|Description||RX-195183 is an RARα agonist (Kd=3 nM) with potential antineoplastic activity, modulating the transcription of genes responsible for cell differentiation and proliferation.|
|Solubility||Soluble in DMSO|
|Storage||Store at 2-8 °C|
|Quality Standard||Enterprise Standard|
|Shelf Life||As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly|
TTNPB potently and selectively activates retinoic acid receptors (EC50s = 21, 4, and 2.4 nM for RARα, RARβ, and RARγ, respectively). And it does not act on reti...
Fluorobexarotene is a RXR agonist (Ki = 12 nM; EC50 = 43 nM at RXRα receptors).
Adapalene is more active than indomethacin, betamethasone valerate, tretinoin, isotretinoin or etretinate in inhibiting lipoxygease activity, but it has little ...
UAB30 is a low-toxicity retinoid X receptor-selective agonist selective for the binding and activation of RXR’s over RAR' s. UAB30 is highly effective in the pr...
PA 452 is a RXR antagonist. It can attenuate cell proliferation and induce apoptosis in MCF-7 breast cancer cells.
A high affinity pan-RAR antagonist (AGN194310, K(d) for binding to RARs = 2-5 nM) inhibited colony formation (by 50%) by all three lines at 16-34 nM, and led to...
HX-603 is a RXR agonist.
BMS 493 is a pan-retinoic acid receptor (pan-RAR) inverse agonist that enhances interaction of nuclear corepressor (NCoR) and RARs.
UVI 3003 is a selective and high affinity RXR antagonist. UVI 3003 does not affect the corepressor interaction capacity of the RARα subunit within the context o...
HX 531 is a potent RXR antagonist (IC50 = 18 nM) that inhibits 9-cis retinoic acid-induced transactivation of RXR. HX 531 promotes the differentiation of white ...
ER 50891 is an RARα receptor antagonist (IC50 = 31.2 nM).
CD 3254 is a selective RXRα agonist with no activity at RARα, RARβ or RARγ receptors.
AGN 193109 has been found to be a pan-retinoic acid receptor (RAR) antagonist.
Tazarotene could propel either early or late portions of the period leading to differentiation and G0 arrest and is interchangeable with an RARalpha-selective l...
CD1530 is a potent and selective retinoic acid receptor(RAR) agonist with Ki values of 150, 1500 and 2750 nM for RARγ, RARβ and RARα receptors respectively. It ...
CD 2314 is a potent and selective RARβ receptor agonist (Kd = 145 and >3760 nM for RARβ and RARα receptors, respectively).
Fenretinide is an orally-active synthetic phenylretinamide analogue of retinol (vitamin A) with potential antineoplastic and chemopreventive activities. Fenreti...
Palovarotene is a selective retinoic acid receptor gamma(RAR-γ) agonist for the treatment of emphysema. In small animal studies, palovarotene was claimed to rev...
BMS 270394 is a nuclear retinoic acid receptor (RAR-γ) agonist.
NRX-204647 is a Retinoic acid receptor gamma-selective inverse agonist.