|Description||AIDA is a selective group I mGluR agonist and could show centrally active following systemic administration in vivo.|
|Purity||≥98% by HPLC|
CDPPB is a positive allosteric modulator of mGlu5 receptor (EC50 = 10 and 20 nM for human and rat receptors, respectively). Study shows that CDPPB has a therape...
DCB is an allosteric ligand for the metabotropic glutamate receptor mGlu5 that displays neutral modulation. It inhibits the modulation of mGlu5 by other alloste...
(1S,3R)-ACPD, an isomer of (±)-trans-ACPD, has been found to be an agonist of mGluRs.
AZD 9272 is a potent, long-acting and selective nervous system penetrant mGlu5 antagonist with IC50 values of 2.6 and 7.6 nM for rat and human receptors, respec...
(2R,4R)-APDC is a selective and relatively potent group II mGluR agonist (EC50 = 0.4, 0.4, > 100, > 100, > 300 and > 300 μM for human mGlu2, mGlu3, mGlu1, mGlu5...
CTEP is a novel, long-acting, orally bioavailable allosteric antagonist of mGlu5 receptor (IC50=2.2 nM), showing >1000-fold selectivity over other mGlu receptor...
(S)-4C3H-PG has been found to be a competitive GluR1 glutamate receptor antagonist as well as metabotropic GluR2/3 glutamate receptor agonist.
Dipraglurant is a mGlu5 receptor negative allosteric modulator. It is currently in phase II for the treatment of dyskinesia in Parkinson's disease.