|Description||Agomelatine is a melatoninergic agonist and selective antagonist of 5-HT2C receptors, and has been shown to be active in several animal models of depression. Agomelatine (S20098) displayed pKi values of 6.4 and 6.2 at native (porcine) and cloned, human (h)5-hydroxytryptamine (5-HT)2C receptors, respectively.|
|Synonyms||trade names: Valdoxan, Melitor, Thymanax.|
Iloperidone displays high affinity (Ki < 10 nM) for norepinephrine alpha(1)-adrenoceptors, dopamine D(3) and serotonin 5-HT(2A) receptors.
Ondansetron Hydrochloride Dihydrate
Ondansetron hydrochloride dihydrate is a specific and competitive antagonist of serotonin 5-HT3 receptor (Ki = 0.77 nM) with anxiolytic and neuroleptic activiti...
Naluzotan is a selective 5-HT1A receptor partial agonist under the development of EPIX Pharmaceuticals. It is a serotonergic drug for the treatment of generaliz...
The hydrochloride salt form of CP-809101 which is a selective 5-HT2C receptor agonist which probably shows antipsychotic activity and restrains amphetamine-stim...
Eltoprazine belongs the phenylpiperazine class which is a serenic or antiaggressive agent. It acts as an agonist at the 5-HT1A and 5-HT1B receptors and as an an...
Way 100135 is a selective 5-HT1A receptor antagonist originated by Wyeth with IC50 value of 15 nM. IC 50 values for 5-HT1B, 1C, 2,α1, α2 and D2 receptors are ov...
Ansofaxine hydrochloride is a triple reuptake inhibitor of serotonin (IC50= 723 nM), dopamine (IC50= 491 nM) and norepinephrine reuptake (IC50= 763 nM).
Vilazodone (EMD 68843; SB 659746A) is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evalu...
LY 344864 is a brain penetrant, full agonist that specifically targets 5-HT1F receptor (pKi = 8.2) with > 80-fold selectivity over other serotonin receptors (Ki...
Agomelatine is a melatoninergic agonist and selective antagonist of 5-HT2C receptors, and has been shown to be active in several animal models of depression. Ag...
Quetiapine Fumarate is an atypical antipsychotic used in the treatment of schizophrenia, bipolar I mania, bipolar II depression, bipolar I depression.
Tianeptine is a selective facilitator of 5-HT uptake in vitro and in vivo with psychostimulant, anti-ulcer and anti-emetic properties.
BMS-180048, also know as Avitriptan Fumarate, has been found to be a5HT-1B/1D-receptor agonist that was once studied as an anti-migraine agent.
The hydrobromide salt form of NAN-190 which is an effective antagonist of 5-HT1A serotonin receptor.
The hydrochloride salt form of Alosetron, a 5HT3-receptor antagonist, could be used against bowel syndrome.
Piboserod is a highly and potent selective 5-HT4 receptor antagonist which as been studied in vitro as well as in vivo as a pharmacological tool to evaluate the...
Zolmitriptan is a selective serotonin receptor agonist.
Tandospironeis a potent and selective 5-HT1A receptor partial agonist with Ki of 27 nM. It significantly reduces haloperidol-induced bradykinesia in a dose depe...
Setiptiline maleate is a serotonin receptor antagonist. It is used as a tetracyclic antidepressant (TeCA) and acts as a noradrenergic and specific serotonergic ...
Tianeptine sodium is a selective serotonin reuptake enhancer (SSRE), used for treating major depressive episodes.