Alfacalcidol - CAS 41294-56-8
Catalog number: B0084-068405
Category: Inhibitor
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Molecular Formula:
C27H44O2
Molecular Weight:
400.65
COA:
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Targets:
VD/VDR
Description:
A synthetic analog of Calcitiol (the hormonal form of vitamin D3), which shows identical potency with respect to stimulation of intestinal calcium absorption and bone mineral mobilization. Vitamin D source.
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-068405 50 mg $398 In stock
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Brife Description:
active metabolite of Vitamin D
Purity:
>98%
Appearance:
White to Off-White Solid
Synonyms:
1-Hydroxycholecalciferol; Alfarol; EinsAlpha; Alpha-Calcidol; One-Alpha; (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
MSDS:
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Shelf Life:
2 years
Melting Point:
>121 °C (dec.)
InChIKey:
OFHCOWSQAMBJIW-AVJTYSNKSA-N
InChI:
InChI=1S/C27H44O2/c1-18(2)8-6-9-19(3)24-13-14-25-21(10-7-15-27(24,25)5)11-12-22-16-23(28)17-26(29)20(22)4/h11-12,18-19,23-26,28-29H,4,6-10,13-17H2,1-3,5H3/b21-11+,22-12-/t19-,23-,24-,25+,26+,27-/m1/s1
Canonical SMILES:
CC(C)CCCC(C)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C
1.High Serum Sclerostin Levels Are Associated with a Better Outcome in Haemodialysis Patients.
Jean G1, Chazot C, Bresson E, Zaoui E, Cavalier E. Nephron. 2016;132(3):181-90. doi: 10.1159/000443845. Epub 2016 Feb 19.
BACKGROUND: Sclerostin is an osteocyte hormone that decreases osteoblastogenesis. Sclerostin may play a key role in osteoporosis and also in vascular calcification (VC). In chronic kidney disease and haemodialysis (HD) patients, serum sclerostin levels are high.
2.Use of off-label nephrology-related drugs in hospitalized pediatric patients: a retrospective study.
Yasinta M1,2, Che RC1,2, Hu CY1,2, Du XH1,2, Ding GX1,2, Huang SM1,2, Chen Y3,4,5, Zhang AH1,2. World J Pediatr. 2016 May;12(2):236-42. doi: 10.1007/s12519-015-0058-7. Epub 2015 Dec 18.
BACKGROUND: The information about the use of off-label drugs in pediatric nephrology is still lacking, which leads to increased adverse reactions and medical disputes. We retrospectively analyzed the use of off-label drugs in the in-patient ward of the nephrology department of Nanjing Children's Hospital, China in order to provide more complete information about the use of drugs for children.
3.Effects of 1α-Calcidol (Alfacalcidol) on Microvascular Endothelial Function, Arterial Stiffness, and Blood Pressure in Type II Diabetic Nephropathy Patients.
Munisamy S1, Daud KM2, Mokhtar SS1, Rasool AH1. Microcirculation. 2016 Jan;23(1):53-61. doi: 10.1111/micc.12256.
OBJECTIVES: To determine the effects of six months alfacalcidol on microvascular endothelial function, arterial stiffness, and BP in DN patients.
4.Prevalence and treatment of hypovitaminosis D in the haemodialysis population of Coventry.
Huish SA1, Fletcher S2, Dunn JA3, Hewison M4, Bland R5. J Steroid Biochem Mol Biol. 2016 Feb 11. pii: S0960-0760(16)30023-1. doi: 10.1016/j.jsbmb.2016.02.009. [Epub ahead of print]
Low serum 25(OH)D and associated bone and non-bone related problems are not well appreciated in end stage renal disease (ESRD). Vitamin D treatment strategies in the UK currently focus almost exclusively on calcitriol [1,25(OH)2D], alfacalcidol or paricalcitol. In ESRD hypovitaminosis D is associated with bone loss, muscle weakness, falls, fractures and increased inflammation. National guidelines changed in 2014 and now recommend the diagnosis and treatment of low serum 25(OH)D in all patients with glomerular filtration rate (GFR) less than 30ml/min/1.73m2. However as yet there are no standardized guidelines for dosage, frequency and monitoring in ESRD patients. Following a systematic review of the literature we developed a clinical guideline for cholecalciferol supplementation at University Hospitals of Coventry and Warwickshire, UK. The guideline recommends 40,000IU cholecalciferol weekly for patients with 25(OH)D <50nmol/L and 20,000IU weekly for patients with 25(OH)D 50-75nmol/L; to be continued long term unless levels increase to ≥150nmol/L.
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Chemical Structure

CAS 41294-56-8 Alfacalcidol

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