Alfacalcidol - CAS 41294-56-8
Catalog number:
B0084-068405
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C27H44O2
Molecular Weight:
400.65
COA:
Inquire
Targets:
VD/VDR
Description:
A synthetic analog of Calcitiol (the hormonal form of vitamin D3), which shows identical potency with respect to stimulation of intestinal calcium absorption and bone mineral mobilization. Vitamin D source.
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-068405 50 mg $398 In stock
Bulk Inquiry
Publictions citing BOC Sciences Products
  • >> More
Brife Description:
active metabolite of Vitamin D
Purity:
>98%
Appearance:
White to Off-White Solid
Synonyms:
1-Hydroxycholecalciferol; Alfarol; EinsAlpha; Alpha-Calcidol; One-Alpha; (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
MSDS:
Inquire
Shelf Life:
2 years
Melting Point:
>121 °C (dec.)
InChIKey:
OFHCOWSQAMBJIW-AVJTYSNKSA-N
InChI:
InChI=1S/C27H44O2/c1-18(2)8-6-9-19(3)24-13-14-25-21(10-7-15-27(24,25)5)11-12-22-16-23(28)17-26(29)20(22)4/h11-12,18-19,23-26,28-29H,4,6-10,13-17H2,1-3,5H3/b21-11+,22-12-/t19-,23-,24-,25+,26+,27-/m1/s1
Canonical SMILES:
CC(C)CCCC(C)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C
1.High Serum Sclerostin Levels Are Associated with a Better Outcome in Haemodialysis Patients.
Jean G1, Chazot C, Bresson E, Zaoui E, Cavalier E. Nephron. 2016;132(3):181-90. doi: 10.1159/000443845. Epub 2016 Feb 19.
BACKGROUND: Sclerostin is an osteocyte hormone that decreases osteoblastogenesis. Sclerostin may play a key role in osteoporosis and also in vascular calcification (VC). In chronic kidney disease and haemodialysis (HD) patients, serum sclerostin levels are high.
2.Use of off-label nephrology-related drugs in hospitalized pediatric patients: a retrospective study.
Yasinta M1,2, Che RC1,2, Hu CY1,2, Du XH1,2, Ding GX1,2, Huang SM1,2, Chen Y3,4,5, Zhang AH1,2. World J Pediatr. 2016 May;12(2):236-42. doi: 10.1007/s12519-015-0058-7. Epub 2015 Dec 18.
BACKGROUND: The information about the use of off-label drugs in pediatric nephrology is still lacking, which leads to increased adverse reactions and medical disputes. We retrospectively analyzed the use of off-label drugs in the in-patient ward of the nephrology department of Nanjing Children's Hospital, China in order to provide more complete information about the use of drugs for children.
3.Effects of 1α-Calcidol (Alfacalcidol) on Microvascular Endothelial Function, Arterial Stiffness, and Blood Pressure in Type II Diabetic Nephropathy Patients.
Munisamy S1, Daud KM2, Mokhtar SS1, Rasool AH1. Microcirculation. 2016 Jan;23(1):53-61. doi: 10.1111/micc.12256.
OBJECTIVES: To determine the effects of six months alfacalcidol on microvascular endothelial function, arterial stiffness, and BP in DN patients.
4.Prevalence and treatment of hypovitaminosis D in the haemodialysis population of Coventry.
Huish SA1, Fletcher S2, Dunn JA3, Hewison M4, Bland R5. J Steroid Biochem Mol Biol. 2016 Feb 11. pii: S0960-0760(16)30023-1. doi: 10.1016/j.jsbmb.2016.02.009. [Epub ahead of print]
Low serum 25(OH)D and associated bone and non-bone related problems are not well appreciated in end stage renal disease (ESRD). Vitamin D treatment strategies in the UK currently focus almost exclusively on calcitriol [1,25(OH)2D], alfacalcidol or paricalcitol. In ESRD hypovitaminosis D is associated with bone loss, muscle weakness, falls, fractures and increased inflammation. National guidelines changed in 2014 and now recommend the diagnosis and treatment of low serum 25(OH)D in all patients with glomerular filtration rate (GFR) less than 30ml/min/1.73m2. However as yet there are no standardized guidelines for dosage, frequency and monitoring in ESRD patients. Following a systematic review of the literature we developed a clinical guideline for cholecalciferol supplementation at University Hospitals of Coventry and Warwickshire, UK. The guideline recommends 40,000IU cholecalciferol weekly for patients with 25(OH)D <50nmol/L and 20,000IU weekly for patients with 25(OH)D 50-75nmol/L; to be continued long term unless levels increase to ≥150nmol/L.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related VD/VDR Products


CAS 103656-40-2 Calcitriol Impurities D

Calcitriol Impurities D
(CAS: 103656-40-2)

One of the impurities of Calcitriol, an active metabolite of VD3, could be a agonist of vitamin D receptor.

