Alendronate sodium - CAS 129318-43-0
Category: APIs
Molecular Formula:
C4H12NNaO7P2
Molecular Weight:
271.077
COA:
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Description:
Alendronate sodium is a medication used for the treatment of postmenopausal osteoporosis that strengthens bones.
Synonyms:
Fosamax; Fosamac; Onclast; Binosto; Osteovan
MSDS:
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InChIKey:
CAKRAHQRJGUPIG-UHFFFAOYSA-M
InChI:
InChI=1S/C4H13NO7P2.Na/c5-3-1-2-4(6,13(7,8)9)14(10,11)12;/h6H,1-3,5H2,(H2,7,8,9)(H2,10,11,12);/q;+1/p-1
Canonical SMILES:
C(CC(O)(P(=O)(O)O)P(=O)(O)[O-])CN.[Na+]
1.Effectiveness of bisphosphonate use and risk of contralateral breast cancer and recurrence in women with early-stage breast cancer treated with tamoxifen.
Kwan ML1, Shi JM2, Habel LA3, Song J4, Chung JW2, Avila CC2, Schottinger JE5, Cheetham TC2, Fletcher SW6, Haque R2. Breast Cancer Res Treat. 2016 Apr;156(2):379-89. doi: 10.1007/s10549-016-3763-6. Epub 2016 Mar 22.
The effectiveness of bisphosphonates (BP) in reducing risk of second breast cancer and recurrence in observational studies has been minimally studied. We examined the association of oral BP use on risk of contralateral breast cancer (CBC) and recurrence in 16,781 women diagnosed with early-stage breast cancer from 1996 to 2007, treated with tamoxifen, and followed through December 31, 2009 at Kaiser Permanente Northern California (KPNC, n = 8857) and Southern California (KPSC, n = 7924). Sociodemographic, clinical, and pharmacy information were extracted from electronic medical records and cancer registries. CBC was identified from cancer registries, and recurrences from electronic health records and chart reviews. Multivariate Cox regression models were used to estimate hazard ratios (HR) and 95 % confidence intervals (CI) treating BP use and hormonal therapy as time-varying variables. After mean 6.4 years of follow-up, 494 (3.0 %) women developed CBC.
2.NF-κB pathway inhibition by anthrocyclic glycoside aloin is key event in preventing osteoclastogenesis in RAW264.7 cells.
Pengjam Y1, Madhyastha H2, Madhyastha R2, Yamaguchi Y2, Nakajima Y2, Maruyama M3. Phytomedicine. 2016 Apr 15;23(4):417-28. doi: 10.1016/j.phymed.2016.01.006. Epub 2016 Feb 15.
BACKGROUND: Osteoporosis is a bone pathology leading to increased fracture risk and challenging the quality of life. As current treatments can exhibit deleterious side effects, the use of phyto-compounds with therapeutic and preventive activities against orthopaedic related problems represents a promising alternative.
3.Cost-Effectiveness of Intervention Thresholds for the Treatment of Osteoporosis Based on FRAX® in Portugal.
Marques A1,2, Lourenço Ó3, Ortsäter G4, Borgström F4, Kanis JA5, da Silva JA6,7. Calcif Tissue Int. 2016 Mar 25. [Epub ahead of print]
Cost-effective intervention thresholds (ITs) based on FRAX® were determined for Portugal. Assuming a willingness to pay (WTP) of €32,000 per quality-adjusted life years (QALYs), treatment with generic alendronate is cost effective for men and women aged 50 years or more, with 10-year probabilities for major osteoporotic fractures and hip above 8.8 and 2.5 %, respectively. The aim of the present study was to identify the 10-year probabilities of a major and hip osteoporotic fracture using FRAX® validated for Portugal, above which pharmacologic interventions become cost effective in the Portuguese context. A previously developed and validated state transition Markov cohort model was populated with epidemiologic, economic and quality-of-life fracture data from Portugal. Cost-effectiveness of FRAX®-based ITs was calculated for generic alendronate and proprietary zoledronic acid, denosumab and teriparatide were compared to "no intervention", assuming a WTP of €32,000 (two times national Gross Domestic Product per capita) per QALYs.
4.Effects of Bisphosphonates and Calcium plus Vitamin-D Supplements on Cognitive Function in Postmenopausal Osteoporosis.
Safer U1, Safer VB2, Demir SO3, Yanikoglu I3. Endocr Metab Immune Disord Drug Targets. 2016 Mar 29. [Epub ahead of print]
BACKGROUND: Postmenopausal osteoporosis has been linked to accelerated cognitive decline; however, little is known about the effects of medical treatment on cognitive functions.
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CAS 129318-43-0 Alendronate sodium

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