Alibendol - CAS 26750-81-2
Catalog number: 26750-81-2
Category: Inhibitor
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Molecular Formula:
Molecular Weight:
Alibendol is an antispasmodic,choleretic, and cholekinetic.
EB 1856
Canonical SMILES:
1. A sensitive, acetonitrile-free, HPLC method for determination of alibendol in dog plasma and its application to pharmacokinetic studies
Jae Kuk Ryu. Journal of Pharmaceutical Investigation (2012) 42:185–190
Alibendol, or 5-allyl-2-hydroxy-N-(2-hydroxyethyl)-3-methoxybenzamide, is known as an active pharmaceutical ingredient in antispasmodic, choleretic, and cholekinetic medications. This drug is useful for the treatment of dyspepsia due to biliary insufficiency, alimentary intolerance,and constipation of hepatic origin (Kim et al. 2004; Song et al. 2010). To date, only one method to assess alibendol levels in plasma has been reported in the literature (Song et al. 2010). However, this method uses acetonitrile as a mobile phase. Because acetonitrile is obtained as a co-product in the production of acrylonitrile, many industries are experiencing a shortage of acetonitrile (Venkatasami and Sowa 2010). This ongoing acetonitrile shortage has forced chemists to replace acetonitrile with more readily available solvents, such as methanol. To date, this is the first report of an acetonitrile-free high performance liquid chromatography (HPLC) method for the determination of alibendol in biological fluids. The method previously reported by Song et al. (2010) achieved an LLOQ of 50 ng/ml. Thus, that method may lack the sensitivity needed to determine the low plasma concentrations encountered in pharmaco- kinetic studies. Furthermore, that report is written in Korean, so it may be difficult for non-Koreans to use that method.
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CAS 26750-81-2 Alibendol

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