Akt1 and Akt2-IN-1 - CAS 893422-47-4
Catalog number: 893422-47-4
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Akt1 and Akt2-IN-1 is an allosteric inhibitor of Akt1 and Akt2 with the IC50 of 3.5 nM and 42 nM respectively. It has potent and balanced activity. It is dependent on the PH-domain for Akt inhibition. It is selective for Akt1/2 over Akt3 and is highly selective over other members of the AGC family of kinases in vitro. It has potent inhibitory activity against Akt1 and Akt 2 in vivo in a mouse lung and efficacy in a tumor xenograft model. It has moderate activity in an hERG binding assay and is a substrate for human P-glycoprotein. It also shows good physical properties with a human plasma protein binding.
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Solid powder
DMSO: > 35 mg/mL
-20°C Freezer
Akt1 and Akt2-IN-1 has potent inhibitory activity against Akt1 and Akt 2 and efficacy in a tumor xenograft model.
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
1.285±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
Canonical SMILES:
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CAS 893422-47-4 Akt1 and Akt2-IN-1

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