|Description||AICAR phosphate, is an AMP-activated protein kinase activator, which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disorders such as diabetes. It stimulates glucose uptake and increases the activity of p38 mitogen-activated protein kinases α and β in skeletal muscle tissue, as well as suppressing apoptosis by reducing production of reactive oxygen compounds inside the cell.|
|Synonyms||Acadesine phosphate; AICA Riboside phosphate|
Dorsomorphin has been shown to act as a potent and selective inhibitor of AMPK (AMP-activated protein kinase) (Ki = 109 nM), induced by AICAR and metformin. It ...
ETC-1002 is a novel, first-in-class, orally available, once-daily LDL-C lowering small molecule and is activator of hepatic AMP-activated protein kinase (AMPK)....
SAMS peptide, a synthetic peptide substrate for AMPK based on the sequence around Ser79 on acetyl-CoA carboxylase, is more selective for the kinase than acetyl ...
WZ4003 exhibits a high, specific affinity to the L858R/T790M mutant EGFR, while a significantly reduced cellular IC50 against T790M containing Ba/F3 cells.
Acadesine is a 5-aminoimidazole-4-carboxamide (AICA) riboside, a purine nucleoside analog, and a nucleotide biosynthesis precursor with B cell pro-apoptotic act...
HTH-01-015 is a potent and selective inhibitor of NUAK1 with IC50 of 100 nM, does not significantly inhibit NUAK2 (IC50 of >10 μM).
Imeglimin is the first in a new tetrahydrotriazine-containing class of oral antidiabetic agents, the glimins. It has been shown to act on the liver, muscle and ...
YLF466D activated recombinant human α1β1γ1, α2β1γ1 and rat liver AMPK. It also activated AMPK α-subunit truncations containing an autoinhibitory domain(AID) and...
Chikusetsu saponin IVa
Chikusetsusaponin IVa is a novel AMPK activator could be useful for the treatment of T2DM or other metabolic disorders.
SC-III3 is a scopoletin derivative and has been found to induce the autophagy of hepatoma HepG2 cells so that could be significant in anticancer studies.
AICAR phosphate, is an AMP-activated protein kinase activator, which is used for the treatment of acute lymphoblastic leukemia and may have applications in trea...
Ampkinone, an AMPK activitor, has been found to have potential effect in the treatment of diabete and obesity. IC50: 4.3 uM(EC50).
Imeglimin hydrochloride is the first in a new tetrahydrotriazine-containing class of oral antidiabetic agents, the glimins. It has been shown to act on the live...
ZLN024 is a novel AMPK allosteric activator and activates α1β1γ1 and α2β1γ1 by around 2–2.5 fold. It activated AMPK in L6 myotubes and stimulated glucose uptake...