CAS 67-97-0 Cholecalciferol

Cholecalciferol
(CAS: 67-97-0)

Cholecalciferol is a naturally occuring form of vitamin D which is obtained from dietary sources, such as fish, or through the conversion of 7-dehydrocholestero...

CAS 66791-71-7 Impurity B of Calcitriol

Impurity B of Calcitriol
(CAS: 66791-71-7)

Impurity B of Calcitriol is the hormonally active form of vitamin D, and Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor...

CAS 54573-75-0 Doxercalciferol

Doxercalciferol
(CAS: 54573-75-0)

Doxercalciferol (Hectorol; 1.alpha.-Hydroxyvitamin D2) is a synthetic analog of vitamin D; is a Vitamin D2 analog that acts as a vitamin D receptor activator (V...

CAS 72203-93-1 Calcitetrol

Calcitetrol
(CAS: 72203-93-1)

Calcitetrol is the hormonally active form of vitamin D with three hydroxyl groups. It increases blood calcium levels ([Ca2+]) by promoting absorption of dietary...

CAS 19356-17-3 Calcifediol

Calcifediol
(CAS: 19356-17-3)

Calcifediol is a major circulating metabolite of vitamin D3 and acts as a competitive inhibitor with an apparent Ki of 3.9 μM. It also suppresses PTH secretion ...

CAS 104121-92-8 Eldecalcitol

Eldecalcitol
(CAS: 104121-92-8)

Eldecalcitol, a vitamin D analog, has strong effects to reduce calcium reabsorption into the body from bones, therefore increasing bone mineral density, and to ...

CAS 40013-87-4 24, 25-Dihydroxy VD3

24, 25-Dihydroxy VD3
(CAS: 40013-87-4)

24, 25-Dihydroxy VD3 is a compound which is closely related to 1,25-dihydroxyvitamin D3, the active form of vitamin D3, but like vitamin D3 itself and 25-hydrox...

CAS 511-28-4 Vitamin D4

Vitamin D4
(CAS: 511-28-4)

Vitamin D4 is the active analogue of Vitamin D.

CAS 103909-75-7 Maxacalcitol

Maxacalcitol
(CAS: 103909-75-7)

Maxacalcitol is non-calcemic vitamin D3 analog and ligand of VDR-like receptors.

CAS 134404-52-7 Seocalcitol

Seocalcitol
(CAS: 134404-52-7)

Seocalcitol is a vitamin D receptor (VDR) agonist. Seocalcitol exhibits anti-tumor and anti-proliferative activity with reduced hypercalcemic effects

CAS 112828-09-8 (24R)-MC 976

(24R)-MC 976
(CAS: 112828-09-8)

(24R)-MC 976 is a Vitamin D3 derivative.

CAS 131875-08-6 Lexacalcitol

Lexacalcitol
(CAS: 131875-08-6)

KH1060 metabolism could be blocked by the cytochrome P450 inhibitor, ketoconazole. KH1060 was not an effective competitor of C24 oxidation of 1alpha,25-(OH)2D3....

CAS 58050-55-8 24, 25-Dihydroxy VD2

24, 25-Dihydroxy VD2
(CAS: 58050-55-8)

24, 25-Dihydroxy VD2 is a hydroxylated metabolite of Vitamin D2, which is a synthetic analog of Vitamin D.

CAS 60133-18-8 Ercalcitriol

Ercalcitriol
(CAS: 60133-18-8)

Ercalcitriol is a active metabolite of vitamin D2. It exhibits equipotent antirachitic activity in rats as calcitriol.

CAS 112875-61-3 Impurity of Calcipotriol

Impurity of Calcipotriol
(CAS: 112875-61-3)

Impurity of Calcipotriol; Calcipotriol (MC 903; Calcipotriene) is a ligand of VDR-like receptors.

CAS 113082-99-8 Calcipotriol Impurity C

Calcipotriol Impurity C
(CAS: 113082-99-8)

Calcipotriol Impurity C, the trans-isomeric impurity of Calcipotriene, is an analogue of VD3 which could be an agonist of vitamin D receptor.

CAS 112965-21-6 Calcipotriol

Calcipotriol
(CAS: 112965-21-6)

Calcipotriol, a 1,25-Dihydroxyvitamin D3 analogue, is used as topical treatment for psoriasis.

CAS 55721-11-4 Secalciferol

Secalciferol
(CAS: 55721-11-4)

Secalciferol is a metabolite of Vitamin D, a possibly anti-inflammatory steroid which is involved in bone ossification. lt mediates calcium and phosphorus homeo...

CAS 86307-44-0 Impurity C of Calcitriol

Impurity C of Calcitriol
(CAS: 86307-44-0)

Impurity C of Calcitriol is the impurity C of Calcitriol, which is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR).

Chemical Structure

CAS 41294-56-8 Alfacalcidol

Quick Inquiry

Verification code

Featured Items