|Description||Aladorianis is a ryanodine receptor calcium release channel modulator. It is an antiarrhythmic agent. Clinical development for Chronic heart failure and Ventricular tachycardia was discontinued.|
|Synonyms||2,3-Dihydro-7-methoxy-α-oxo-1,4-benzothiazepine-4(5H)-acetic Acid; ARM 036; Aladorian; S 36; S 44121-1|
|Solubility||Soluble in DMSO|
|Application||Chronic heart failure; Ventricular tachycardia|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
|Current Developer||ARMGO Pharma; Servier|
SHP099 is a potent, selective, orally bioavailable, and efficacious SHP2 inhibitor (IC50 value 0.071 μM) that stabilizes SHP2 in an auto-inhibited conformation....
Rehmannioside A is an iridoid glucoside extracted from the roots of Rehmannia glutinosa.
PTP1B-IN-1 is a potent protein tyrosine phosphatase-1B (PTP1B) inhibitor.
Tirasemtiv is a a small-molecule fast-skeletal-troponin activator, which is being developed as a potential treatment for diseases and conditions associated with...
JNJ26483327 is an orally bioavailable multitargeted reversible tyrosine kinase inhibitor. It binds to and inhibits several members of the epidermal growth facto...
Ursolic acid is a natural pentacyclic triterpenoid carboxylic acid. It exerts anti-tumor effects and is an effective compound for cancer prevention and therapy.
BMS-210285 is a synthetic bio-active chemical.
4-Allylcatechol is an intermediate to synthetic safrole and was used in a study performed to evaluate the phenolic content, antioxidant and antimicrobial activi...
RG7800 is a selective Survival of motor neuron 1 protein (SMN1) stimulant and Survival of motor neuron 2 protein (SMN2) modulator originated by Roche. RG7800 sh...
This active moleculr is a Os(II) anticancer drug candidate. It can generate reactive oxygen species and disrupt the redox balance in cancer cells. Using FY26 an...
Oxytocin acetate is a mammalian neurohypophysial hormone. Its actions are mediated by specific, high-affinity oxytocin receptors. Oxytocin is normally produced ...
AVN-944 (VX-944) is an orally available, synthetic small molecule with potential antineoplastic activity. AVN944 inhibits inosine monosphosphate dehydrogenase (...
Gaxilose is a synthetic disaccharide and a substrate of intestinal lactase. It can be applicated in a new noninvasive diagnostic test based on urine or serum me...
Anti-inflammatory agent. MAPK inhibitor. Inhibits p38, ERK and JNK phosphorylation. Inhibits NFκB activation. Shows antitussive, expectorant and anti-inflammato...
This molecular is a biochemical.
Genipin, a compound isolated from Gardenis jasminoides Ellis fruits, is a cell-permeable inhibitor of UCP2 activity. Genipin also exhibits anti-inflammatory and...
CH 402 can inhibit lipid peroxidation.
Oxethazaine, an effective topical anesthetic, could be used to relieve the pain caused by peptic ulcer disease and esophagitis.
Lubabegron is a β3-adrenoreceptor agonist.
Estradiol 3-sulfamate, also known as J 995 or BLE 00084, is a potent, long-acting, and orally active steroid sulfatase inhibitor (IC50= 251 nM, and Ki= 133 nM f...