively. The separation and quantisation were achieved on a 150-mm reverse phase column with a hydrophilic linkage between silica particles and hydrophobic alkyl chains. The mobile phase was constituted (flow rate 1.5mLmin(-1)) of eluant A: aqueous acetate buffer (pH 4.0; 20mM) and eluant B: CH(3)OH using a gradient elution and detection of analytes at 225nm. The method showed good linearity for the AL, AL-CA, AL-NO2 mixture in the 25-75, 1-15 and 1-15microgmL(-1) ranges respectively, being all the square of the correlation coefficients greater than 0.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Dopamine Receptor Products

CAS 189744-46-5 RO10-5824

(CAS: 189744-46-5)

RO10-5824 is a D4-selective partial agonist (EC50 = 205 nM) that binds with high affinity (Ki = 5.2 nM), and is approximately 250-fold selectivity over D3 recep...

CAS 85798-08-9 (-)-Quinpirole hydrochloride

(-)-Quinpirole hydrochloride
(CAS: 85798-08-9)

(-)-Quinpirole hydrochloride is a selective dopamine D2 receptor agonist, with high affinity for the D2 and D3 dopamine receptor subtypes (Ki values are 4.8, ~2...

CAS 67287-39-2 SKF 81297 hydrobromide

SKF 81297 hydrobromide
(CAS: 67287-39-2)

SKF 81297 hydrobromide is a selective dopamine D1-like receptor agonist.

CAS 159795-62-7 (S)-PPHT hydrochloride

(S)-PPHT hydrochloride
(CAS: 159795-62-7)

(S)-PPHT hydrochloride is a potent and selective D2 agonist.

CAS 2022-29-9 Spiperone hydrochloride

Spiperone hydrochloride
(CAS: 2022-29-9)

Spiperone hydrochloride is a 5-HT2A and selective dopamine D2 receptor antagonist (Ki = 0.06, 0.6, 0.08, ~ 350, ~ 3500 nM for D2, D3, D4, D1 and D5 receptors, r...

CAS 81409-90-7 Cabergoline

(CAS: 81409-90-7)

Cabergoline is a lysergic acid amide derivative and a potent dopamine D2 receptor agonist. It has been used for monotherapy of Parkinson′s disease in the early ...

CAS 346688-38-8 Pridopidine

(CAS: 346688-38-8)

Pridopidine, also known as ACR16, is a dopamine stabilizer used in the treatment of neurologic and psychiatric disorders.

CAS 28094-15-7 Oxidopamine hydrochloride

Oxidopamine hydrochloride
(CAS: 28094-15-7)

Oxidopamine hydrochloride, also called as 6-OHDA, is a selective catecholaminergic neurotoxin that selectively destroy dopaminergic and noradrenergic neurons in...

Chemical Structure

CAS 59338-93-1 Alizapride

Quick Inquiry

Verification code

Featured Items