Aldioxa - CAS 5579-81-7
Catalog number: B0046-071609
Category: APIs
Molecular Formula:
C4H9AlN4O5
Molecular Weight:
220.121
COA:
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Description:
Aldioxa is a gastrointestinal agent that improves delayed gastric emptying.
Ordering Information
Catalog Number Size Price Stock Quantity
B0046-071609 10 g $198 In stock
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Appearance:
Solid Powder
Synonyms:
Isalon; Dihydroxyaluminum allantoinate; Chlokale; Peptilate; Ascomp; [4-(carbamoylamino)-5-oxo-1,4-dihydroimidazol-2-yl]oxyaluminum dihydrate
MSDS:
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InChIKey:
AMZWNNKNOQSBOP-UHFFFAOYSA-M
InChI:
InChI=1S/C4H6N4O3.Al.2H2O/c5-3(10)6-1-2(9)8-4(11)7-1;;;/h1H,(H3,5,6,10)(H2,7,8,9,11);;2*1H2/q;+1;;/p-1
Canonical SMILES:
C1(C(=O)NC(=N1)O[Al])NC(=O)N.O.O
1.[Acidified aspirin-induced gastric lesion in rats with hepatic cirrhosis produced by N-nitrosodiethylamine or carbon tetrachloride. Effect of aldioxa on gastric lesions].
Uchida M1, Hamura H, Takagi S, Noguchi Y, Shibata H, Honda H. Nihon Yakurigaku Zasshi. 1994 Mar;103(3):111-20.
Gastric lesion was induced by the oral administration of acidified aspirin in rats with hepatic cirrhosis produced by N-nitrosodiethylamine (NDA) or carbon tetrachloride (CCl4). Gastric lesion by acidified aspirin was aggravated in NDA-induced cirrhosis, but not in CCl4-cirrhotic rats. To clarify this difference in the susceptibility of the gastric mucosa, gastric mucosal blood flow and gastric emptying were measured by the hydrogen gas clearance method and beads method, respectively. Gastric mucosal blood flow was lower and gastric emptying was significantly delayed in NDA-induced cirrhotic rats as compared with the controls, but not in CCl4-induced cirrhotic rats. Gastric mucosal blood flow in NDA-induced cirrhotic rats was significantly decreased by the oral administration of acidified aspirin as compared with the controls. Aldioxa dose-dependently inhibited the gastric lesion formation by acidified aspirin and inhibited the decrease of gastric mucosal blood flow in NDA-induced cirrhotic rats.
2.Anticalculus efficacy of a new dentifrice.
Llena C1, Forner L, Vento C. Quintessence Int. 2009 Jun;40(6):497-501.
OBJECTIVE: The Volpe and Manhold Index (VMI) was used to evaluate the anticalculus efficacy of the dentifrice Fluor Kin antisarro, used on adults twice a day for 2 minutes over 3 months, in comparison with the dentifrice Lacer.
3.[Effect of anti-ulcer drugs and PGE2 on the proliferation of rat gastric cultured cells].
Uchida M1, Nishimura N, Misaki N, Ikarashi Y, Kobayashi M, Kawano O. Nihon Yakurigaku Zasshi. 1990 Apr;95(4):185-90.
The effects of anti-ulcer drugs and PGE2 on the proliferation of rat gastric cultured cells were investigated. To study the cell proliferation, the rate of incorporation of 3H-thymidine into the cultured cells was measured. ULTROSER G, corresponding to fetal bovine serum, was found to dose-dependently increase the incorporation of 3H-thymidine into the cultured cells at a dose range of 1-4%. The incorporation of 3H-thymidine was highest at 36 hr after the inoculation of cells. Therefore, the effect of the drugs on the proliferation was performed under the condition of 2% ULTROSER G and evaluated at 36 hr. Aldioxa, cetraxate HCl, cimetidine (10(-7)-10(-5) M) and PGE2 (10(-8)-10(-6) M) had no effect on the cell proliferation, while indomethacin (0.35-1.41 x 10(-3) M) inhibited the proliferation in a dose-dependent manner. Aldioxa, cetraxate HCl (10(-5) M) and PGE2 (10(-6), 10(-8) M) antagonized the inhibitory effect by indomethacin at a concentration of 0.
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CAS 5579-81-7 Aldioxa

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