Albendazole Oxide - CAS 54029-12-8
Catalog number: 54029-12-8
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C12H15N3O3S
Molecular Weight:
281.33
COA:
Inquire
Description:
Albendazole Oxide is a tubulin polymerization or assembly inhibitor.
Purity:
>98%
Synonyms:
Ricobendazole
MSDS:
Inquire
InChIKey:
VXTGHWHFYNYFFV-UHFFFAOYSA-N
InChI:
InChI=1S/C12H15N3O3S/c1-3-6-19(17)8-4-5-9-10(7-8)14-11(13-9)15-12(16)18-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16)
Canonical SMILES:
CCCS(=O)C1=CC2=C(C=C1)N=C(N2)NC(=O)OC
1.In vitro culture of Echinococcus multilocularis: protoscolicidal action of praziquantel and albendazole sulphoxide.
Taylor DH;Morris DL Trans R Soc Trop Med Hyg. 1988;82(2):265-7.
The metacestode stage of Echinococcus multilocularis was cultured in vitro. Sensitivity of protoscoleces to the presence of albendazole sulphoxide, praziquantel and methanol was assessed. 10 micrograms/litre of praziquantel or 500 micrograms/litre of albendazole sulphoxide significantly reduced protoscolex viability. The presence of methanol (at 0.25%) had no significant effect. In vitro culture of E. multilocularis can be used to assess possible chemotherapeutic agents.
2.Pharmacokinetic investigation of albendazole and praziquantel in Thai children infected with Giardia intestinalis.
Pengsaa K;Na-Bangchang K;Limkittikul K;Kabkaew K;Lapphra K;Sirivichayakul C;Wisetsing P;Pojjaroen-Anant C;Chanthavanich P;Subchareon A Ann Trop Med Parasitol. 2004 Jun;98(4):349-57.
The pharmacokinetics of albendazole/albendazole sulphoxide and praziquantel were investigated in Thai children with Giardia infection. Twenty school-age children were randomly allocated to receive either a single oral dose of albendazole (400 mg/child) or the same dose of albendazole given concurrently with a single oral dose of praziquantel (20 mg/kg). The concentrations of albendazole/albendazole sulphoxide and praziquantel in plasma samples, collected at intervals in the first 24 h post-treatment, were then quantified using HPLC with ultra-violet detection. No significant pharmacokinetic interaction between the albendazole and praziquantel was demonstrated. For albendazole sulphoxide, the active metabolite of albendazole, there was marked inter-individual variation in the maximum plasma concentration and the 'area under the curve'. The pharmacokinetics of albendazole sulphoxide were similar whether albendazole was given alone or in combination with praziquantel.
3.Enantiomeric separation of chiral sulfoxides by supercritical fluid chromatography.
Toribio L;Alonso C;del Nozal MJ;Bernal JL;Jiménez JJ J Sep Sci. 2006 Jul;29(10):1363-72.
The application of supercritical fluid chromatography (SFC) to the enantiomeric separation of several chiral sulfoxides belonging to the family of the substituted benzimidazoles, including omeprazole, lansoprazole, pantoprazole, rabeprazole, oxfendazole and ricobendazole, is presented in this work. The column employed was Chiralpak AD and the effect of different chromatographic conditions was studied. The results obtained showed that all the compounds can be enantiomerically resolved using SFC, with resolutions higher than 2 and analysis times that in most cases were lower than 10 min. Alcohol type modifiers provided the best results, with ricobendazole, oxfendazole, and omeprazole showing the highest retentions and resolutions. Study of the temperature effect revealed that, in general, the isoelution temperature was above the temperatures assayed, except in the cases of omeprazole, lansoprazole, and oxfendazole with ethanol as modifier and pantoprazole with acetonitrile. Enthalpy-entropy compensation could also be demonstrated for the retention of the first and second eluted enantiomers as well as for the selectivity, with compensation temperatures of 25 degrees C, 45 degrees C, and 83 degrees C, respectively.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products


CAS 405225-21-0 NFPS

NFPS
(CAS: 405225-21-0)

NFPS is a non-transportable GlyT1 inhibitor.

CAS 221529-58-4 RO1138452

RO1138452
(CAS: 221529-58-4)

RO1138452 is one of the most potent high-affinity ligands and functional antagonists for the human IP (prostacyclin) receptor. It exhibits no affinity at other ...

CAS 153034-77-6 LY 292728

LY 292728
(CAS: 153034-77-6)

LY 292728, an oxoxanthene derivative, has been found to be a leukotriene B4 receptor antagonist that has once been studied as an antiasthmatic agent.

CAS 68637-19-4 Aluminum phthalocyanine disulfonate

Aluminum phthalocyanine disulfonate
(CAS: 68637-19-4)

Aluminum phthalocyanine disulfonate sodium, also known as AlPcS2 disodium or AlS2Pc or AlPcS(2a), is a potent photosensitizer, and is potentially useful in canc...

CAS 169209-63-6 (2R,4R)-APDC

(2R,4R)-APDC
(CAS: 169209-63-6)

(2R,4R)-APDC is a selective and relatively potent group II mGluR agonist (EC50 = 0.4, 0.4, > 100, > 100, > 300 and > 300 μM for human mGlu2, mGlu3, mGlu1, mGlu5...

CAS 137-88-2 Amprolium hydrochloride

Amprolium hydrochloride
(CAS: 137-88-2)

Amprolium chloride is a thiamin antagonist, which prevents carbohydrate synthesis by blocking thiamine uptake.

CAS 380560-89-4 DQP 1105

DQP 1105
(CAS: 380560-89-4)

DQP 1105 has been found to be a NMDA receptor antagonist and could exhibit potential activities in the treatment of neurological disability.

CAS 882737-42-0 ACR 16 hydrochloride

ACR 16 hydrochloride
(CAS: 882737-42-0)

ACR 16 hydrochloride is a dopaminergic stabilizer (Ki values 17550 nM and 7521 for D2(low) and D2(high), respectively) that state-dependently stabilizes psychom...

Chemical Structure

CAS 54029-12-8 Albendazole Oxide

Quick Inquiry

Verification code

Featured Items