|Description||AICAR phosphate, is an AMP-activated protein kinase activator, which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disorders such as diabetes. It stimulates glucose uptake and increases the activity of p38 mitogen-activated protein kinases α and β in skeletal muscle tissue, as well as suppressing apoptosis by reducing production of reactive oxygen compounds inside the cell.|
|Synonyms||Acadesine phosphate; AICA Riboside phosphate|
A-769662 is a small molecule thienopyridone that activates AMPK directly in cell-free assays (EC50 = 116 nM) and intact cells by allosterically activating AMPK ...
RSVA 405, an analog of resveratol, can significantly activate AMPK (EC50 = 1 μM) and inhibit acetyl-CoA carboxylase (ACC), one target of AMPK and a key regulato...
AICAR phosphate, is an AMP-activated protein kinase activator, which is used for the treatment of acute lymphoblastic leukemia and may have applications in trea...
Dorsomorphin has been shown to act as a potent and selective inhibitor of AMPK (AMP-activated protein kinase) (Ki = 109 nM), induced by AICAR and metformin. It ...
Ampkinone, an AMPK activitor, has been found to have potential effect in the treatment of diabete and obesity. IC50: 4.3 uM(EC50).
ZLN024 is a novel AMPK allosteric activator and activates α1β1γ1 and α2β1γ1 by around 2–2.5 fold. It activated AMPK in L6 myotubes and stimulated glucose uptake...
HTH-01-015 is a potent and selective inhibitor of NUAK1 with IC50 of 100 nM, does not significantly inhibit NUAK2 (IC50 of >10 μM).
Imeglimin is the first in a new tetrahydrotriazine-containing class of oral antidiabetic agents, the glimins. It has been shown to act on the liver, muscle and ...