AGN 192403 hydrochloride - CAS 1021868-90-5
Category: Inhibitor
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Molecular Formula:
Molecular Weight:
Imidazoline Receptor
The hydrochloride salt form of AGN 192403, which has been found to show high affinity to imidazoline I1 receptor.
≥95% by HPLC
White Solid
(±)-2-endo-Amino-3-exo-isopropylbicyclo[2.2.1]heptane hydrochloride
Canonical SMILES:
1.Pharmacological characterization of the inhibition by moxonidine and agmatine on the cardioaccelerator sympathetic outflow in pithed rats.
Cobos-Puc LE;Villalón CM;Ramírez-Rosas MB;Sánchez-López A;Lozano-Cuenca J;Gómez-Díaz B;MaassenVanDenBrink A;Centurión D Eur J Pharmacol. 2009 Aug 15;616(1-3):175-82. doi: 10.1016/j.ejphar.2009.06.003. Epub 2009 Jun 13.
This study analysed the inhibition produced by the agonists moxonidine (imidazoline I(1) receptors>alpha(2)-adrenoceptors) and agmatine (endogenous ligand of imidazoline I(1)/I(2) receptors), using B-HT 933 (6-ethyl-5,6,7,8-tetrahydro-4H-oxazolo[4,5-d]azepin-2-amine dihydrochloride; alpha(2)-adrenoceptors) for comparison, on the rat cardioaccelerator sympathetic outflow. Male Wistar rats were pithed and prepared to stimulate the cardiac sympathetic outflow or to receive i.v. bolus of exogenous noradrenaline. Sympathetic stimulation or noradrenaline produced, respectively, frequency-dependent and dose-dependent tachycardic responses. I.v. continuous infusions of moxonidine (3 and 10 microg/kg min), agmatine (1000 and 3000 microg/kg min) and B-HT 933 (30 and 100 microg/kg min) inhibited the tachycardic responses to sympathetic stimulation, but not those to noradrenaline. The cardiac sympatho-inhibition by either moxonidine (3 microg/kg min) or B-HT 933 (30 microg/kg min) was not modified by i.v. injections of saline or the antagonists AGN192403 [(+/-)-2-endo-Amino-3-exo-isopropylbicyclo[2.2.1]heptane hydrochloride; 3000microg/kg; imidazoline I(1) receptors] or BU224 (2-(4,5-dihydroimidazol-2-yl)quinoline hydrochloride; 300 microg/kg; imidazoline I(2) receptors) and abolished by rauwolscine (300 microg/kg; alpha(2)-adrenoceptors).
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CAS 1021868-90-5 AGN 192403 hydrochloride

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